Lionel Tan
A5046443494- Streptococcal Infections and Treatments
- Bacterial Infections and Vaccines
- Malaria Research and Control
- Antimicrobial Resistance in Staphylococcus
- Neonatal and Maternal Infections
- Pneumonia and Respiratory Infections
- Sepsis Diagnosis and Treatment
- Immune Response and Inflammation
- Infective Endocarditis Diagnosis and Management
- Hepatitis B Virus Studies
- Complement system in diseases
- HIV/AIDS drug development and treatment
- Antibiotics Pharmacokinetics and Efficacy
- Amoebic Infections and Treatments
- Antibiotic Use and Resistance
- Hepatitis C virus research
- Antibiotic Resistance in Bacteria
- Mosquito-borne diseases and control
- Pharmaceutical studies and practices
- S100 Proteins and Annexins
- Hemoglobinopathies and Related Disorders
- HIV Research and Treatment
- Primary Care and Health Outcomes
- Pneumocystis jirovecii pneumonia detection and treatment
- Urinary Tract Infections Management
Age UK
2021-2025
ViiV Healthcare (United Kingdom)
2024-2025
GlaxoSmithKline (United Kingdom)
2020-2024
West Middlesex University Hospital
2021-2022
Imperial College London
2010-2021
Royal Brisbane and Women's Hospital
2019
Hammersmith Hospital
2014
Imperial College Healthcare NHS Trust
2012
Charing Cross Hospital
2009
Chelsea and Westminster Hospital
2007-2009
<b><i>Background:</i></b> We tested a new, investigational robotic-assisted bronchoscope system with remotely controlled catheter to access small peripheral bronchi real-time driving under live visualization and distal tip articulation of the catheter. The unique remains stationary once located at biopsy position. <b><i>Objectives:</i></b> primary objectives this study were evaluate safety feasibility new shape-sensing robotic bronchoscopically...
<h2>Abstract</h2><h3>Objectives</h3> To assess the mortality attributable to infections caused by carbapenem-resistant Enterobacterales (CRE) and investigate effect of clinical management on differences in observed outcomes a multinational matched cohort study. <h3>Methods</h3> A prospective matched-cohorts study (NCT02709408) was performed 50 European hospitals from March 2016 November 2018. The main outcome 30-day with an active post-discharge follow-up when applied. CRE included patients...
OBJECTIVES: The host response plays a central role in the pathophysiology of sepsis and severe injuries. So far, no study has comprehensively described overtime changes injury-induced immune profile large cohort critically ill patients with different etiologies. DESIGN: Prospective observational study. SETTING: Adult ICU University Hospital Lyon, France. PATIENTS: Three hundred fifty-three septic, trauma, surgical 175 healthy volunteers were included REAnimation Low Immune Status Marker...
Tafenoquine, co-administered with chloroquine, is approved for the radical cure (prevention of relapse) Plasmodium vivax malaria. In areas chloroquine resistance, artemisinin-based combination therapies are used to treat This study aimed evaluate tafenoquine plus therapy dihydroartemisinin-piperaquine P malaria.In this double-blind, double-dummy, parallel group study, glucose-6-phosphate dehydrogenase-normal Indonesian soldiers microscopically confirmed malaria were randomly assigned by...
ABSTRACT Neisseria meningitidis remains a leading cause of bacterial sepsis and meningitis. Complement is key component natural immunity against this important human pathogen, which has evolved multiple mechanisms to evade complement-mediated lysis. One approach adopted by the meningococcus recruit negative regulator complement system, factor H (fH), its surface via lipoprotein, binding protein (fHbp). Additionally, fHbp antigen in vaccines currently being evaluated clinical trials. Here we...
Neisseria meningitis remains a leading cause of sepsis and meningitis, vaccines are required to prevent infections by this important human pathogen. Factor H binding protein (fHbp) is key antigen that elicits protective immunity against the meningococcus recruits host complement regulator, fH. As high affinity interaction between fHbp fH could impair immune responses, we sought identify non-functional fHbps act as effective immunogens. This was achieved alanine substitution from all three...
Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection. The immune system plays key role in sepsis onset and remains over time heterogeneous manner. Here, we decipher the heterogeneity of first week evolution monocyte HLA-DR (mHLA-DR) surface protein expression septic patients, molecule for adaptive immunity onset. We found verified four distinctive trajectories endotypes discovery (n = 276) verification cohort 102). highlight that 59% patients...
Although multiple individual immune parameters have been demonstrated to predict the occurrence of secondary infection after critical illness, significant questions remain with regards selection, timing and clinical utility such monitoring tests.As a sub-study REALISM study, REALIST score was developed as pragmatic approach help clinicians better identify stratify patients at high risk for infection, using simple set relatively available technically robust biomarkers.This is single-centre...
Neisseria meningitidis is a leading cause of sepsis and meningitis. The bacterium recruits factor H (fH), negative regulator the complement system, to its surface via fH binding protein (fHbp), providing mechanism avoid complement-mediated killing. fHbp an important antigen that elicits protective immunity against meningococcus has been divided into three different variant groups, V1, V2 V3, or families A B. However, immunisation with V1 does not result in cross-protection V3 vice versa....
We analysed blood DNAemia of TTV and four herpesviruses (CMV, EBV, HHV6, HSV-1) in the REAnimation Low Immune Status Marker (REALISM) cohort critically ill patients who had presented with either sepsis, burns, severe trauma, or major surgery. The aim was to identify common features related virus injury-associated pathologies specific linking one several viruses a particular pathological context.Overall individual viral were measured over month using quantitative PCR assays from 377 REALISM...
Background: Dolutegravir/Lamivudine is recommended for initial antiretroviral therapy (ART) in adults living with HIV-1; however, no clinical trials have assessed this regimen adolescents, a potentially more challenging population to treat. We evaluated efficacy, safety, and pharmacokinetics of dolutegravir/lamivudine as ART adolescents HIV-1. Setting: Nine centers Thailand, Kenya, South Africa. Methods: In the single-arm, open-label, phase 3b DANCE study (NCT03682848), naive aged ≥12 <18...
Intensive care unit (ICU) patients develop an altered host immune response after severe injuries. This may evolve towards a state of persistent immunosuppression that is associated with adverse clinical outcomes. The expression human leukocyte antigen DR on circulating monocytes (mHLA-DR) and ex vivo release tumor necrosis factor α (TNF-α) by lipopolysaccharide-stimulated whole blood are two related biomarkers offered to characterize this phenomenon. purpose study was concomitantly evaluate...
Carbapenem-resistant Enterobacterales (CRE) bloodstream infections (BSIs) are a major threat to patients. To date, data on risk factors have been limited, with low internal and external validity. In this multicentre study, for CRE BSI were determined by comparison two control groups: patients carbapenem-susceptible (CSE) BSI, without infection (uninfected patients).
Summary. Reports have described a decrease in glomerular filtration rate (eGFR) associated with tenofovir disoproxil fumarate (TDF) use HIV positive individuals. However, no study has examined renal function over prolonged period HIV/hepatitis B virus (HBV) co‐infected patients. We assessed the long‐term durability and toxicity of TDF cohort 39 e antigen (eAg) patients commenced on 245 mg daily either addition to or as part standard antiretroviral therapy. Immunological virological...