A5050079005- Lymphoma Diagnosis and Treatment
- Mosquito-borne diseases and control
- Chronic Lymphocytic Leukemia Research
- Viral Infections and Vectors
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- SARS-CoV-2 and COVID-19 Research
- CAR-T cell therapy research
- COVID-19 and healthcare impacts
- Immune Cell Function and Interaction
- Zoonotic diseases and public health
- Chronic Myeloid Leukemia Treatments
- Viral-associated cancers and disorders
- CNS Lymphoma Diagnosis and Treatment
- Erythrocyte Function and Pathophysiology
- Malaria Research and Control
- Cardiac tumors and thrombi
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Virology and Viral Diseases
- Parvovirus B19 Infection Studies
- Blood groups and transfusion
- Inflammatory Biomarkers in Disease Prognosis
- Autoimmune and Inflammatory Disorders Research
- COVID-19 Impact on Reproduction
- Acute Myeloid Leukemia Research
Cliniques Universitaires Saint-Luc
2018-2025
Boehringer Ingelheim (Egypt)
2024
University of Ghana
2023
UCLouvain
2020-2023
Université Paris Cité
2023
Institut Pasteur
2023
Institut Pasteur de la Guyane
2019-2022
de Duve Institute
2022
Ludwig Cancer Research
2022
Research Institute Hospital 12 de Octubre
2021
JAK2 constitutive activation/overexpression is common in classical Hodgkin lymphoma, and several cytokines stimulate lymphoma cells by recognizing JAK1-/JAK2-bound receptors. JAK blockade may thus be therapeutically beneficial lymphoma. In this phase II study we assessed the safety efficacy of ruxolitinib, an oral JAK1/2 inhibitor, patients with relapsed/refractory The primary objective was overall response rate according to International Harmonization Project 2007 criteria. Thirty-three...
Characterizing the circulation of Mayaro virus (MAYV), an emerging arbovirus threat, is essential for risk assessment but challenging due to cross-reactivity with other alphaviruses such as chikungunya (CHIKV). Here, we develop analytical framework jointly assess MAYV epidemiology and extent CHIKV from serological data collected throughout French Guiana (N = 2697). We find strong evidence important sylvatic cycle most infections occurring near natural reservoir in rural areas individuals...
Abstract Primary mediastinal B-cell lymphoma (PMBL) is a rare type of aggressive typically affecting young female patients. The first-line standard care remains debated. We performed large multicenter retrospective study in 25 centers France and Belgium to describe PMBL patient outcomes after treatment real-life settings. A total 313 patients were enrolled received rituximab (R) plus ACVBP (doxorubicin, cyclophosphamide, vindesine, bleomycin, prednisone) (n = 180) or CHOP (cyclophosphamide,...
Abstract Background Since the identification of Zika virus (ZIKV) in Brazil May 2015, has spread throughout Americas. However, ZIKV burden general population affected countries remains unknown. Methods We conducted a survey different communities French Guiana through individual interviews and serologic during June–October 2017. All serum samples were tested for anti-ZIKV immunoglobulin G antibodies using recombinant antigen-based SGERPAxMap microsphere immunoassay, some them further...
Despite the health, social and economic impact of arboviruses in French Guiana, very little is known about extent to which infection burden shared between individuals. We conducted a large multiplexed serological survey among 2697 individuals from June October 2017. All serum samples were tested for IgG antibodies against DENV, CHIKV, ZIKV MAYV using recombinant antigen-based microsphere immunoassay with subset further evaluated through anti-ZIKV microneutralization tests. The overall DENV...
This phase 1b/2 PCYC-1123-CA study evaluated efficacy and safety of the combination ibrutinib, lenalidomide, rituximab (iR2 regimen) in patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL) ineligible for stem cell transplantation.In 2, non-germinal centre B-cell-like DLBCL received oral ibrutinib 560 mg once daily lenalidomide 20 or 25 on Days 1-21 each 28-day cycle until disease progression unacceptable toxicity intravenous 375 mg/m2 Day 1 Cycles 1-6. The primary endpoint...
While Latin America has been heavily affected by the pandemic, only a few seroprevalence studies have conducted there during first epidemic wave in half of 2020.A cross-sectional survey was performed between 15 July 2020 and 23 among individuals who visited 4 medical laboratories or 5 health centers for routine screening clinical management, with exception symptomatic suggestive cases covid-19. Samples were screened presence anti-SARS-CoV-2 IgG directed against domain S1 SARS-CoV-2 spike...
Q fever is a zoonosis caused by Coxiella burnetii which among the major agents of community-acquired pneumonia in French Guiana. Despite its relatively high incidence, epidemiology Guiana remains unclear, and all previous studies have considered transmission from livestock unlikely, suggesting that wild reservoir responsible for transmission. A country-wide seroprevalence survey 2697 participants was conducted. Serum samples were tested phase II IgG antibodies ELISA indirect...
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disease, which can be primary (due to genetic mutation) or secondary malignancy, infection and rheumatologic diseases. Data concerning Belgian patients with adult HLH are lacking.This retrospective study was performed in teaching hospital Belgium. All cases of HLH, from December 2010 April 2022, were reviewed. Patients more than five HLH-2004 criteria and/or HScore >80% included the study. The objective our describe clinical...
Background French Guiana, a overseas department located in South America between Brazil and Surinam, is the only European territory geographically Amazonian forest complex considered endemic for yellow fever (YF). In context of emergent threat YF Latin America, we conducted large household cross-sectional survey from June to October 2017 estimate vaccination coverage population determine associations with sociodemographic geographical characteristics. Methodology/Principal findings total,...
The LyKID study is a nationwide survey in France of lymphoma patients with renal involvement based on biopsy and/or imaging, to evaluate its impact disease outcome and function. A total 87 adult cases B or T-cell lymphomas were retrospectively analyzed. Interstitial topography was observed most the kidney biopsies (54/66; 80%). Kidney failure (glomerular filtration rate <60 mL/min/1.73 m2) present 47% associated non-significantly different outcome. After treatment, 44% had persistent chronic...
Abstract Background SARS-CoV-2 seroprevalence studies are crucial for clarifying dynamics in affected countries and determining the route that has already been achieved towards herd immunity. While Latin America heavily by pandemic, only a few have conducted there. Methods A cross-sectional survey was performed between 15 July 2020 23 4 medical biology laboratories 5 health centers of French Guiana, representing period shortly after epidemic peak. Samples were screened presence...
Abstract A 62-y-old man developed Covid-19 infection. Fourteen days after the first respiratory symptoms, he presented biological signs of hemolysis with cold agglutinins 1/16384. Other causes auto-immune hemolytic anemia (infectious, hematological,…) were excluded.
Objective Taenia solium (Ts) cysticercosis is a neglected zoonotic disease particularly prevalent in Madagascar. Few data are available for children, current mainly rely on antibody prevalence. We sought to determine the Ts-antigen seroprevalence–determining active cysticercosis—amongst school children from various cities Madagascar (excluding capital) and evaluated associated risk factors. Methods In seven Madagascar, presence of (n = 1751) was investigated 2007 using B158/B60 antigen...