A5052359098- Lymphoma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Chronic Lymphocytic Leukemia Research
- Atmospheric and Environmental Gas Dynamics
- Lipid Membrane Structure and Behavior
- Healthcare Systems and Practices
- Recycling and Waste Management Techniques
- Coenzyme Q10 studies and effects
- Spectroscopy Techniques in Biomedical and Chemical Research
- Atmospheric chemistry and aerosols
- Health, Medicine and Society
- Cancer Treatment and Pharmacology
- ATP Synthase and ATPases Research
- Spectroscopy and Quantum Chemical Studies
- Cancer therapeutics and mechanisms
- Airway Management and Intubation Techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- Acute Lymphoblastic Leukemia research
- Municipal Solid Waste Management
- Thyroid and Parathyroid Surgery
- Advanced battery technologies research
- Cholesterol and Lipid Metabolism
- COVID-19 and healthcare impacts
- Lipoproteins and Cardiovascular Health
Centre Hospitalier de la Côte Basque
2023-2025
Université Paris Cité
2010-2024
Hôpital Saint-Louis
2012-2024
Assistance Publique – Hôpitaux de Paris
2015-2024
Polytechnique Montréal
2024
Inserm
2024
Hôpital Robert-Debré
2016-2022
Délégation Paris 7
1996-2022
Institut d’Hématologie et d’Oncologie Pédiatrique
2019
Palmetto Hematology Oncology
2019
Abstract Chimeric antigen receptor (CAR) T-cell therapy has emerged as an option for relapsed/refractory aggressive B-cell lymphomas that have failed 2 lines of therapy. Failures usually occur early after infusion. The purpose our study was to identify factors may predict failure, particularly progression (EP), within the first month Characteristics 116 patients were analyzed at time decision (TD) use commercial CAR (axicabtagene ciloleucel, n = 49; tisagenlecleucel 67) and treatment (TT),...
Glycogen synthase kinase 3β (GSK3β) inhibitors, especially the mood stabilizer lithium chloride, are also used as neuroprotective or anti-inflammatory agents. We studied influence of LiCl on remyelination peripheral nerves. showed that treatment adult mice with after facial nerve crush injury stimulated expression myelin genes, restored structure, and accelerated recovery whisker movements. promoted sciatic crush. demonstrated gene MPZ PMP22 promoter activities, transcripts, protein levels...
Cytoskeleton modifications are required for neuronal stem cells to acquire polarization. Little is known, however, about mechanisms that orchestrate cytoskeleton remodeling along neuritogenesis. Here, we show the silencing of cellular prion protein (PrPC) impairs initial sprouting neurites upon induction differentiation 1C11 neuroectodermal cell line, indicating PrPC necessary Such function relies on its capacity negatively regulate clustering, activation, and signaling activity β1 integrins...
BackgroundPatients with lymphoma are immunocompromised because of the disease per se and its treatments. We aimed to describe characteristics patients hospitalized for Coronavirus Disease 2019 (Covid-19) analyze pre-Covid-19 determinants mortality.MethodsThis retrospective multicentric cohort study used Programme de Médicalisation des Systèmes d'Information database identify all adult lymphoma, Covid-19 in March April 2020, 12 hospitals three French regions pandemic outbreaks. The were...
Methane is one of the important greenhouse gases accumulating in atmosphere today. The increased loading over past 2 centuries thought to be result anthropogenic emissions. Here we present records δ 13 C CH 4 firn air from South Pole and trapped bubbles a short ice core Siple Dome, Antarctica, that help constrain historical emissions various sources throughout last centuries. Using two samplings 1995 2001 calculate has by an average 0.06 ± 0.02‰/yr 6 years between samplings. Our results...
In several neurodegenerative diseases of the CNS, oligodendrocytes are implicated in an inflammatory process associated with altered levels oxysterols and enzymes such as secreted phospholipase A2 (sPLA2). view scarce literature related to this topic, we investigated oxysterol effects on these myelinating glial cells. Natural 25-hydroxycholesterol (25-OH; 1 10 microM) oligodendrocyte cell line (158N) morphology triggered apoptosis (75% after 72 h). These were mimicked by 22(S)-OH (1 which...
Abstract Primary mediastinal B-cell lymphoma (PMBL) is a rare type of aggressive typically affecting young female patients. The first-line standard care remains debated. We performed large multicenter retrospective study in 25 centers France and Belgium to describe PMBL patient outcomes after treatment real-life settings. A total 313 patients were enrolled received rituximab (R) plus ACVBP (doxorubicin, cyclophosphamide, vindesine, bleomycin, prednisone) (n = 180) or CHOP (cyclophosphamide,...
Tafasitamab combined with lenalidomide was approved in Europe 2021 for transplant-ineligible patients relapsed/refractory diffuse large B-cell lymphoma. Approval based on the L-MIND study, which demonstrated a 57.5% overall response rate (ORR), 41.3% complete (CR) rate, 12.1 months median progression-free survival (PFS), and 33.5 (OS) at five years. The multicenter retrospective EarlyMIND study analyzed real-world efficacy treatment patterns of receiving tafasitamab plus second (2L cohort)...
Abstract. A historical record of changes in the N2O isotope composition is important for a better understanding global atmospheric budget. Here we have combined measurements trapped gases firn and ice cores one Arctic site (North GReenland Ice core Project - NGRIP) Antarctic (Berkner Island). We performed 18O position dependent 15N isotopic N2O. By comparing these data to simulations carried out with air diffusion model, reconstructed temporal evolution signatures since pre-industrial times....
The pro-apoptotic effector Bid induces mitochondrial apoptosis in synergy with Bax and Bak. In response to death receptors activation, is cleaved by caspase-8 into its active form, tBid (truncated Bid), which then translocates the mitochondria trigger cytochrome c release subsequent apoptosis. Accumulating evidence now indicate that binding of initiates an ordered sequences events prime from action Bak: (1) interacts via a specific cardiolipin (CL) immediately disturbs structure function...
Abstract. N2O is currently the third most important anthropogenic greenhouse gas in terms of radiative forcing and its atmospheric mole fraction rising steadily. To quantify growth rate causes over past decades, we performed a multi-site reconstruction isotopic composition using new previously published firn air data collected from Greenland Antarctica combination with diffusion densification model. The showed that while global mean increased (290 ± 1) nmol mol−1 1940 to (322 2008, decreased...
Abstract. Trends of carbon monoxide (CO) for the past 100 years are reported as derived from Antarctic firn drilling expeditions. Only one 3 campaigns provided high quality results. The trend was reconstructed using a air model in forward mode to constrain age distributions and assuming CO increase be proportional its major source, namely CH4. results suggest that has increased by ~38%, 38±7 52.5±1.5 ppbv over period roughly years. concentrations on volumetric scale which corresponds ~1.08...
BH3 interacting domain death agonist (Bid), a pro-apoptotic member of the Bcl-2 family proteins, is activated through cleavage by caspase-8. The active C-terminal fragment Bid (tBid) translocates to mitochondria where it interacts with cardiolipins at contact sites and induces release cytochrome c mechanism that not yet fully understood. It has been shown alpha-helices alphaH6 alphaH7 (which create hairpin-forming tBid) mediate insertion into mitochondrial membranes are essential for...
Ibrutinib treatment has been shown to increase survival in patients with B cell malignancies. Real-life data suggest a large part of discontinuations are due toxicities, impairing ibrutinib efficacy. We aimed assess the impact pharmaceutical care program on efficacy and safety ibrutinib. This single-center, cohort, observational study enrolled Patients were either assigned or receive usual care, based physician decision. The was conducted by clinical pharmacists specializing oncology...