Javier Alejandro Sfalcin
A5063318211- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- HIV-related health complications and treatments
- Breastfeeding Practices and Influences
- Hepatitis B Virus Studies
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
Research Centre in Biological Chemistry of Córdoba
2024-2025
•An international cohort of 3,355 patients with hepatitis C from 22 countries was evaluated for drug resistance following DAA therapy.•Nearly all harbored drug-resistant variants after treatment failure, over 2/3 having against ≥2 classes.•Pathways to included enrichment highly resistant and selection multiple variants.•Previously unrecognized in who failed NS5A inhibitors were identified at high frequencies.•Resistance frequent older people cirrhosis those infected genotypes 1b 4 failure....
Hepatitis C virus (HCV) consists of 7 genotypes and multiple subtypes. With the introduction pangenotypic direct-acting antivirals (DAAs), utility genotype as a prognostic factor for treatment tends to be less relevant. However, it is useful those patients who require second DAAs regimen. In Argentina, there are few reports on prevalence HCV genotypes, which indicate varied changing distribution in different cities. This study aimed determine frequency cities Argentina last ten years....