A5034324107- Antibiotic Resistance in Bacteria
- COVID-19 Clinical Research Studies
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Use and Resistance
- Pneumonia and Respiratory Infections
- Infective Endocarditis Diagnosis and Management
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and healthcare impacts
- Orthopedic Infections and Treatments
- Sepsis Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Helicobacter pylori-related gastroenterology studies
- Clostridium difficile and Clostridium perfringens research
- Poxvirus research and outbreaks
- Antifungal resistance and susceptibility
- Hepatitis C virus research
- Nosocomial Infections in ICU
- Veterinary medicine and infectious diseases
- Polyomavirus and related diseases
- Gut microbiota and health
- Immune Cell Function and Interaction
- Essential Oils and Antimicrobial Activity
- Bacterial biofilms and quorum sensing
Sapienza University of Rome
2016-2025
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani
2012-2025
Hospital Universitari Germans Trias i Pujol
2025
Policlinico Umberto I
2015-2025
University of Bologna
2023
Azienda Ospedaliero Universitaria Ospedali Riuniti
2023
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2022
Istituto Neurologico Mediterraneo
2019-2021
Ministero degli Affari Esteri
2019
Istituto Pasteur
2016
Abstract Background A growing body of observational evidence supports the value ceftazidime-avibactam (CAZ-AVI) in managing infections caused by carbapenem-resistant Enterobacteriaceae. Methods We retrospectively analyzed data on use and outcomes CAZ-AVI therapy for Klebsiella pneumoniae carbapenemase–producing K. (KPC-Kp) strains. Multivariate regression analysis was used to identify variables independently associated with 30-day mortality. Results were adjusted propensity score receipt...
Coronavirus 2019 (COVID-19) is a pandemic associated with high risk of mortality. Human serum albumin (HSA) an acute phase reactant antioxidant property; however, its behavior and impact on survival in COVID-19 patients have never been studied so far. Among 319 followed up for median 19 days, 64 died. Compared survivors, nonsurvivors had more prevalence intensive care unit (ICU) admission, chronic obstructive pulmonary disease (COPD), heart failure, elevated levels D-dimer, high-sensitivity...
Superinfections in patients hospitalized intensive care unit (ICU) are an important and challenging complication, also COVID-19. However, no definitive data available about the role of multidrug-resistant Acinetobacter baumannii (MDR-AB) COVID-19.This was a single-center, cross-sectional study including with MDR-AB infections admitted to ICU or without COVID-19, between January 2019 2021. The primary objective evaluate risk factor for COVID-19 other etiology. secondary endpoints were 30-days...
Macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES (regulated on activation, normal T cell expressed secreted), which are the natural ligands of CC-chemokine receptor CCR5, inhibit replication MT-2- negative strains HIV-1 by interfering with ability these to utilize CCR5 as a coreceptor for entry in CD4(+) cells. The present study investigates capacity killer (NK) cells isolated from HIV-infected individuals produce CC-chemokines suppress HIV autologous, endogenously...
Nox2 is responsible for artery dysfunction via production of reactive oxidant species. RNA viruses may activate Nox2, but it unknown if this occurs in coronavirus 2019(Covid-19). activation by soluble Nox2-derived peptide(sNox2-dp) was measured patients hospitalized Covid-19 (n = 182) and controls 91). sNox2-dp values were higher versus severe non Covid-19. Patients with thrombotic events(n 35,19%) had than event-free ones. A logistic regression analysis showed that sNox2 coronary heart...
ABSTRACT Increasing antimicrobial resistance reduces treatment options for implant-associated infections caused by methicillin-resistant Staphylococcus aureus (MRSA). We evaluated the activity of fosfomycin alone and in combination with vancomycin, daptomycin, rifampin, tigecycline against MRSA (ATCC 43300) a foreign-body (implantable cage) infection model. The MICs individual agents were as follows: fosfomycin, 1 μg/ml; 0.125 0.04 tigecycline, μg/ml. Microcalorimetry showed synergistic...
Background: Experience in real clinical practice with ceftazidime-avibactam for the treatment of serious infections due to gram−negative bacteria (GNB) other than carbapenem-resistant Enterobacterales (CRE) is very limited. Methods: We carried out a retrospective multicenter study patients hospitalized 13 Italian hospitals who received ≥72 h GNB CRE assess rates success, resistance development, and occurrence adverse events. Results: Ceftazidime-avibactam was used treat 41 CRE. Median age 62...
Biofilm is the trigger for majority of infections caused by ability microorganisms to adhere tissues and medical devices. Microbial cells embedded in biofilm matrix are highly tolerant antimicrobials escape host immune system. Thus, refractory nature biofilm-related (BRIs) still represents a great challenge physicians serious health threat worldwide. Despite its importance, microbiological diagnosis BRI difficult not routinely assessed clinical microbiology. Moreover, bacteria up 100-1000...
Background: SARS-CoV-2 is associated with an increased risk of venous and arterial thrombosis, but the underlying mechanism still unclear. Methods: We performed a cross-sectional analysis platelet function in 25 10 healthy subjects by measuring Nox2 (NADPH oxidase 2)-derived oxidative stress thromboxane B 2 , investigated if administration monoclonal antibodies against S protein (Spike protein) affects activation. Furthermore, we vitro or plasma from enhanced Results: Ex vivo studies showed...
Little is known on the burden of co-infections and superinfections in a specific setting such as respiratory COVID-19 sub-intensive care unit. This study aims to (i) assess prevalence concurrent unit, (ii) evaluate risk factors for development (iii) impact in-hospital mortality.
The first evidence that Orthopoxvirus induced the expansion in vivo and recall of effector innate Vδ2 T-cells was described a macaque model. Although, an engagement αβ specific response patients infected with human monkeypox (Mpox) demonstrated, little is known about role γδ during Mpox infection. IFN-γ-producing resistance to poxviruses may key inducing protective type 1 memory immunity. We analyzed kinetics T-cell from acute phase up three months after Fourteen MSM subjects (5 PWH, 35.7%)...
Intravenous fosfomycin (FOS) is a broad-spectrum antibiotic primarily used in combination therapy to treat severe infections caused by both Gram-positive (GP) and Gram-negative (GN) pathogens, including multi-drug resistant (MDR) bacteria. The aim of this study, the largest date, was evaluate effectiveness, safety, usage patterns, patient characteristics FOS real-world setting. Interim analysis an ongoing, prospective, non-interventional, multicentre study five European countries, involving...
This study demonstrates that several CC-chemokines, including those inhibit entry and replication of macrophage-tropic strains HIV, increase the T cell (T)-tropic in CD4 + cells. Enhancement T-tropic HIV is observed at early stages replication, requires signaling through inhibitory guanine nucleotide-binding regulatory (G i ) proteins, associated with increased surface colocalization coreceptor CXCR4. These findings may further our understanding factors influence spread vivo suggest use...
This study demonstrates that the β-chemokines macrophage inflammatory proteins 1α and 1β (MIP-1α MIP-1β) and, RANTES (regulated on activation, normally T-cell expressed secreted) inhibit human immunodeficiency virus (HIV) replication in anti-CD3 or recall antigen-stimulated peripheral blood mononuclear cells (PBMCs) of asymptomatic HIV-infected subjects. Significant levels were produced by both CD4 + CD8 PBMC subsets from individuals. Neutralization endogenous MIP-1α, MIP-1β, did not rescue...
Herein, an extended investigation of Tea tree oil (TTO) against a number multi-drug resistant (MDR) microorganisms in liquid and vapor phases is reported.The activity TTO was tested methicillin-sensitive Staphylococcus aureus (MSSA), Escherichia coli, clinical strains methicillin-resistant S. (MRSA), extended-spectrum beta lactamases producer carbapenem-sensitive Klebsiella pneumoniae (ESBL-CS-Kp), carbapenem-resistant K. (CR-Kp), Acinetobacter baumannii (CR-Ab), Pseudomonas aeruginosa...
ABSTRACT Enterococcal implant-associated infections are difficult to treat because antibiotics generally lack activity against enterococcal biofilms. We investigated fosfomycin, rifampin, and their combinations planktonic adherent Enterococcus faecalis (ATCC 19433) in vitro a foreign-body infection model. The MIC/MBC log values were 32/>512 μg/ml for 4/>64 1/2 ampicillin, 2/>256 linezolid, 16/32 gentamicin, 1/>64 vancomycin, 1/5 daptomycin. In time-kill studies, fosfomycin was...
Abstract Background Few data are reported in the literature about outcome of patients with severe extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) infections treated ceftolozane/tazobactam (C/T), empiric or definitive therapy. Methods A multicenter retrospective study was performed Italy (June 2016–June 2019). Successful clinical defined as complete resolution signs/symptoms related to ESBL-E infection and lack microbiological evidence infection. The primary end point...