A5001363784- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Renal Diseases and Glomerulopathies
- Autoimmune and Inflammatory Disorders Research
- Kawasaki Disease and Coronary Complications
- Adolescent and Pediatric Healthcare
- Inflammatory Myopathies and Dermatomyositis
- Pharmacological Effects and Toxicity Studies
- Oral Health Pathology and Treatment
- Inflammasome and immune disorders
- Mechanical Circulatory Support Devices
- COVID-19 Clinical Research Studies
- Bone fractures and treatments
- COVID-19 Impact on Reproduction
- Metabolism and Genetic Disorders
- Atherosclerosis and Cardiovascular Diseases
- Immunodeficiency and Autoimmune Disorders
- Infectious Diseases and Tuberculosis
- Complement system in diseases
- Monoclonal and Polyclonal Antibodies Research
- Trauma Management and Diagnosis
- Systemic Sclerosis and Related Diseases
- Eosinophilic Disorders and Syndromes
- Hip and Femur Fractures
- Dermatological and Skeletal Disorders
Stanley Medical College
2022-2025
University of Wisconsin–Madison
2025
Saveetha University
2022-2025
Texas A&M University
2024
Vinayaka Missions Medical College and Hospitals
2024
Christian Medical College, Vellore
2015-2024
London School of Economics and Political Science
2024
Christian Medical College
2011-2024
Bryan College
2024
Marymount University
2024
UNC93B1 is a transmembrane domain protein mediating the signaling of endosomal Toll-like receptors (TLRs). We report five families harboring rare missense substitutions (I317M, G325C, L330R, R466S, and R525P) in causing systemic lupus erythematosus (SLE) or chilblain (CBL) as either autosomal dominant recessive traits. As for D34A mutation murine lupus, we recorded gain TLR7 and, to lesser extent, TLR8 activity with I317M (in vitro) G325C vitro ex vivo) variants context SLE. Contrastingly,...
Aim To assess outcome of 10 'difficult to treat' patients with Takayasu arteritis (TA) treated tocilizumab. Methods Records TA who received at least six infusions tocilizumab were studied and data related demography, medications, investigations, angiography analyzed. Results Median age, disease duration Indian Arteritis Score (ITAS) 24.5 (13–53) years, 25.5 (1.5–60) months 4.5 (0–13), respectively. All had active ITAS ≥ 1 and/or they angiographically in spite treatment steroids second line...
Objective. To study the clinical profile and outcome of Asian Indian children with childhood-onset Takayasu arteritis (c-TA). Methods. Records were studied patients c-TA onset prior to age 16. Disease Extent Index-Takayasu (DEI.TAK), Arteritis Score 2010, Damage (TADS) calculated retrospectively from electronic records. Cumulative incidence sustained remission was estimated using Kaplan-Meier curve. Results. There 40 c-TA, median 12.5 years (range 1–16) diagnostic delay 11.3 months 1–60)....
Objective Deficiency of adenosine deaminase 2 (DADA2) is a potentially fatal monogenic syndrome characterized by variable manifestations systemic vasculitis, bone marrow failure, and immunodeficiency. Most cases are diagnosed pediatric care providers, given the typical early age disease onset. This study was undertaken to describe clinical phenotypes treatment response both in adults children with DADA2 India. Methods A retrospective analysis adult patients at various rheumatology centers...
The status of vascular lesion treatment using percutaneous intervention (PI) in Takayasu arteritis (TAK) remains unresolved. This study sought to develop PI strategies appropriate for TAK. A prospectively maintained single-center database TAK procedures from 1996 2022 was analyzed retrospectively. Obstructive lesions were treated by elective stenting (using bare or covered stents), balloon angioplasty (BA), cutting-balloon (CBA), with adjunctive suboptimal BA CBA results. PIs repeated...
Arsenic, a contaminant of groundwater and irrigated crops, is global public health hazard. Exposure to low levels arsenic through food extends well beyond the areas with high content in water.
To develop and replicate, using data-driven methods, a novel classification system in Takayasu's arteritis based on distribution of arterial lesions.Patients were included from four international cohorts at major academic centres: India (Christian Medical College Vellore); North America (National Institutes Health, Vasculitis Clinical Research Consortium Cleveland Clinic Foundation). All patients underwent whole-body angiography the aorta branch vessels, with categorization damage (stenosis,...
OBJECTIVES. Our goal was to determine long-term efficacy and safety of B-cell–depletion therapy for children with autoimmune thrombocytopenia hemolytic anemia in pediatric systemic lupus erythematosus. PATIENTS AND METHODS. A retrospective, single-center cohort study conducted including all patients erythematosus who were diagnosed and/or treated rituximab. Treatment parameters monitored recorded. RESULTS. Nine included the study: 5 had thrombocytopenia, 3 anemia, 1 both. There female 4 male...
The urethra is considered a passive conduit for urine. Here, we reveal surprising multicellular signaling pathway guiding the urethra’s dynamic response to an invading pathogen. Using genetic approach in female mice, deposited uropathogenic Escherichia coli into distal establish model of ascending urinary tract infection that progresses bladder within 4 h. We show urethral neuroendocrine cells (UNECs), and serotonin they synthesize, protect from bacterial colonization. tested hypothesis...
Introduction: This study compares and analyses the functional radiological outcome of Halder nailing with plate fixation for humeral shaft fracture. To study, time taken union status in fractures treated intramedullary nail through assessment to by shoulder joint range movements after surgery. Case Report: One hundred two cases fracture received an emergency or outpatient Department Orthopaedics at Government Stanley Medical College Hospital during 3-year period July 2021–June 2024 were...
We report a case of Plasmodium vivax malaria complicated by shock and ARDS. The patient responded to oral chloroquine primaquine PCR was positive for P. DNA negative falciparum DNA. may cause severe complications where the possibility mixed infections exists, blood should be sent analysis so that can reliably excluded.
Objective. To examine the frequency and risk factors for symptomatic avascular necrosis (AVN) in childhood-onset systemic lupus erythematosus (cSLE). Methods. A single-center, nested, matched, case-control design was used. There were 617 patients with cSLE followed at Hospital Sick Children (SickKids) Lupus Clinic between July 1982 June 2013 included study. The AVN cohort consisted of 37 identified clinical findings diagnosis confirmed by 1 or more imaging modalities. Three controls matched...
Neuroimaging has an important role in detecting CNS involvement children with systemic or isolated hemophagocytic lymphohistiocytosis. We characterized a cohort of pediatric patients lymphohistiocytosis focusing on neuroradiologic features and assessed whether distinct MR imaging patterns genotype correlations can be recognized.We retrospectively enrolled consecutive diagnosed treated at 2 neurology centers between 2010 2018. Clinical data were analyzed.Fifty-seven (40 primary, 70%) median...