A5071964320- Wireless Communication Networks Research
- Autoimmune and Inflammatory Disorders Research
- Sarcoma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Advanced Wireless Communication Techniques
- Blood disorders and treatments
- Renal Diseases and Glomerulopathies
- Rheumatoid Arthritis Research and Therapies
- Lymphoma Diagnosis and Treatment
- graph theory and CDMA systems
- Renal and related cancers
- Immune Cell Function and Interaction
- Cardiac tumors and thrombi
- Bone Tumor Diagnosis and Treatments
- Metabolism, Diabetes, and Cancer
- Inflammasome and immune disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- S100 Proteins and Annexins
- Cancer-related Molecular Pathways
- Immunodeficiency and Autoimmune Disorders
- Vascular Tumors and Angiosarcomas
- Inflammation biomarkers and pathways
- NF-κB Signaling Pathways
- Mitochondrial Function and Pathology
Cliniques Universitaires Saint-Luc
2016-2025
de Duve Institute
2021-2025
UCLouvain
2024-2025
Université de Toulouse
2025
Centre Hospitalier Universitaire de Toulouse
2020-2024
Victor (Japan)
2021
Hôpital des Enfants
2010-2021
Queen Fabiola Children's University Hospital
2021
Université Libre de Bruxelles
2021
Centre Hospitalier Universitaire Brugmann
2021
Epstein-Barr virus (EBV) preferentially infects epithelial cells and B lymphocytes sometimes T NK lymphocytes. Persistence of EBV-infected results in severe lymphoproliferative disorders (LPDs). Diagnosis EBV-driven or cell LPD chronic active EBV diseases (CAEBV) is difficult, often requiring biopsies. Herein, we report a flow-FISH cytometry assay that detects expressing EBV-encoded small RNAs (EBERs), allowing rapid identification among PBMCs. B, T, and/or were detectable various...
Abstract Neutropenia and neutrophil dysfunction found in deficiencies G6PC3 the glucose‐6‐phosphate transporter (G6PT/SLC37A4) are due to accumulation of 1,5‐anhydroglucitol‐6‐phosphate (1,5‐AG6P), an inhibitor hexokinase made from 1,5‐anhydroglucitol (1,5‐AG), abundant polyol present blood. Lowering blood 1,5‐AG with SGLT2 greatly improved counts function G6PC3‐deficient mice patients G6PT‐deficiency. We evaluate this treatment two children. While neutropenia was severe one child (PT1),...
IKKα, encoded by CHUK, is crucial in the non-canonical NF-κB pathway and part of IKK complex activating canonical alongside IKKβ. The absence IKKα causes fetal encasement syndrome humans, fatal utero, while an impaired IKKα-NIK interaction was reported a single patient combined immunodeficiency. Here, we describe compound heterozygous variants kinase domain female with hypogammaglobulinemia, recurrent lung infections, Hay–Wells syndrome-like features. We showed that both were...
ABSTRACT Background and aims Head neck germ cell tumors (HN‐GCTs), excluding the central nervous system, are rare frequently contain mature or immature teratoma (MIT) compounds. The of this study were to analyze risk malignant transformation after MIT HN‐GCTs, describe treatments sequelae, propose recommendations for follow up these patients. Methods National multicentric retrospective all patients aged from birth 17 years, treated in France between 2000 2021 a HN‐GCT histotypes. Patients...
To describe the clinical characteristics and outcome of patients with Li-Fraumeni-associated rhabdomyosarcoma (RMS).Retrospective analysis data from 31 French RMS diagnosed before age 20 years associated a TP53 pathogenic germline variant. Cases were identified through Li-Fraumeni database. Central histologic review was performed in 16 cases.The median at diagnosis 2.3 years, follow-up 9.1 (0.3-34.8). The main tumor sites head neck (n = 13), extremities 8), trunk 8). local pathology report...
Introduction In the management of juvenile idiopathic arthritis (JIA), there is a lack diagnostic and prognostic biomarkers. This study assesses use serum calprotectin (sCal) as marker to monitor disease activity, classification prognosis tool response treatment or risk flares in patients with JIA. Methods Eighty-one JIA from CAP48 multicentric cohort were included this study, well 11 non-paediatric healthy controls. An ELISA method was used quantify sCal commercial kit. Results Patients an...
The vast majority of adult cancer cells achieve cellular immortality by activating a telomere maintenance mechanism (TMM). While this is mostly achieved the de-silencing hTERT telomerase gene expression, an alternative homologous recombination-based and telomerase-independent mechanism, known as ALT (Alternative Lengthening Telomeres), frequently activated in subset tumors, including paediatric cancers. Being absent from normal cells, offers interesting perspectives for new targeted...
The cardinal features of Ectrodactyly, Ectodermal dysplasia, Cleft lip/palate (EEC), and Ankyloblepharon-Ectodermal defects-Cleft (AEC) syndromes are ectodermal dysplasia (ED), orofacial clefting, limb anomalies. EEC AEC caused by heterozygous mutations in the transcription factor p63 encoded TP63. Here, we report a patient with an EEC/AEC syndrome-like phenotype, including ankyloblepharon, ED, cleft palate, ectrodactyly, syndactyly, additional hypogammaglobulinemia, growth delay. Neither...
Maximal standard-of-care (SOC) management could not stop the life-threatening progression of a necrotizing fasciitis induced by Panton-Valentine Leukocidin-producing Methicillin-Resistant Staphylococcus aureus (MRSA) in 12-year-old boy. Multi-route phage therapy was initiated along with antibiotics against aureus, Pseudomonas aeruginosa and Stenotrophomonas maltophilia , eventually leading to full recovery no reported adverse events.
This case report describes a 15-year-old patient with known congenital malformation syndrome and immune deficiency, presenting new-onset atrial fibrillation (AF) after recent diagnosis of an intrathoracic mass. Transthoracic echocardiography showed structurally functionally normal heart workup confirmed primary diffuse large B-cell lymphoma, pericardial left involvement on cardiac magnetic resonance imaging. Electrical cardioversion was successfully performed to convert the AF chemotherapy...
Multiple-access communication networks are being more and considered for use in acoustic underwater (AUW) channels. Spread-spectrum communications generally used if the signal-to-noise ratio (SNR) is low. They fight against intersymbol interference (ISI) caused by multipath propagation. This wide-band transmission robust jamming (traffic noise) or fading problems than PSK communications. And they particularly interesting a multi-user environment. The long propagation delays AUW channels...
Through an analytical study of both parallel interference cancellation and decorrelating detection in a DS-CDMA scheme, we derive simple improvement previous structures to achieve better bit error rate performance.
Liver metastases are rare in children with Wilms tumor (WT), and their impact on the outcome is unclear. The French cohort of patients WT presenting liver at diagnosis enrolled International Society Pediatric Oncology (SIOP) 2001 study was reviewed. From 2002 to 2012, 906 were SIOP2001 trial. Among them, 131 (14%) presented stage IV 18 (1.9%) had diagnosis. Isolated displayed four them. After preoperative chemotherapy, persistent disease reported 14/18 patients, 13 them underwent...
Secondary forms of diabetes are often understudied and underdiagnosed in children adolescents with cancer. The objectives our cohort study were to the incidence risk factors for hyperglycaemia leukaemia lymphoma patients.We retrospectively collected 15 years data from paediatric patients treated acute lymphoblastic (ALL), Hodgkin's (HL), non-Hodgkin's (NHL) immediately at cancer diagnosis. We studied univariate multivariate analyses.Our included 267 corresponding 179 ALL, 48 NHL 40 HL....
Different code division multiple access (CDMA) receiver architectures have already been proposed such as the maximum-likelihood or decorrelating detectors. However these are too complex to be implemented. Some other solutions based on subtractive interference cancellation (IC), which meanwhile better performance than conventional detectors, particularly attractive for hardware implementation. After a description and comparison of different IC methods, this article focuses implementation...