A5016165106- Tracheal and airway disorders
- Ear Surgery and Otitis Media
- Cytomegalovirus and herpesvirus research
- Head and Neck Anomalies
- Hearing, Cochlea, Tinnitus, Genetics
- Tumors and Oncological Cases
- Congenital Ear and Nasal Anomalies
- Airway Management and Intubation Techniques
- Teratomas and Epidermoid Cysts
- Herpesvirus Infections and Treatments
- Sinusitis and nasal conditions
- Vestibular and auditory disorders
- Ear and Head Tumors
- Head and Neck Surgical Oncology
- Dysphagia Assessment and Management
- Voice and Speech Disorders
- Congenital Diaphragmatic Hernia Studies
- Vascular Malformations and Hemangiomas
- Otolaryngology and Infectious Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Craniofacial Disorders and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Fetal and Pediatric Neurological Disorders
- COVID-19 and healthcare impacts
Délégation Paris 7
2014-2025
Université Paris Cité
2016-2025
Inserm
2014-2025
Hôpital Robert-Debré
2016-2025
Assistance Publique – Hôpitaux de Paris
2014-2025
NeuroDiderot
2018-2025
Hôpital de la Timone
2024
Assistance Publique Hôpitaux de Marseille
2024
Sorbonne Paris Cité
2013-2024
International Society of Nephrology
2020
Neurologic morbidity associated with congenital cytomegalovirus (CMV) infection is a major public health concern. The pathogenesis of cerebral lesions remains unclear. We report the neuropathologic substrates, immune response, and cellular targets CMV in 16 infected human fetal brains aged 23 to 28.5 gestational weeks. Nine cases were microcephalic, 10 had extensive cortical lesions, 8 hippocampal abnormalities, 5 showed olfactory bulb. density CMV-immunolabeled cells correlated presence...
To analyze the different factors affecting outcome of transnasal endoscopic repair choanal atresia (CA) in children.Retrospective study.Academic tertiary care children's hospital.Eighty patients (48 girls and 32 boys) aged 3 days to 17 years (mean age, 8 months) who presented with unilateral (n = 53: 37 right, 16 left) or bilateral 27) CA underwent surgery between September 1996 December 2005.All telescopes a microdebrider. Nasal tubes neonates nasal packing older children were removed after...
Congenital cytomegalovirus (CMV) infection is the leading infectious cause of neurologic disabilities and sensorineural hearing loss in children. Sensorineural prevalence CMV suggests a viral tropism for inner ear. Vestibular disorders induced by are underestimated. This largest most thorough study to assess incidence vestibular their correlation with thresholds children CMV.This retrospective assessed cohort 52 congenital impairment who received complete assessment. evaluation included...
The scalp-recorded amplitude-modulation following response (AMFR)” is gaining recognition as an objective audiometric tool, but little known about the neural sources that underlie this potential. We hypothesized, based on our human studies and single-unit recordings in animals, AMFR reflects interaction of multiple sources. tested hypothesis using animal model, unanesthetized rabbit. compared AMFRs recorded from surface brain at different locations before after administration agents likely...
ABSTRACT Objectives The aim of this research was to describe precisely prenatal ultrasound (US) features in congenital cytomegalovirus (CMV) infection. Methods We retrospectively evaluated the US descriptions cases CMV infection between 2004 and 2013. Results In 69 infections, related abnormalities were reported 30 (43.5%). There both extracerebral cerebral 16 cases, purely abnormal brain ten, two. About 19/30 presented 11 different sorts abnormalities, mainly hyperechogenic bowel (ten...
The concept of inflammation-induced sensitization is emerging in the field perinatal brain injury, stroke, Alzheimer disease, and multiple sclerosis. However, mechanisms underpinning this process remain unidentified.We combined vivo systemic lipopolysaccharide-induced or interleukin (IL)-1β-induced neonatal adult rodent cortical neurons to excitotoxic neurodegeneration with vitro IL-1β human neurodegeneration. Within these models, we assessed metabotropic glutamate receptors (mGluR)...
ABSTRACT Objective To assess the effectiveness, cost and cost‐effectiveness of four screening strategies for first‐trimester (T1) cytomegalovirus (CMV) primary infection (PI) in pregnant women France. Methods In a simulated population 800 000 (approximate number pregnancies each year France), using costs based on 2022, we compared CMV maternal strategies: Strategy S1, no systematic (current public health recommendations France); S2, 25–50% practice S3, universal medical S4, (as S3)...
To discuss the clinical, radiologic, and histopathologic characteristics of cervical bronchogenic cysts.Retrospective case study using a pathologic database at our institution.Pediatric hospital.Eight patients with cysts were identified in past 13 years (January 1994 to December 2007).The patients' clinical presentations surgical procedures are described.Two located on anterior midline, 5 anterolateral suprasternal, other was paraspinal. One corresponded an intralaryngeal extralaryngeal...
Objective: To evaluate the feasibility, duration and results of sedation by intrarectal pentobarbital oral alimemazine for auditory brain stem responses (ABR) steady-state (ASSR) recordings in children aged 2 to 5 years. Design: Prospective study. Study sample: 180 consecutive years, referred language retardation and/or behavioral problems, who could not be tested methods, underwent ABR ASSR recordings. The did spontaneously nap were sedated eventually potentiated alimemazine. Results: A...
Macrophages play a central role in tissue homeostasis and host defense. However, the properties of human macrophages non-diseased tissues remain poorly understood. Here, we characterized tonsil identified three subsets with distinct phenotype, transcriptome, life cycle, function. CD36hi were related to monocytes, while CD36lo showed features embryonic origin CD36int had mixed profile. scRNA-seq on non-human primate tonsils that monocyte recruitment did not pre-exist an immune challenge....