A5072386149- Glioma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Childhood Cancer Survivors' Quality of Life
- MRI in cancer diagnosis
- Radiation Therapy and Dosimetry
- Neuroblastoma Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Brain Tumor Detection and Classification
- Meningioma and schwannoma management
- Advances in Oncology and Radiotherapy
- Brain Metastases and Treatment
- Advanced Neuroimaging Techniques and Applications
- Renal and related cancers
- Lung Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Management of metastatic bone disease
- Acute Lymphoblastic Leukemia research
- Colorectal and Anal Carcinomas
- Radiation Dose and Imaging
- Chemotherapy-induced cardiotoxicity and mitigation
- Sarcoma Diagnosis and Treatment
Institut Claudius Regaud
2016-2025
Inserm
2014-2025
Université Toulouse III - Paul Sabatier
2015-2025
Université de Toulouse
2016-2025
Institut universitaire du cancer de Toulouse Oncopole
2015-2024
Centre Antoine Lacassagne
2023
Hôpital Rangueil
2023
Centre Léon Bérard
2009-2018
Centre de Radiothérapie Bayard
2017
Cognitive Neuroimaging Lab
2016
To integrate 3D MR spectroscopy imaging (MRSI) in the treatment planning system (TPS) for glioblastoma dose painting to guide simultaneous integrated boost (SIB) intensity-modulated radiation therapy (IMRT). For sixteen patients, we have simulated three types of dosimetry plans, one conventional plan 60-Gy conformational radiotherapy (3D-CRT), IMRT and 72-Gy SIB-IMRT. All MRSI metabolic maps were into TPS, using normalization with color-space conversion threshold-based segmentation. The...
Cardiac disease (CD) is one of the major side effects childhood cancer therapy, but until now little has been known about relationship between heart radiation dose (HRD) received during and risk CD.The cohort comprised 3162 5-year survivors cancer. Chemotherapy information was collected HRD estimated. There were 347 CDs in 234 patients, 156 them rated grade ≥3. Cox Poisson regression models used. The cumulative incidence any type CD at 40 years age 11.0% (95% confidence interval [CI],...
ABSTRACT Background and Purpose Working memory, a primary cognitive domain, is often impaired in pediatric brain tumor survivors, affecting their attention processing speed. This study investigated the long‐term effects of treatments, including surgery, radiotherapy (RT), chemotherapy (CT), on working memory tracts children with posterior fossa tumors (PFTs) using resting‐state functional MRI (rs‐fMRI) diffusion tractography. Methods included 16 medulloblastoma (MB) survivors treated...
Abstract Background Glioblastoma (GBM) systematically recurs after a standard 60 Gy radio-chemotherapy regimen. Since magnetic resonance spectroscopic imaging (MRSI) has been shown to predict the site of relapse, we analyzed effect MRSI-guided dose escalation on overall survival (OS) patients with newly diagnosed GBM. Methods In this multicentric prospective phase III trial, who had undergone biopsy or surgery for GBM were randomly assigned (SD) high (HD) an additional simultaneous...
The study objective was to develop a segmentation technique quantify breast tissue and total volume from magnetic resonance imaging (MRI) data obtain index (BTI) related density. Our goal is MR density improve cancer risk assessment for certain high-risk populations whom mammography of limited usefulness due high A semi-automatic 3D implemented based on fuzzy c-means (FCM) segment fibroglandular fat in the images. After validation phantom, our FCM first used test measures reproducibility two...
To determine event free and overall survival, long-term cognitive sequelae of children with standard-risk medulloblastoma (SRM) treated hyperfractionated radiotherapy, conformal reduced boost volume without chemotherapy, online quality assurance.Forty-eight patients (age 5 to 18 years) were included in the Medulloblastoma-Société Française d'Oncologie Pédiatrique (MSFOP 98) protocol (December 1998 October 2001). Patients received radiotherapy (HFRT; 36 Gy, 1 Gy/fraction twice per day)...
Glioblastoma, a high-grade glial infiltrating tumor, is the most frequent malignant brain tumor in adults and carries dismal prognosis. External beam radiotherapy (EBRT) increases overall survival but this still low due to local relapses, mostly occurring irradiation field. As ratio of spectra choline/N acetyl aspartate> 2 (CNR2) on MR spectroscopic imaging has been described as predictive for site relapse, we hypothesized that dose escalation these regions would increase control hence...
Thyroid carcinoma is a frequent complication of childhood cancer radiotherapy. The dose response to thyroid radiation now well established, but the potential modifier effect other factors requires additional investigation.This study aimed investigate role modifiers response.We followed cohort 4338 5-year survivors solid treated before 1986 over an average 27 years. received by gland and some anatomical sites during radiotherapy was estimated after reconstruction actual conditions in which...
ABSTRACT In 2005, the Paediatric Radiation Oncology Society (PROS), a multi‐professional association to promote radiotherapy for children and young people, was created. Its mission has been educate those involved in this field, improve standards of radiation oncology care children, adolescents, adults across globe, not least less privileged settings where majority world's most with cancer, live. Through regular congresses, joint meetings International (SIOP), PROS facilitated focus on...
<title>Abstract</title> Diffuse leptomeningeal glioneuronal tumour (DLGNT) is rare a neoplasm of the central nervous system, which occurs mainly in children and adolescents characterized by presence MAPK pathway alteration 1p deletion. Clinical, radiological molecular data from 20 patients diagnosed with DLGNT May 2001 to 2023 were collected. Clinical presentation was polymorphous, intracranial hypertension back pain as most common symptoms. Patients underwent multiple lines treatment...
The objective of this study was to determine whether systemic and regional, intensified treatment can improve the outcome children who present with a localized neuroblastoma (NB) MYCN amplification (MNA).Between 1990 2000, 610 NB were included in Localized Neuroblastoma 90 (NBL 90) NBL 94 from French Society Pediatric Oncology. Among them, 32 had MNA Stage II or III NB. During first period study, 20 (Group A) received postoperative conventional chemotherapy (CT) and/or radiotherapy (RT),...