A5041004778- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Palliative Care and End-of-Life Issues
- Family Support in Illness
- Radiation Therapy and Dosimetry
- Cancer Risks and Factors
- Adolescent and Pediatric Healthcare
- Effects of Radiation Exposure
- Glioma Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Advanced Radiotherapy Techniques
- Neuroblastoma Research and Treatments
- Cancer survivorship and care
- Chemotherapy-induced cardiotoxicity and mitigation
- Pharmaceutical studies and practices
- Global Cancer Incidence and Screening
- Lymphoma Diagnosis and Treatment
- BRCA gene mutations in cancer
- Management of metastatic bone disease
- Breast Cancer Treatment Studies
- Radiation Dose and Imaging
- Ethics and Legal Issues in Pediatric Healthcare
- Advances in Oncology and Radiotherapy
- Congenital Diaphragmatic Hernia Studies
- DNA Repair Mechanisms
Inserm
2016-2025
Université de Caen Normandie
2024-2025
Centre Hospitalier Universitaire de Caen Normandie
2024-2025
Université d'Angers
2019-2024
Centre François Baclesse
2021-2024
Centre Hospitalier Universitaire d'Angers
2018-2024
Centre de recherche en Epidémiologie et Santé des Populations
2016-2024
Université Paris-Saclay
2016-2024
Institut Jean Godinot
2024
Institut Curie
2023-2024
As new evidence is available, the International Late Effects of Childhood Cancer Guideline Harmonization Group has updated breast cancer surveillance recommendations for female survivors childhood, adolescent, and young adult cancer.
Abstract Anthracycline-based chemotherapy is associated with increased subsequent breast cancer (SBC) risk in female childhood survivors, but the current evidence insufficient to support early screening recommendations for survivors treated anthracyclines. In this study, we pooled individual patient data of 17,903 from six well-established studies, whom 782 (4.4%) developed a SBC, and analyzed dose-dependent effects anthracycline agents on developing SBC interactions chest radiotherapy. A...
Background Treatment summaries and a personalized survivorship care plans based on internationally approved, organ-specific follow-up recommendations are essential in preserving the health quality of life for cancer survivors. Cohorts made up survivors childhood have significant contributions to understanding early mortality, somatic late complications, psychosocial outcomes among former patients. New treatment protocols needed enhance survival reduce potential risk severity effects, working...
PURPOSE Childhood, adolescent, and young adult (CAYA) survivors of cancer are at risk nephrotoxicity. Surveillance guidelines important for timely diagnosis treatment these survivors, which could slow the progression to higher stages kidney dysfunction. METHODS The International Late Effects Childhood Cancer Guideline Harmonization Group established a multidisciplinary panel 34 experts from 11 countries. performed systematic literature reviews articles published between 1990 June 2023,...
Abstract Background Very few previous studies have addressed the question of colorectal cancer (CRC) after childhood treatment. We aimed to quantify roles radiation therapy and chemotherapy agents in occurrence subsequent CRC. Methods A nested case–control study was conducted using 36 CRC cases 140 controls selected from 7032 five‐year survivors French Childhood Cancer Survivor Study (FCCSS) cohort, treated 1945 2000 France. The dose‐distribution metrics at site doses individual...
Ameloblastic fibrosarcoma (AFS) is a rare malignant odontogenic tumor. We report 2 pediatric cases of AFS from different centers but reviewed by the same pathologist, which were unusual in that they chemosensitive. Management was wide surgical resection, chemotherapy, and adjuvant radiotherapy. One case local recurrence after incomplete surgery other an overlooked during earlier diagnosis ameloblastic fibroma. Both tumors responded very well to preoperative with reduction tumor size...
Late abdominal irradiation toxicity during childhood included renal damage, hepatic and secondary diabetes mellitus. We compared the potential of conformal radiotherapy (CRT), helical tomotherapy (HT) proton beam therapy (PBT) to spare organs at risk (pancreas, kidneys liver- OAR) in children undergoing irradiation.We selected with tumors who received more than 10 Gy abdomen. Treatment plans were calculated order keep dose OAR as low possible while maintaining same planned target volume...
Between 10% and 20% of childhood cancer survivors (CCS) experience impaired growth, leading to small adult height (SAH). Our study aimed quantify risk factors for SAH or growth hormone deficiency among CCS.The French CCS Study holds data on 7,670 treated before 2001. We analyzed self-administered questionnaire from 2,965 with clinical, chemo/radiotherapy medical records. was defined as an ≤ 2 standard deviation scores control values obtained a population health study.After exclusion 189...
Growth hormone (GH) deficiency is a common late effect of cranial irradiation. However, concerns have been raised that GH treatment might lead to an increased risk second neoplasm (SN).To study the impact on SN in French cohort survivors childhood cancer (CCS) treated before 1986.Cohort and nested case-control study.Of 2852 survivors, with median follow-up 26 years, 196 had received therapy (median delay from diagnosis: 5.5 years).Occurrence SN.In total, 374 developed SN, including 40 who...
Childhood cancer survivors (CCS) may require lifelong medical care due to late effects of treatments. Little is known about their healthcare utilization and expenditures at long-term especially in publicly funded health system. We aim estimate describe the among CCS France.A total 5319 five-year solid diagnosed before age 21 between 1945 2000 France were identified French Cancer Survivors Study cohort (FCCSS) registry. Information expenditure was taken from national data system 2011 2016,...