A5042347658- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Glioma Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Management of metastatic bone disease
- Bladder and Urothelial Cancer Treatments
- Urologic and reproductive health conditions
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Lipids, and Metabolism
- Brain Metastases and Treatment
- Advances in Oncology and Radiotherapy
- Cancer, Hypoxia, and Metabolism
- Childhood Cancer Survivors' Quality of Life
- Lung Cancer Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer therapeutics and mechanisms
- Advanced X-ray and CT Imaging
- MRI in cancer diagnosis
- Effects of Radiation Exposure
- Radiation Dose and Imaging
- Colorectal Cancer Surgical Treatments
- Cancer Immunotherapy and Biomarkers
Inserm
2016-2025
Nantes Université
2016-2025
Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers
2016-2025
Centre National de la Recherche Scientifique
2016-2025
Institut de Cancérologie de l'Ouest
2016-2025
Institut Génétique Nantes Atlantique
2012-2025
Université d'Angers
2019-2025
Centre Hospitalier René-Dubos
2001-2024
Unité en Sciences Biologiques et Biotechnologies de Nantes
2018-2024
Homi Bhabha National Institute
2024
Purpose Men with localized prostate cancer often are treated external radiotherapy (RT) over 8 to 9 weeks. Hypofractionated RT is given a shorter time larger doses per treatment than standard RT. We hypothesized that hypofractionation versus conventional fractionation similar in efficacy without increased toxicity. Patients and Methods conducted multicenter randomized noninferiority trial intermediate-risk (T1 2a, Gleason score ≤ 6, prostate-specific antigen [PSA] 10.1 20 ng/mL; T2b 2c, PSA...
LBA5000 Background: PEACE-1 demonstrated that combining ADT and docetaxel with abiraterone acetate plus prednisone (AAP) improves both overall survival (OS) radiographic progression-free-survival (rPFS) in men de novo mCSPC. The present analysis examines the second pre-planned primary endpoint of low-volume population: impact prostate irradiation (RT) receiving intensified systemic treatment. Methods: is an academic, multicentre, international, 2x2 design, phase 3 trial. co-primary endpoints...
LBA259 Background: Radiotherapy (RT) delivered in combination with androgen deprivation therapy (ADT) improve survival for patients prostate adenocarcinoma. RT given at a dose of 80 Gy is generally well tolerated but the occurrence grade 3-4 toxicities significantly more frequent than 70 Gy. Furthermore, ADT has been reported to increase RT-related toxicity. Thus, we aimed evaluate efficacy and safety escalation long term high-risk cancer patients. Methods: The GETUG-AFU 18 study, sponsored...
Background and purposeOligometastatic prostate cancer is a new emerging treatment field with only few prospective randomized studies published so far. Despite the lack of strong level I evidence, metastasis-directed therapies (MDT) are widely used in clinical practice, mainly based on retrospective small phase 2 large difference across centers. Pending results ongoing trials, there clear need for more consistent indications radiotherapy practices.Material methodsA European Society...
PURPOSE To determine the accuracy of large language models (LLMs) in generating appropriate treatment options for patients with early breast cancer on basis their medical records. MATERIALS AND METHODS Retrospective study using anonymized records BC presented during multidisciplinary team meetings (MDTs) between January and April 2024. Three generalist artificial intelligence (Claude3-Opus, GPT4-Turbo, LLaMa3-70B) were used to generate suggestions, which compared experts' decisions. The...
Abstract RAD51 is a key protein in the homologous recombination (HR) pathway of DNA double-strand break repair, and HR represents novel target for cancer therapy. Because imatinib (Gleevec) has been reported to reduce levels, we tested clonogenic survival RT112, H1299, PANC1, PC3 tumor cell lines varying p53 status normal GM05757 fibroblasts after exposure single agent (0–20 μmol/L; 0–72 hours). We also combined with damaging agents that are toxic RAD51-deficient cells, including ionizing...
Background Monoclonal antibodies (mAb) against GD2 ganglioside have been shown to be effective for the treatment of neuroblastoma. Beneficial actions are, however, associated with generalized pain due binding anti- mAbs peripheral nerve fibers followed by complement activation. Neuroblastoma cells that express also its O-acetyl derivative, O-acetyl- (OAcGD2). Hence, we investigated distribution OAcGD2 in human tissues using mAb 8B6 study cross-reactivity tissues. Methodology/Principal...
Automated atlas-based segmentation algorithms present the potential to reduce variability in volume delineation. Several vendors offer software that are mainly used for cranial, head and neck prostate cases. The study will compare contours produced by a radiation oncologist computed different automated bed cases, including femoral heads, bladder rectum. Contour comparison was evaluated metrics such as ratio, Dice coefficient Hausdorff distance. Results depended on of interest showed some...
During ultra-high dose rate (UHDR) external radiation therapy, healthy tissues appear to be spared while tumor control remains the same compared conventional rate. However, understanding of radiochemical and biological mechanisms involved are still discussed. This study shows how hydrogen peroxide (H2O2) production, one reactive oxygen species (ROS), could controlled by early heterogenous radiolysis processes in water during UHDR proton-beam irradiations. Pure was irradiated plateau region...
Abstract Background Glioblastoma (GBM) systematically recurs after a standard 60 Gy radio-chemotherapy regimen. Since magnetic resonance spectroscopic imaging (MRSI) has been shown to predict the site of relapse, we analyzed effect MRSI-guided dose escalation on overall survival (OS) patients with newly diagnosed GBM. Methods In this multicentric prospective phase III trial, who had undergone biopsy or surgery for GBM were randomly assigned (SD) high (HD) an additional simultaneous...