A5089562042- Osteoarthritis Treatment and Mechanisms
- Musculoskeletal pain and rehabilitation
- Pain Mechanisms and Treatments
- Total Knee Arthroplasty Outcomes
- Knee injuries and reconstruction techniques
- Liver Disease Diagnosis and Treatment
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Sports injuries and prevention
- Health, Environment, Cognitive Aging
- Rheumatoid Arthritis Research and Therapies
- Birth, Development, and Health
- Inflammatory mediators and NSAID effects
- Shoulder Injury and Treatment
- Pain Management and Placebo Effect
- Musculoskeletal synovial abnormalities and treatments
- Health disparities and outcomes
- Orthopaedic implants and arthroplasty
- Cardiovascular Effects of Exercise
- Gout, Hyperuricemia, Uric Acid
- Genetic Associations and Epidemiology
- Migration, Health and Trauma
- Child Abuse and Trauma
- Urticaria and Related Conditions
- Eicosanoids and Hypertension Pharmacology
- Nutritional Studies and Diet
University of Nottingham
2015-2024
Versus Arthritis
2015-2024
Public Health England
2023-2024
Queen's Medical Centre
2017-2024
NHS England
2023-2024
University of Bristol
2019-2023
Nottingham City Hospital
2015-2023
Associação Fundo de Incentivo à Pesquisa
2023
Nottingham Biomedical Research Centre
2018-2021
Center for Rheumatology
2018
The estimated worldwide prevalence of non-alcoholic fatty liver disease (NAFLD) in adults is 25%; however, young remains unclear. We aimed to identify the steatosis and fibrosis a sample participants recruited through Avon Longitudinal Study Parents Children (ALSPAC), based on transient elastography controlled attenuation parameter (CAP) score.
To determine the prevalence of knee pain, radiographic osteoarthritis (RKOA), total replacement (TKR) and associated risk factors in male ex-professional footballers compared with men general population (comparison group).1207 ex-footballers 4085 UK were assessed by postal questionnaire. Current pain was defined as or around knees on most days previous month. Presence severity RKOA standardised radiographs using Nottingham Line Drawing Atlas (NLDA) a subsample 470 491 comparison group. The...
The role of alcohol use in the development depression is unclear. We aimed to investigate whether dependence, but not high frequency or quantity consumption, during adolescence increased risk young adulthood.
Arsenic, a contaminant of groundwater and irrigated crops, is global public health hazard. Exposure to low levels arsenic through food extends well beyond the areas with high content in water.
Objectives. To evaluate the persistence and adherence on urate-lowering treatment (ULT) in primary care 5 years after an initial nurse-led of gout. Methods. One hundred gout patients initiated up-titrated ULT between March July 2010 were sent a questionnaire that elicited information current ULT, reasons for discontinuation if applicable, medication generic disease-specific quality-of-life measures 2015. They invited one visit at which height weight measured blood was collected serum uric...
Anxiety and depression are associated with increased pain responses in chronic states. The extent to which anxiety drives pain, or vice versa, remains an important question that has implications for analgesic treatment strategies. Here, the effect of existing on future osteoarthritis (OA) was investigated, potential mechanisms were studied animal model. Pressure detection thresholds, anxiety, assessed people (n = 130) without 100) painful knee OA. Separately, scores also measured twice over...
Neuropathic-like knee pain (NKP) is often reported in individuals with (KP), but the contribution of specific central and peripheral risk factors to NKP has not been studied previously. The aims present study were determine prevalence a community-derived sample KP identify associated NKP. A cross-sectional was undertaken (n = 9506) East Midlands community among responders (aged 40+ years) postal questionnaire. Questions included severity (numerical rating scale) type (neuropathic versus...
Abstract This study aimed to identify self-report correlates of central pain augmentation in individuals with knee pain. A subset participants (n = 420) the Knee Pain and related health In Community (KPIC) baseline survey undertook pressure detection threshold (PPT) assessments. Items measuring specific traits mechanisms were selected from based on expert consensus, face validity, item association underlying constructs measured by originating host questionnaires, adequate targeting, PPT...
Abstract Background Low and middle-income countries like India with a large youth population experience different environment from that of high-income countries. The Consortium on Vulnerability to Externalizing Disorders Addictions (cVEDA), based in India, aims examine environmental influences genomic variations, neurodevelopmental trajectories vulnerability psychopathology, focus externalizing disorders. Methods cVEDA is longitudinal cohort study, planned missingness design for yearly...
An important role for synovial pathology in the initiation and progression of knee osteoarthritis has been emphasised recently. This study aimed to examine whether ultrasonography-detected changes associate with pain (KP) a community population.A case-control was conducted compare people early KP (n = 298), established 100) or no 94) at baseline. Multinomial logistic regression used estimate odds ratio (OR) 95% confidence interval (CI) between groups adjusted radiographic (ROA) severity...
The incidence, progression and related risk factors for recent-onset knee pain (KP) remain uncertain. This study aims to examine the natural history of KP including incidence identify possible phenotypes their associated factors.A prospective community-based cohort men women aged 40 years or over within East Midlands region (UK) will be recruited via a postal questionnaire from general practices. enquire about: presence onset KP; severity (0–10 numerical rating scale (NRS)); catastrophizing...
Previous studies based on death certificates have found professional soccer players were more likely to die with neurodegenerative diseases, including dementia. Therefore, this study aimed investigate whether retired male would perform worse cognitive tests and be self-report dementia diagnosis than general population control men.A cross-sectional comparative was conducted between August 2020 October 2021 in the United Kingdom (UK). Professional recruited through different clubs England, men...
Twenty-five percent of the British population over age 50 years experiences knee pain. Knee pain can limit physical ability and cause distress bears significant socioeconomic costs. The objectives this study were to develop validate first risk prediction model for incident in Nottingham community internally within cohort externally Osteoarthritis Initiative (OAI) cohort. A total 1822 participants from who at followed 12 years. Of cohort, two-thirds (n = 1203) used model, one-third 619)...
To determine risk factors for 3 knee osteoarthritis (KOA) outcomes, pain (KP), radiographic KOA (RKOA), and total replacement (TKR) in professional footballers.This was a cross-sectional study involving postal questionnaire, followed by assessment subcohort of responders.Four thousand seven hundred seventy-five questionnaires were sent to retired footballers, who had played the English football league, 1207 responded. Of these, 470 underwent radiographs.Potential include age, body mass index...
Abstract Chronic musculoskeletal pain is a common problem globally. Current evidence suggests that maladapted central pathways are associated with chronicity, for example, in postoperative after knee replacement. Other factors such as low mood, anxiety, and tendency to catastrophize also important contributors. We aimed investigate brain imaging features underpin chronicity based on multivariate pattern analysis of cerebral blood flow (CBF), marker maladaptive changes. This was achieved by...
Abstract Background There is paucity of data on the prevalence ultrasound-detected synovial abnormalities in general population, and relationship between changes knee pain remains unclear. We examined ultrasound these features with radiographic osteoarthritis (ROA) a community sample. Methods Participants aged 50 years or over were from Xiangya Osteoarthritis Study, community-based cohort study. questioned about chronic underwent (1) ultrasonography both knees to determine presence...
AimTo explore risk factors that may influence knee pain (KP) through central or peripheral mechanisms.MethodsA questionnaire-based prospective community cohort study with KP defined as in around a on most days for at least month. Baseline prevalence, and one year incidence progression (KP worsening) were examined. Central (e.g., Pain Catastrophizing Scale (PCS)) significant injury) Adjusted odds ratio (OR) 95% confidence interval (CI) calculated using logistic regression. Proportional...