A5067180929- Eicosanoids and Hypertension Pharmacology
- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Musculoskeletal synovial abnormalities and treatments
- Total Knee Arthroplasty Outcomes
- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Diet and metabolism studies
- Rheumatoid Arthritis Research and Therapies
- Exercise and Physiological Responses
- Gut microbiota and health
- Cannabis and Cannabinoid Research
- Alcohol Consumption and Health Effects
- Inflammatory mediators and NSAID effects
- Healthcare and Venom Research
- Biochemical Acid Research Studies
- Gout, Hyperuricemia, Uric Acid
- Tendon Structure and Treatment
- Diet, Metabolism, and Disease
- Tryptophan and brain disorders
- Musculoskeletal Disorders and Rehabilitation
- Complementary and Alternative Medicine Studies
- Pain Mechanisms and Treatments
- Fatty Acid Research and Health
- Dietary Effects on Health
University of Nottingham
2019-2025
Versus Arthritis
2020-2025
Nottingham Biomedical Research Centre
2019-2025
Nottingham University Hospitals NHS Trust
2021-2023
National Institute for Health Research
2021-2022
National Health Service
2022
<h3>Importance</h3> Osteoarthritis is a prevalent, debilitating, and costly chronic disease for which recommended first-line treatment underused. <h3>Objective</h3> To compare the effect of an internet-based knee osteoarthritis vs routine self-management (ie, usual care). <h3>Design, Setting, Participants</h3> This randomized clinical trial was conducted from October 2018 to March 2020. Participants included individuals aged 45 years or older with diagnosis recruited existing primary care...
The endocannabinoid (EC) system has pleiotropic functions in the body. It plays a key role energy homeostasis and development of metabolic disorders being mediator relationship between gut microbiota host metabolism. In current study we explore functional interactions microbiome modulating inflammatory markers. Using data from 6 week exercise intervention (treatment n = 38 control 40) cross sectional validation cohort (n 35), measured associations 2-arachidonoylglycerol (2-AG), anandamide...
Abstract Background Specialized proresolution molecules (SPMs) halt the transition to chronic pathogenic inflammation. We aimed quantify serum levels of pro- and anti-inflammatory bioactive lipids in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients, identify potential relationships with innate responses clinical outcome. Methods Serum from 50 hospital admitted inpatients (22 female, 28 male) confirmed symptomatic SARS-CoV-2 infection 94 age- sex-matched controls...
Our goal was to probe the potential transcriptomic basis for relationship between plasma levels of specialized pro-resolving precursor, 17-hydroxy-docosahexaenoic acid (17-HDHA) and chronic pain. Participants with osteoarthritis (average age 62.3, 60% were female, n = 30) stratified by 17-HDHA self-reported pain scores. RNAs from CD14++/CD16-/CD66b-/HLA-DR+ (classical) monocytes sequenced differentially expressed mRNAs identified DESeq2. QIAGEN ingenuity pathway analysis top ranked canonical...
Abstract Background There is paucity of data on the prevalence ultrasound-detected synovial abnormalities in general population, and relationship between changes knee pain remains unclear. We examined ultrasound these features with radiographic osteoarthritis (ROA) a community sample. Methods Participants aged 50 years or over were from Xiangya Osteoarthritis Study, community-based cohort study. questioned about chronic underwent (1) ultrasonography both knees to determine presence...
Objective Chronic pain due to osteoarthritis (OA) is a major clinical problem, and existing analgesics often have limited beneficial effects and/or adverse effects, necessitating the development of novel therapies. Epoxyeicosatrienoic acids (EETs) are endogenous antiinflammatory mediators, rapidly metabolized by soluble epoxide hydrolase (EH) dihydroxyeicosatrienoic (DHETs). We undertook this study assess whether EH–driven metabolism EETs DHETs plays critical role in chronic joint associated...
Introduction Knee osteoarthritis (OA) is the most common joint disease worldwide. As of today, there are no disease-modifying drugs, but evidence that muscle strengthening exercises can substantially reduce pain and improve function in this disorder, one very well tested physiotherapy protocol ‘Better Management Patients with Osteoarthritis’ developed Sweden. Given high prevalence knee OA, a potentially cost-effective, digitally delivered approach to treat OA should be trialled. This study...
Aerobic exercise alters gut microbiome composition, yet the impact of gentle physiotherapy on and its relation to muscle strengthening physical function remains unexplored.
Highlights•Symptoms of anxiety and depression are associated with the gut microbiota.•Five bacterial genera depressive symptoms.•Associations were stronger in two chronic pain cohorts than controls.•A meta-analysis found Bifidobacterium lower symptoms.•Our results agree observations probiotic supplementation reducing anxiety.AbstractThe microbiome is a significant contributor to mental health, growing evidence linking its composition disorders. Gut signs both clinically diagnosed mood...
Objectives: The purpose of the literature review was to appraise evidence that an early physiotherapy intervention helps prevent surgery in selective musculoskeletal disorders. A search Google Scholar, Web Science, Scopus, and PubMed carried out utilizing terms (“physiotherapy”, “surgery” OR “exercise, surgery” “rehabilitation”, “surgery”).
 Methods: article titles abstracts were screened for eligibility included review. recent evidently emphasized has opted problems avoid delay...
Chronic pain is a major cause of disability and suffering in osteoarthritis (OA) patients. Endogenous specialised pro-resolving molecules (SPMs) curtail pro-inflammatory responses. One the SPM intermediate oxylipins, 17-hydroxydocasahexaenoic acid (17-HDHA, metabolite docosahexaenoic (DHA)), significantly associated with OA (Valdes et al., 2017). The aim this multidisciplinary work to develop mathematical model describe contributions enzymatic pathways (and genes that encode them) metabolism...
Abstract Background Specialised pro-resolution molecules (SPMs) halt the transition to chronic pathogenic inflammation. We aimed quantify serum levels of pro- and anti-inflammatory bioactive lipids in SARS-CoV-2 patients, identify potential relationships with innate responses clinical outcome. Methods Serum from 50 hospital admitted inpatients (22 female, 28 male) confirmed symptomatic infection 94 age sex matched cohort collected prior pandemic, were processed for quantification lipids....