A5008715238- Autoimmune and Inflammatory Disorders Research
- Inflammasome and immune disorders
- Osteomyelitis and Bone Disorders Research
- Immunodeficiency and Autoimmune Disorders
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Blood disorders and treatments
- Streptococcal Infections and Treatments
- Kawasaki Disease and Coronary Complications
- Ocular Diseases and Behçet’s Syndrome
- Hematopoietic Stem Cell Transplantation
- Allergic Rhinitis and Sensitization
- Respiratory and Cough-Related Research
- Mast cells and histamine
- Childhood Cancer Survivors' Quality of Life
- Adolescent and Pediatric Healthcare
- Bacterial Infections and Vaccines
- Acute Lymphoblastic Leukemia research
- Myasthenia Gravis and Thymoma
- Obsessive-Compulsive Spectrum Disorders
- Celiac Disease Research and Management
- Otitis Media and Relapsing Polychondritis
- Infective Endocarditis Diagnosis and Management
- Hematological disorders and diagnostics
- Rheumatoid Arthritis Research and Therapies
Azienda USL di Bologna
2021-2025
Policlinico S.Orsola-Malpighi
2014-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2023
University of Bologna
2005-2020
Istituto Giannina Gaslini
2019
University of Genoa
2019
Ospedale degli Infermi
2014
University of Turin
2006
University of Bari Aldo Moro
2006
University of Florence
2006
Abstract Objective The main aim of this study was to define the best treatment option for multisystem inflammatory syndrome in children (MIS-C) and analyse role anakinra. Methods This is a multicentre retrospective cohort study. Patients were treated according attending physician’s decision. patients divided into four groups on basis first at time admittance: (i) IVIG, (ii) IVIG methylprednisolone (≤2 mg/kg/day), (iii) with high-dose (>2 mg/kg/day) (iv) anakinra or without and/or...
Abstract Background Recurrent pericarditis (RP) is a complication (15–30%) of acute with an unknown etiology. Treatment regimen consists combination non-steroidal anti-inflammatory drugs (NSAIDs) and colchicine, the addition corticosteroids in resistant or intolerant cases. In last decade anakinra was shown as effective treatment patients colchicine steroid-dependent RP, initially anecdotal reports children more recently randomized trial. Canakinumab monoclonal antibody selectively blocking...
Evans syndrome (ES) is a rare but challenging condition, characterized by recurrent and refractory cytopenia episodes. Recent discoveries highlight that an appropriate diagnostic workup fundamental to identify underlying immune dysregulation, as primary immunodeficiencies or rheumatological disease. Here we describe the clinical features laboratory results of 12 pediatric patients affected ES referred Pediatric Onco-Hematology Unit Bologna. Patients experienced median four acute episodes...
To confirm the presence of different disease phenotypes pediatric SAPHO syndrome (pSAPHO) based on their skin manifestations in a large cohort Italian patients. pSAPHO were enrolled Eurofever Registry and data retrospectively analysed. Patients divided depending into an Acne-Hidradenitis suppurativa (HS) group Palmoplantar Pustulosis-Psoriasis Vulgaris (PPP-PV) compared with patients without (chronic non-bacterial osteomyelitis, CNO). Comparison frequencies between groups was performed by...
Juvenile idiopathic arthritis (JIA) is a chronic inflammatory of unknown origin which can be considered an autoimmune disease (AD). The aim this study to analyse the presence two or more diseases (polyautoimmunity) in patients suffering from JIA and evaluate occurrence ADs their families. Seventy-nine diagnosed with aged 0–21 years, admitted Paediatric Rheumatology Unit, Sant'Orsola-Malpighi Hospital, Bologna were screened for ADs. Parents asked about living relatives first second degree....
To build a prediction model for uveitis in children with JIA use current clinical practice.Data from the international observational Pharmachild registry were used. Adjusted risk factors as well predictors JIA-associated (JIA-U) determined using multivariable logistic regression models. The was selected based on Akaike information criterion. Bootstrap resampling used to adjust final optimism.JIA-U occurred 1102 of 5529 patients (19.9%). majority that developed JIA-U female (74.1%), ANA...
Objective. To describe the diagnosis and management of renal disease in three paediatric cases hypocomplementaemic urticarial vasculitis syndrome (HUVS).
To evaluate the impact of highly active antiretroviral therapy (HAART) on cancer incidence in HIV-infected children throughout a 20-year period.An observational population study was conducted 1,190 perinatally enrolled onto Italian Register for HIV Infection Children from 1985 to 2004 and never lost follow-up (total observation time, 10,037.66 years). Cancer rates were calculated pre-HAART (1985 1995), early HAART (1996 1999), late (2000 2004) periods compared using Poisson regression...
There are few data in the literature reporting evolution of hypogammaglobulinemia premature and full-term infants during first years life. The aim this study was to assess clinical immunological with hypogammaglobulinemia. We included 24 children (11 13 infants), aged 0-36 months, Fifteen (62.5%) had an isolated reduction IgG, 7 (29.2%) a decrease both IgG IgA 2 (8.3%) IgM. Normalization serum levels occurred at mean age 7.2 months. Full-term were divided into 3 groups based on normalization...
Background The use of Non-Pharmaceutical Interventions (NPIs) during the COVID-19 pandemic is debated. Understanding consequences these measures may have on vulnerable populations including children and adolescents important. Methods This a multicenter, quasi-experimental before-after study involving 12 hospitals North Italian Emilia-Romagna Region, with NPI implementation as intervention event. 3 years preceding (in March 2020) constituted pre-pandemic phase. subsequent 2 were further...
Wolman Disease (WD) is a severe multi-system metabolic disease due to lysosomal acid lipase (LAL) deficiency. We report on WD infant who developed an unusual hemophagocytic lymphohistiocytosis (HLH) phenotype related treated with sebelipase alfa. A male baby came our attention at six months of life for respiratory insufficiency and sepsis, abdominal distension, hepatosplenomegaly, diarrhea, growth retardation. HLH was diagnosed intravenous immunoglobulin, steroids, cyclosporine,...