A5035736675- Systemic Sclerosis and Related Diseases
- Autoimmune and Inflammatory Disorders Research
- Kawasaki Disease and Coronary Complications
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Systemic Lupus Erythematosus Research
- Inflammasome and immune disorders
- Dermatologic Treatments and Research
- Ocular Diseases and Behçet’s Syndrome
- Inflammatory Myopathies and Dermatomyositis
- Dermatological and Skeletal Disorders
- Eosinophilic Disorders and Syndromes
- Rheumatoid Arthritis Research and Therapies
- Autoimmune Bullous Skin Diseases
- Otitis Media and Relapsing Polychondritis
- Orthopedic Infections and Treatments
- Vasculitis and related conditions
- Adolescent and Pediatric Healthcare
- Renal Diseases and Glomerulopathies
- Osteomyelitis and Bone Disorders Research
- Bone health and treatments
- Bone health and osteoporosis research
- Skin Diseases and Diabetes
- Neonatal Health and Biochemistry
- Connective Tissue Growth Factor Research
- Musculoskeletal synovial abnormalities and treatments
University of Padua
2016-2025
University of Udine
2024-2025
Ospedale Santa Maria della Misericordia di Udine
2024-2025
University of Milan
2024
Vita-Salute San Raffaele University
2021-2024
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2018
Ospedale Maggiore
2018
Istituti di Ricovero e Cura a Carattere Scientifico
2018
Bambino Gesù Children's Hospital
2018
Instituto Nacional de Rehabilitación
2008
Objective. Juvenile localized scleroderma (JLS) includes a number of conditions often grouped together. With the long-term goal developing uniform classification criteria, we studied epidemiological, clinical and immunological features children with JLS followed by paediatric rheumatology dermatology centres.
Juvenile localized scleroderma is usually considered a disease that confined to the skin and subcutaneous tissue. We studied prevalence clinical features of extracutaneous manifestations in large cohort children with juvenile scleroderma.Data from multinational study on was used for this in-depth study. Clinical patients were compared those who had exclusively involvement.Seven hundred fifty entered One sixty-eight (22.4%) presented total 193 manifestations, as follows: articular (47.2%),...
To determine the clinical and immunologic features of systemic sclerosis (SSc) in a large group children describe evolution disease compare it with adult form.Data on 153 patients juvenile SSc collected from 55 pediatric rheumatology centers Europe, Asia, South North America were analyzed. Demographic, clinical, characteristics at onset, diagnosis, during course evaluated.Raynaud's phenomenon was most frequent symptom, followed by skin induration approximately 75% patients. Musculoskeletal...
Patients with scleroderma receiving Iloprost as a treatment for severe Raynaud’s phenomenon report reduction in skin tightness, suggesting that this drug inhibits fibrosis. Connective tissue growth factor (CTGF), recently described profibrotic cytokine, acts downstream and concert TGF-β to stimulate the fibrotic process is involved fibrosis seen scleroderma. Here we show Iloprost, acting by elevation of cAMP, blocks induction CTGF increase collagen synthesis fibroblasts exposed TGF-β. The...
Abstract Objective To develop criteria for the classification of systemic sclerosis (SSc) in children (juvenile SSc). Methods The study consisted 3 phases: 1) collection data on signs and symptoms actual patients with juvenile SSc that are useful defining involvement a particular organ; 2) selection parameters essential preparation set provisional (PCC) using 2 Delphi surveys; 3) consensus conference consisting steps: discussion rating clinical profiles 160 definite SSc, possible or other...
Juvenile localized scleroderma is a chronic progressive fibrotic disorder of the skin that causes permanent disability and aesthetic damage. This study was undertaken to assess safety efficacy methotrexate (MTX) in treatment juvenile scleroderma.In this double-blind study, patients with active were randomized (2:1) receive oral MTX (15 mg/m², maximum 20 mg) or placebo once weekly, for 12 months until failure. Both groups received prednisone (1 mg/kg/day, 50 first 3 months. A target lesion...
Objective. Pharmacokinetic studies have shown that the biological effect of triamcinolone acetonide (TA) is equivalent to hexacetonide (TH), if used at double dosage. In this study we compared efficacy intra-articular TA a dose twice TH in symmetrically involved joints, children with juvenile idiopathic arthritis (JIA).
To evaluate the safety and efficacy of abatacept in patients with severe juvenile idiopathic arthritis (JIA)-related uveitis refractory or intolerant to immunosuppressive anti-tumor necrosis factor alpha (anti-TNFalpha) agents.Patients JIA-related anti-TNFalpha agents were treated intravenous (10 mg/kg monthly). Side effects, frequency flares, ocular complications before after treatment reported.Seven (6 females 1 male) a mean duration 11.6 years entered study. All had failed previous...
Objective. To evaluate the efficacy of mycophenolate mofetil (MMF) in treatment severe refractory juvenile localized scleroderma (JLS). Methods. A retrospective chart review was performed patients with JLS who had been treated MMF after failure a combination MTX and corticosteroids for at least 4 months, or whose concomitant extracutaneous manifestations. Outcome assessed through clinical examination thermography. Adverse events were recorded. Results. Ten (six females four males) enrolled...
Objective. To evaluate safety and efficacy of adalimumab (ADA) infliximab (IFX) for the treatment juvenile idiopathic arthritis-related anterior uveitis (JIA-AU). Methods. Starting January 2007, patients with JIA-AU treated IFX ADA were managed by a standard protocol data entered into National Italian Registry (NIR). At baseline, all refractory to immunosuppressive and/or corticosteroid-dependent. Data recorded every 3 months included course, number/type ocular complications, drug-related...
<h3>Background:</h3> Most of the available documentation in literature on ocular involvement localised scleroderma (LS) are descriptions single cases adult patients. This article reports frequency and specific features a large cohort children with juvenile LS (JLS). <h3>Methods:</h3> Data from large, multi-centre, multinational study were used to collect analyse information involvement. <h3>Results:</h3> 24 out 750 patients (3.2%) revealed significant 16 female 8 male. (66.7%) had "en coup...
It is estimated that around 20% of patients with systemic lupus erythematosus (SLE) have their onset in childhood but there been conflicting data about the prevalence and severity clinical features different age classes. We conducted this study to analyse pediatric SLE (pSLE) infancy, prepubertal postpubertal age. The charts followed at Department Pediatrics, University Padua, who met criteria for diagnosis, were reviewed. Patients divided into three groups based on disease onset: group A, <...
Anti-TNF-α agents have significantly changed the management of juvenile idiopathic arthritis (JIA). We evaluated safety and efficacy adalimumab (ADA) infliximab (IFX) for treatment JIA-associated uveitis in patients treated ≥ 2 years.Patients with IFX ADA were managed by a standardized protocol data entered ORCHIDEA registry. At baseline, all refractory to standard immunosuppressive or corticosteroid-dependent. Data recorded every 3 months course, number/type ocular flares complications,...
Objective. Abatacept (ABA) has recently been proposed as second-line treatment in patients with juvenile idiopathic arthritis (JIA)–associated uveitis refractory to anti–tumor necrosis factor-α (anti-TNF) agents, but little is known about its efficacy a first-line approach. The aim of the present study was compare safety and ABA biological agent (ABA-1) that after 1 or more anti-TNF agents (ABA-2), severe JIA-related uveitis. Methods. In this multicenter study, we collected data on treated...
Multisystem Inflammatory Syndrome in Children (MIS-C) is a known severe condition affecting children previously exposed to SARS-CoV-2. The aim of our study was describe the early cardiac abnormalities patients with MIS-C, evaluated by speckle tracking echocardiography (STE) and MRI (CMR). Clinical, laboratory microbiological data were measured for all patients. All underwent standard transthoracic echocardiography, STE analysis left ventricle global longitudinal strain (GLS). Seventeen (75%)...
Objective. The aim of this study was to define the clinical utility infrared thermography in disease activity detection localized scleroderma (LS).
Objectives. To determine whether demographic, clinical and immunological features may predict the outcome in juvenile SSc (JSSc). Methods. Clinical laboratory characteristics of patients with JSSc collected from paediatric rheumatology centres worldwide were analysed. First, univariate tests identified those significantly related fatal outcome, then multivariate logistic regression analysis was applied to predictors mortality. Results. One hundred thirty-four 40 eligible for analysis....
Abstract Introduction Interleukin-1 (IL-1) blockade is the treatment of choice cryopyrin associated periodic syndromes (CAPS). Anti-IL-1 monoclonal antibody (canakinumab) was recently registered. However no clear data are available on optimal schedule administration this drug. The aim present study to analyse impact canakinumab CAPS patients in daily clinical practice and identify best according age phenotype. Methods 13 (10 children 3 young adults) treated with were followed for 12 months....
Abstract Objective The main aim of this study was to define the best treatment option for multisystem inflammatory syndrome in children (MIS-C) and analyse role anakinra. Methods This is a multicentre retrospective cohort study. Patients were treated according attending physician’s decision. patients divided into four groups on basis first at time admittance: (i) IVIG, (ii) IVIG methylprednisolone (≤2 mg/kg/day), (iii) with high-dose (&gt;2 mg/kg/day) (iv) anakinra or without and/or...
<b>Background:</b> Antibodies against cyclic citrullinated peptide (anti-CCP) are considered to be specific for rheumatoid arthritis (RA). <b>Objective:</b> To assess the clinical significance of anti-CCP in a cohort patients with juvenile idiopathic (JIA). <b>Methods:</b> Anti-CCP were tested by an enzyme linked immunosorbent assay (ELISA) serum samples from 109 JIA (30 boys, 79 girls), mean age 8.7 years (range 0.6–20.3) and disease duration 3.6 3 months 15.6 years). As control groups,...