A5046786806- Systemic Sclerosis and Related Diseases
- Autoimmune and Inflammatory Disorders Research
- Adolescent and Pediatric Healthcare
- Dermatological and Skeletal Disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Eosinophilic Disorders and Syndromes
- Vasculitis and related conditions
- Inflammasome and immune disorders
- Acute Lymphoblastic Leukemia research
- Pharmaceutical studies and practices
- Rheumatoid Arthritis Research and Therapies
- Childhood Cancer Survivors' Quality of Life
- Clostridium difficile and Clostridium perfringens research
- Kawasaki Disease and Coronary Complications
- Blood Coagulation and Thrombosis Mechanisms
- Drug-Induced Adverse Reactions
- Dupuytren's Contracture and Treatments
- Systemic Lupus Erythematosus Research
- Streptococcal Infections and Treatments
- Immunodeficiency and Autoimmune Disorders
- Renal Diseases and Glomerulopathies
- Nosocomial Infections in ICU
- Otitis Media and Relapsing Polychondritis
- Child and Adolescent Health
- Diabetes and associated disorders
Charles University
2013-2024
General University Hospital in Prague
2011-2024
Institute of Clinical and Experimental Medicine
2007-2020
Institute of Rheumatology
2014-2017
Nemocnica Malacky
2015
Istituti di Ricovero e Cura a Carattere Scientifico
2007-2013
University of Hradec Králové
2010
University of Padua
2008
Instituto Nacional de Rehabilitación
2008
University of Manchester
2007
Tumor necrosis factor (TNF) has a pathogenic role in juvenile rheumatoid arthritis. We evaluated the efficacy and safety of adalimumab, fully human monoclonal anti-TNF antibody, children with polyarticular-course arthritis.Patients 4 to 17 years age active arthritis who had previously received treatment nonsteroidal antiinflammatory drugs underwent stratification according methotrexate use 24 mg adalimumab per square meter body-surface area (maximum dose, 40 mg) subcutaneously every other...
To determine the clinical and immunologic features of systemic sclerosis (SSc) in a large group children describe evolution disease compare it with adult form.Data on 153 patients juvenile SSc collected from 55 pediatric rheumatology centers Europe, Asia, South North America were analyzed. Demographic, clinical, characteristics at onset, diagnosis, during course evaluated.Raynaud's phenomenon was most frequent symptom, followed by skin induration approximately 75% patients. Musculoskeletal...
Objectives. To determine whether demographic, clinical and immunological features may predict the outcome in juvenile SSc (JSSc). Methods. Clinical laboratory characteristics of patients with JSSc collected from paediatric rheumatology centres worldwide were analysed. First, univariate tests identified those significantly related fatal outcome, then multivariate logistic regression analysis was applied to predictors mortality. Results. One hundred thirty-four 40 eligible for analysis....
Objectives. To study G→A −238 and −308 polymorphisms in the promoter region of tumour necrosis factor (TNF) α gene patients with juvenile idiopathic arthritis (JIA). We analysed whether there were any associations between these type JIA and/or clinical course disease two populations.
There is a lack of published evidence on the importance methotrexate (MTX) dose and route administration both its efficacy adverse events in children with Juvenile Idiopathic Arthritis (JIA). We aimed to document our clinical practice based treat-to-target approach order support concept that better therapeutic effect achieved an optimal parenteral MTX associated clinically acceptable effects comparable those reported for oral treatment. Study inclusion criteria were indication new therapy...
Objective To evaluate the baseline clinical characteristics of juvenile systemic sclerosis (SSc) patients in international SSc inception cohort, and to compare these between classically defined diffuse cutaneous (dcSSc) limited (lcSSc) subtypes among those with overlap features. Methods A cross‐sectional study was performed using visit data. Information on demographic characteristics, organ system evaluation, treatment, patient‐ physician‐reported outcomes extracted summary statistics...
Juvenile systemic sclerosis is an orphan disease. Currently, the majority of juvenile cohort studies are retrospective in design without standardized assessment. This study was conducted prospectively to investigate difference manifestations limited cutaneous and diffuse subtypes. An additional aim compare these data other cohorts a large adult cohort.
Objectives Long-term safety and efficacy of adalimumab among patients with juvenile idiopathic arthritis (JIA) was evaluated through 6 years treatment. Methods Children aged 4–17 polyarticular JIA were enrolled in a phase III, randomised-withdrawal, double-blind, placebo-controlled trial consisting 16-week open-label lead-in period, 32-week randomised double-blind period 360-week long-term extension. Patients stratified by baseline methotrexate use. Adverse events (AEs) monitored,...
Objective. To investigate whether methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms erythrocyte concentration of methotrexate (EMTX) could serve as predictors (MTX) efficacy toxicity in patients with juvenile idiopathic arthritis (JIA). Methods. Genetic analyses EMTX folate assessment were performed 69 JIA aged 2.5–19.6 years (30 male) treated MTX using a dose-escalation protocol classified full responders (disease inactivity; n = 51) or nonresponders (< 30%...
Abstract Objectives To investigate the relationship between Clostridium (Clostridioides) difficile strain characteristics and C. infection (CDI) outcome. Methods Between October December 2017, 16 hospitals collected epidemiological data according to European Centre for Disease Prevention Control (ECDC) surveillance protocol CDI. isolates were characterized by ribotyping, toxin genes detection antibiotic susceptibility testing metronidazole, vancomycin moxifloxacin. Results The overall mean...
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Objectives: Juvenile systemic sclerosis is a rare childhood disease. Three disease activity indices have been published for adult patients with sclerosis: the European Scleroderma Study Group Index, modified version of Index and revised Trials Research index. The objective this study was to determine feasibility performance three in prospectively followed cohort juvenile sclerosis. Methods: analysis selected from prospective international inception enrolling patients. correlation physicians’...
Bacteraemia of the donor is not considered to be contraindication organ procurement. On other hand, infection solid transplant recipients remains a major cause their morbidity and mortality. When using organs from bacteraemic donors, individual risks need assessed appropriate antibiotic treatment applied. In this case series we report several serious donor–derived infectious complications in four out five different one single early posttransplant period. Donor-transmitted multi-drug...
Úvod: Přes pokroky v diagnostice a léčbě infekční endokarditidy (IE) přetrvává vysoká nemocnost i úmrtnost tohoto onemocnění. Cílem práce bylo posoudit vývoj spektra nemocných s IE hospitalizovaných kardiocentru terciární nemocnice identifikovat rizikové faktory mortality recidivy IE.Soubor metody: Retrospektivně byl analyzován soubor 334 podle modifikovaných diagnostických kritérií (Duke), kteří byli hospitalizováni Kardiocentru IKEM Praze letech 2000-2013. Uvedený časový interval jsme...
To evaluate bone quality by means of quantitative ultrasonometry (QUS) in children with juvenile idiopathic arthritis (JIA).Seventy [37 oligoarticular JIA, mean age (+/-s.d.) 10.54 +/- 3.42 yr; and 33 polyarticular rheumatoid factor negative (+/- s.d.) 11.33 2.88 yr] were enrolled. Quantitative was measured on both heels a Cuba Clinical portable device. Body height, weight body mass index recorded together disease duration cumulative dose prednisone.The lowest QUS parameters observed JIA (P<...