A5045446404- Autoimmune and Inflammatory Disorders Research
- Adolescent and Pediatric Healthcare
- Immunodeficiency and Autoimmune Disorders
- Rheumatoid Arthritis Research and Therapies
- Eosinophilic Disorders and Syndromes
- Kawasaki Disease and Coronary Complications
- Family and Disability Support Research
- Vasculitis and related conditions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Coronary Artery Anomalies
- Streptococcal Infections and Treatments
- Immune Cell Function and Interaction
- Child and Adolescent Health
- Musculoskeletal synovial abnormalities and treatments
- Neurogenetic and Muscular Disorders Research
- Healthcare Systems and Public Health
- Temporomandibular Joint Disorders
- Eosinophilic Esophagitis
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- Sarcoidosis and Beryllium Toxicity Research
- Adenosine and Purinergic Signaling
- Acute Lymphoblastic Leukemia research
- Hypertrophic osteoarthropathy and related conditions
- Macrophage Migration Inhibitory Factor
Children's Clinical University Hospital
2017-2024
Riga Stradiņš University
2011-2024
Azienda Ospedaliera Universitaria Pisana
2022
University of Pisa
2022
Temple Street Children's University Hospital
2013
Objective. To seek insights into the heterogeneity of macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (sJIA) through analysis a large patient sample collected in multinational survey. Methods. International pediatric rheumatologists and hemato-oncologists entered their data, retrospectively, Web-based database. The demographic, clinical, laboratory, histopathologic, therapeutic, outcome data were analyzed relation to (1) geographic location caring...
Background and Objectives: Since the first cases of multisystem inflammatory syndrome in children (MIS-C) April 2020, diagnostic challenge has been to recognize this differentiate it from other clinically similar pathologies such as Kawasaki disease (KD) toxic shock (TSS). Our objective is compare clinical signs, laboratory data instrumental investigations between patients with MIS-C, KD TSS. Materials Methods: This retrospective observational study was conducted at Children’s Clinical...
Background and Objectives: Systemic juvenile idiopathic arthritis (sJIA) is a distinctive JIA subtype with mostly nonspecific systemic clinical features, which can be diagnostic challenge. This study aimed to analyze our experience sJIA in Latvia for twelve years: assessing epidemiological characteristics, the efficacy of therapy, disease outcomes, including development macrophage activation syndrome (MAS). Materials methods: descriptive we conducted retrospective case review all patients...
Our objective was to develop and validate cutoff values in the systemic Juvenile Arthritis Disease Activity Score 10 (sJADAS10) that distinguish states of inactive disease (ID), minimal activity (MDA), moderate (MoDA), high (HDA) children with juvenile idiopathic arthritis, based on subjective state assessment by treating pediatric rheumatologist.
Eosinophilic granulomatosis with polyangiitis (EGPA; formerly known as Churg-Strauss syndrome) is classified an antineutrophil cytoplasmic antibody (ANCA)-associated small vessel vasculitis. It a multisystem disorder and can affect every organ system. EGPA rare disease, estimated prevalence of 1/70,000-100,000 in Europe. As its onset usually occurs adulthood, data from pediatric patients are limited. We present here very practical clinical case involving patient. Presently, on mepolizumab...
Temporomandibular joint (TMJ) arthritis is seen very often (38-87 %) in children with juvenile idiopathic (JIA). With contrast enhanced magnetic resonance imaging (MRI) we can detect more cases of TMJ than ever before. Previous studies show that HLA II class alleles may have protective or risk importance JIA subtypes. Our objective to identify and protection patients arthritis.During the period from 2010 2015 MRI for was performed 85 who were genotyped HLA- DRB1; DQB1 DQA1 using RT-PCR...
The aim of this article is to highlight the significance actively involving young children in their own healthcare and paediatric planning. Based on a study conducted hospital setting, which revealed lack personalized care inadequate understanding among younger children, discusses potential benefits empowering patients. theoretical framework explores various dimensions, including child-centred care, communication strategies, child development, impact decision-making processes. By fostering...
<h3>Background</h3> Rheumatic fever (RF) is an autoimmune disease which pathogenesis based on the response of cellular and humoral immune system, that develops after Group A beta hemolytic Streptococci infection with following 45% obtained heart (Guilherme L, 2011). One most typical clinical manifestations polyarthritis. So far it found genetic polymorphisms may affect system functions phenotype RF manifestations. Since cytokines are central molecules, cytokine gene promoter can production...
Methods Patient data were collected retrospectively by pediatric rheumatologists (PR) or hemato-oncologists (PHO). Clinical features, treatments and outcome compared between groups Mann-Whitney chisquare tests. “Severe course” was defined as ICU admission death. Results 362 patients with MAS in sJIA 95 investigators from 33 countries. 179 (49.4%) enrolled Europe (EU), 72 (19.9%) North America (NA) 111 (30.7%) other continents (OC). 79 (21.8%) included PHO. HP detected 44% of not looked for...
Temporomandibular joint (TMJ) involvement is seen very often (17-87%) in children with juvenile idiopathic arthritis that can lead to compromised craniomandibular function, dentofacial aestethics and morphology. Contrast enhanced MRI the golden standart for diagnosis of TMJ (Argyropoulou, 2009). Previous studies show HLA II class alleles may have protective or risk importance JIA subtypes (Hollenbach, 2010).
<h3>Background</h3> Juvenile idiopathic arthritis (JIA) is group of heterogenous diseases [1]. Inflammatory cytokines, like Iiterleukin 6 (IL-6), IL-1 and tumor necrosis factor alpha (TNF-a) their regulatory gene polymorphisms can affect cytokine production, inflammatory processes disease outcome [2-4]. <h3>Objectives</h3> To determine the association <i>IL6</i>, <i>IL1A</i> <i>TNFA</i> SNPs with JIA. <h3>Methods</h3> All 107 JIA patients (28 seronegative 12 seropositive polyarthritis, 23...
A multinational collaborative effort aimed to develop a new set of criteria for macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (sjia) is ongoing. The data-collection phase the project has been recently completed
<h3>Background</h3> Juvenile idiopathic arthritis (JIA) is heterogenous group of diseases and it most common rheumatic disease in children. Inflammatory cytokines their regulatory gene polymorphisms are important the pathogenesis JIA. Interleukin 6 (IL-6) significant inflamation [1] whereas IL-10 has anti-inflammatory activity [2]. Protein tyrosine phosphatase non-receptor 22 (PTPN22) impact on T B cell regulation activation [3]. One single nucleotide (SNP) substitution within certain can...
<h3>Background</h3> Juvenile idiopathic arthritis (JIA) is the most common autoimmune heterogenic diseases group of unknown etiology with7 subtypes. There are markedly high prevalence temporomandibular joint (TMJ) involvement- 17 - 87% depending on population and examination method (1). Contrast enhanced magnetic resonance imaging (MRI) considered optimal for TMJ evaluation. Beside systemic therapy intraarticular (i/a) steroid injections night splints used in a cases (2). <h3>Objectives</h3>...
Hypereosinophilic syndrome (HES) is a heterogeneous group of disorders characterized by peripheral blood eosinophilia 1.5 × 109/L (1,500/μL) or greater, with evidence end-organ damage attributable to (e.g., heart, liver lung) no other cause for the [1]. Eosinophilic granulomatosis polyangiitis (EGPA) rare disorder that may affect multiple organ systems (lungs, kidneys, nervous system). The hypereosinophilia in and tissues, inflammation vessels (vasculitis), development inflammatory nodular...
Introduction Kawasaki disease (KD) is an acute febrile illness of early childhood, characterised by vasculitis the coronary and medium-sized arteries. The incidence differs worldwide, but KD has not been established in Latvia. aim study was to describe epidemiological characteristics estimate rate resistance initial treatment among hospitalised children Material methods a descriptive, population-based study, which used hospital discharge records patients < 18 years old diagnosed with...
Eosinophilic granulomatosis with polyangiitis (EGPA; formerly known as Churg-Strauss syndrome) is classified an anti-neutrophil cytoplasmic antibody (ANCA)-associated small vessel vasculitis. It a multisystem disorder and can affect every organ system. EGPA rare disease, estimated prevalence of 1/70,000–100,000 in Europe. As its onset usually occurs adulthood, data from paediatric patients are limited. We present here very practical clinical case involving patient. Presently, on mepolizumab...
Abstract Background Adenosine deaminase 2 (ADA2) deficiency is an inherited autoinflammatory syndrome caused by a defect in the ADA2 gene. Most common manifestations include peripheral vasculopathy, early-onset stroke, immunodeficiency, and haematological manifestations. Patients with pathogenic variants that are more detrimental to ADA2’s enzymatic function (e.g. frameshift) have been reported be prone developing hematological phenotype. We report here case of 13-year-old Caucasian girl...