A5029180831- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- CAR-T cell therapy research
- Long-Term Effects of COVID-19
- Immunodeficiency and Autoimmune Disorders
- T-cell and B-cell Immunology
- Hepatitis C virus research
- Peripheral Neuropathies and Disorders
- Pregnancy and Medication Impact
- Vaccine Coverage and Hesitancy
- Systemic Lupus Erythematosus Research
- Tryptophan and brain disorders
- Biomedical and Engineering Education
- Viral Infections and Immunology Research
- COVID-19 Impact on Reproduction
- Multiple Sclerosis Research Studies
- Antifungal resistance and susceptibility
- Food Allergy and Anaphylaxis Research
- SARS-CoV-2 detection and testing
- Parvovirus B19 Infection Studies
- Nanowire Synthesis and Applications
- COVID-19 diagnosis using AI
- Alcoholism and Thiamine Deficiency
- Prion Diseases and Protein Misfolding
Hospital Clínic de Barcelona
2019-2025
Universitat de Barcelona
2019-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2021-2025
Fundació Clínic per a la Recerca Biomèdica
2024
Hospital Sant Joan de Déu Barcelona
2022
Banc de Sang i Teixits
2019
Universitat Autònoma de Barcelona
2015
Vall d'Hebron Institut de Recerca
2015
Recently published studies have found an impaired immune response after SARS-CoV-2 vaccination in solid organ recipients. However, most of these not assessed cellular responses liver and heart transplant We prospectively studied recipients eligible for vaccination. Patients with past history infection or detectable antibodies (IgM IgG) were excluded. IgM/IgG ELISpot against the S protein 4 weeks receiving second dose mRNA-1273 (Moderna) vaccine. Side effects, troponin I, tests anti-HLA...
A national outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 Wuhan, China, rapidly evolving to the disease (COVID-19) pandemic. Neurologic complications COVID-19 include headache, confusion, hyposmia, and dysgeusia,[1][1] with
This study explored the effects of antimicrobiota vaccines on acquisition Borrelia and Rickettsia, microbiota composition Ixodes ricinus ticks. Using a murine model, we investigated immunological responses to live Staphylococcus epidermidis multi-antigenic peptide (MAP) vaccines. Immunized mice were infected with either afzelii or Rickettsia helvetica, subsequently infested pathogen-free I. nymphs. We monitored tick feeding behavior, survival rates, infection levels. Additionally, employed...
Background Humoral and cellular immune responses are known to be crucial for patients recover from COVID-19 protect them against SARS-CoV-2 reinfection once infected or vaccinated. Objectives This study aimed investigate humoral T cell vaccination in with autoimmune diseases after the second third vaccine doses while on rituximab their potential protective role reinfection. Methods Ten COVID-19-naïve were included. Three time points used monitoring responses: pre-vaccine exclude virus...
Antibodies to phospholipids (aPL) and associated proteins are a hallmark in the diagnosis of anti-phospholipid syndrome (APS). Those included classification criteria lupus anticoagulant (LA) IgG IgM isotypes anticardiolipin (aCL) anti-beta-2 glycoprotein I (β2GPI) antibodies. Non-classification markers such as autoantibodies that recognize phosphatidylserine/prothrombin (aPS/PT) complex have been proposed biomarkers for APS. Studies aPS/PT antibodies shown strong correlation clinical...
Aims Atypical lymphocytes circulating in blood have been reported COVID-19 patients. This study aims to (1) analyse if patients with reactive (COVID-19 RL) show clinical or biological characteristics related outcome; (2) develop an automatic system recognise them objective way and (3) their immunophenotype. Methods Clinical laboratory findings 36 were compared between those showing RL (18) without (18). Blood samples analysed Advia2120i stained May Grünwald-Giemsa. Digital images acquired...
In people with multiple sclerosis (pwMS), concern for potential disease exacerbation or triggering of other autoimmune disorders contributes to vaccine hesitancy. We assessed the humoral and T-cell responses SARS-CoV-2 after mRNA vaccination, changes in activity, development antibodies against central peripheral nervous system antigens.This was a prospective 1-year longitudinal observational study pwMS control group patients inflammatory neurologic (OIND) who received an vaccine. Blood...
<b><i>Background:</i></b> Recurrence of immunoglobulin (Ig)A nephropathy (rIgAN) is a growing cause kidney allograft dysfunction. This study was aimed at investigating factors associated with rIgAN and the subsequent progression to end-stage renal disease (ESRD). <b><i>Methods:</i></b> Retrospective including consecutive patients IgA (IgAN) who received transplant in our center between 1992 2016 had biopsy by clinical indication. The date...
Introduction: Prevalence estimates of SARS-CoV-2 infection in Africa are limited, particularly among pregnant women and those living with HIV. This study assessed the seroprevalence antibodies Mozambican HIV-infected during first year pandemic, before COVID-19 vaccines were deployed country. Setting: The was conducted Manhiça district, a semirural area southern Mozambique. Methods: A prospective cohort including HIV from November 2019 to June 2021. Women enrolled at antenatal care clinic...
Purpose To describe SARS-CoV-2 infection outcome in unvaccinated children and young adults with inborn errors of immunity (IEI) to compare their specific acute long-term immune responses a sex-, age-, severity-matched healthy population (HC). Methods Unvaccinated IEI patients up 22 years old infected were recruited along cohort HC. serology ELISpot performed the phase (up 6 weeks) at 3, 6, 9, 12 months. Results Twenty-five (median age 14.3 years, min.-max. range 4.5-22.8; 15/25 males;...
Cellular and humoral immune responses are essential for COVID-19 recovery protection against SARS-CoV-2 reinfection. To date, the evaluation of has mainly focused on antibody detection, generally disregarding cellular response, or placing it in a secondary position. This phenomenon may be explained by complex nature assays needed to analyze immunity compared with technically simple automated detection antibodies. Nevertheless, large body evidence supports relevance T cell’s role SARS-CoV-2,...
Background. In kidney transplant recipients, there is discordance between the development of cellular and humoral response after vaccination against SARS-CoV-2. We sought to determine interplay 2 arms adaptive immunity in a 3-dose course mRNA-1273 100 μg vaccine. Methods. Humoral (IgG/IgM) (N- S-ELISpot) responses were studied 117 12 kidney-pancreas recipients at following time points: before first dose, 14 d second dose‚ third with median 203 232 start cycle, respectively. Results. After...
Wheat lipid transfer protein (LTP; Tri a 14) and ω5-gliadin have been described as major allergens in wheat allergy (WA) relevant wheat-induced anaphylaxis, frequently associated with cofactors.The objective of this study was to compare tools currently available routine diagnosis detect 14 sensitization, its clinical relevance, cosensitization other LTPs.One hundred eighteen adults sensitized rTri by ImmunoCAP® (cutoff ≥0.1 kUA/L) identified among 210 LTP allergic patients were included. We...
The global SARS-CoV-2 pandemic has highlighted the critical importance of evaluating adaptive immunological status in both infected individuals and those who have been vaccinated. While humoral immune response extensively studied, cellular component not progressed as rapidly due to challenges developing rapid diagnostic tests for activated T cells. This study introduces a rapid, user-friendly assay aimed at addressing this need by using early expression interferon-gamma (IFN-γ) transcripts...
The aim of the present study was to determine humoral and T-cell responses after four doses mRNA-1273 vaccine in solid organ transplant (SOT) recipients, predictors immunogenicity, including role previous SARS-CoV-2 infection immunity. Secondarily, safety also assessed. Liver, heart, kidney recipients eligible for vaccination from three different institutions Barcelona, Spain were included. IgM/IgG antibodies T cell ELISpot against S protein weeks receiving consecutive booster analyzed. One...
During the recent SARS-CoV-2 outbreak, there has been a recognized need of evaluating adaptative immunological status, not only in infected individuals, but also vaccinated population. While humoral immune response extensively assessed, cellular received less attention due to challenges transferring it into rapid diagnostic test. Consequently, is demand for development and user-friendly test detecting activated T cells. This study based on measuring interferon-gamma production as an indirect...
Abstract Background and Aims No data exists on humoral or cellular responses to mRNA vaccines in kidney transplant recipients (KTR) with HIV. We compared these HIV-positive negative KTR, as well people living HIV (PLWH) without transplantation. Method In a cross-sectional study of 33 patients receiving two (n=13) three (n=20) doses SARS-CoV-2 vaccination, we evaluated the response vaccination using Luminex platform for IgG IgM, assessed specific T cell S- N- protein by ELISpot. used logistic...
Enhancing our comprehension of mRNA vaccines may facilitate the future design novel aimed at augmenting immune protection while minimising reactogenic responses. Before this is carried out, it important to determine whether adaptive immunity correlates with reactogenicity profile vaccines. We studied a large cohort that was vaccinated answer question. This an observational study real-world data. Reactogenicity data were obtained from VigilVacCOVID study. Immunogenicity (humoral and cellular)...