A5045051271- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Prion Diseases and Protein Misfolding
- Alcoholism and Thiamine Deficiency
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Atrial Fibrillation Management and Outcomes
- Stroke Rehabilitation and Recovery
- Intracranial Aneurysms: Treatment and Complications
- Neurological Disease Mechanisms and Treatments
- Cardiac Imaging and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Neurological Disorders and Treatments
Hospital General de Granollers
2014-2025
Abstract The methionine (M)—valine (V) polymorphic codon 129 of the prion protein gene ( PRNP ) plays a central role in both susceptibility and phenotypic expression sporadic Creutzfeldt-Jakob diseases (sCJD). Experimental transmissions sCJD humanized transgenic mice led to isolation five strains, named M1, M2C, M2T, V2, V1, based on two major conformations pathological (PrP Sc , type 1 2), genotype determining propagation efficiency. While most frequent strains have been described...
Background: The release of neurotransmitters could promote neuroprotection and facilitate neuroplasticity. We evaluate in a randomized study the benefit levodopa serotonin stroke patients.Methods: SELEIS was unicenter, double-blind, randomized, placebo-controlled trial. Patients with first ischemic were randomly assigned between 0-5 days after onset four arms: 1) placebo, 2) citalopram 20 mg / day, 3) levodopa/carbidopa 100/25 day 4) plus mg/ for 6 months. primary outcome measure percentage...