A5005249975- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Nuclear Receptors and Signaling
- RNA regulation and disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Lysosomal Storage Disorders Research
- Botulinum Toxin and Related Neurological Disorders
- Ginkgo biloba and Cashew Applications
- Autism Spectrum Disorder Research
- Monoclonal and Polyclonal Antibodies Research
- Musculoskeletal pain and rehabilitation
- Cerebral Palsy and Movement Disorders
- Neuroscience and Neuropharmacology Research
- Cellular transport and secretion
- Peripheral Neuropathies and Disorders
- Vagus Nerve Stimulation Research
- Neurogenesis and neuroplasticity mechanisms
- Autoimmune Neurological Disorders and Treatments
- Restless Legs Syndrome Research
- Genetics and Neurodevelopmental Disorders
- Glycogen Storage Diseases and Myoclonus
- Psychosomatic Disorders and Their Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Genetic Neurodegenerative Diseases
- Alzheimer's disease research and treatments
Instituto de Biomedicina de Sevilla
2020-2025
Universidad de Sevilla
2020-2025
Hospital Universitario Virgen del Rocío
2020-2025
Biomedical Research Networking Center on Neurodegenerative Diseases
2021-2025
Instituto de Salud Carlos III
2022-2025
Centro de Investigación Biomédica en Red
2024-2025
Universitat Autònoma de Barcelona
2021
Consejo Superior de Investigaciones Científicas
2020-2021
Abstract Peripheral inflammatory immune responses are thought to play a major role in the pathogenesis of Parkinson’s disease (PD). The neutrophil-to-lymphocyte ratio (NLR), biomarker systemic inflammation, has been reported be higher patients with PD than healthy controls (HCs). present study was aimed at determining if peripheral response could influenced by genetic background PD. We included discovery cohort 222 (132 sporadic PD, 44 LRRK2 -associated (with p.G2019S and p.R1441G variants),...
ABSTRACT Background Peripheral inflammatory immune responses are suggested to play a major role in dopaminergic degeneration Parkinson's disease (PD). The neutrophil‐to‐lymphocyte ratio (NLR) is well‐established biomarker of systemic inflammation PD. Degeneration the nigrostriatal system can be assessed vivo using [ 123 I]FP‐CIT single photon emission computed tomography imaging striatal dopamine transporter (DAT) density. Objectives To assess relationship between peripheral profile (NLR,...
Imaging biomarkers bear great promise for improving the diagnosis and prognosis of cognitive impairment in Parkinson's disease (PD). We compared ability three commonly used neuroimaging modalities to detect cortical changes PD patients with mild (PD-MCI) dementia (PDD). 53 cognitively normal (PD-CN), 32 PD-MCI, 35 PDD underwent concurrent structural MRI (sMRI), diffusion-weighted (dMRI), [18F]FDG PET. extracted grey matter volumes mean diffusivity (MD, dMRI), standardized uptake value ratios...
<h3>Background and Objectives</h3> To study the clinical laboratory features of antineurofascin-155 (NF155)–positive autoimmune nodopathy (AN). <h3>Methods</h3> Patients with anti-NF155 antibodies detected on routine immunologic testing were included. Clinical characteristics, treatment response, functional scales (modified Rankin Scale [mRS] Inflammatory Rasch-built Overall Disability [I-RODS]) retrospectively collected at baseline follow-up. Autoantibody neurofilament light (NfL) chain...
Importance Functional movement disorders (FMDs) are frequent and disabling neurological with a substantial socioeconomic impact. Few randomized studies have analyzed the effectiveness of combined physiotherapy psychotherapy in patients’ quality life. Objective To assess efficacy multidisciplinary treatment (physiotherapy plus cognitive behavioral therapy) FMDs. Design, Setting, Participants This was parallel, rater-blinded, single-center, clinical trial. Recruitment took place from June 2022...
Deep brain stimulation (DBS) has emerged as an important therapeutic intervention for neurological and neuropsychiatric disorders. After initial programming, clinicians are tasked with fine-tuning DBS parameters through repeated in-person clinic visits. We aimed to evaluate whether patients achieve clinical benefit more rapidly by incorporating remote internet-based adjustment (RIBA) of into the continuum care. conducted a randomized controlled multicenter study (ClinicalTrails.gov...
Brain cholesterol metabolism has been described as altered in Parkinson's disease (PD) patients. Serum lipid levels have widely studied PD with controversial results among different populations and age groups. The present study is aimed at determining if the serum profile could be influenced by genetic background of We included 403 patients (342 sporadic patients, 30 GBA-associated 31 LRRK2-associated patients) 654 healthy controls (HCs). Total cholesterol, HDL, LDL, triglycerides were...
Previous studies suggest a link between CAG repeat number in the HTT gene and non-Huntington neurodegenerative diseases.The aim is to analyze whether expanded alleles and/or their size are associated with risk for developing α-synucleinopathies or behavior as modulators of phenotype.We genotyped APOE-Ɛ isoforms case-control series including patients either clinical neuropathological diagnosis α-synucleinopathy.We identified three Parkinson's disease (PD) (0.30%) two healthy controls (0.19%)...
Cognitive impairment is one of the most disabling nonmotor symptoms in Parkinson's disease (PD). Recently, a genome-wide association study Alzheimer's has identified PICALM rs3851179 polymorphism as significant susceptibility genes for after APOE. The aim this was to determine potential role and its genetic interaction with APOE development cognitive decline PD.A discovery cohort 712 patients PD were genotyped (rs3851179) (rs429358 rs7412) polymorphisms. APOE-PICALM dysfunction studied using...
Impulse control disorders (ICDs) are frequent in Parkinson's disease (PD), with associated clinical and genetic risk factors. This study was aimed at analyzing the features background that underlie ICDs PD.We included 353 patients PD this (58.9% men, mean age 62.4 ± 10.58 years, onset 52.71 11.94 years). We used validated Questionnaire for Impulsive-Compulsive Disorders Disease screening. Motor, nonmotor, treatment-related were evaluated according to presence of ICDs. Twenty-one variants...
Purpose To determine whether the development of levodopa-induced dyskinesia (LID) in Parkinson disease (PD) specifically relates to dopaminergic depletion sensorimotor-related subregions striatum. Methods Our primary study sample consisted 185 locally recruited PD patients, which 73 (40%) developed LID. Retrospective 123 I-FP-CIT SPECT data were used quantify specific dopamine transporter (DAT) binding ratio within distinct functionally defined striatal related limbic, executive, and...
Abstract We conducted the largest PSP GWAS of Iberian population to date (522 cases from 22 Spanish and Portuguese institutions). independently replicated seven known risk variants, unveiled a novel locus in NFASC/CNTN2 after meta-analysing our results with newly available Dutch cohort publicly summary statistics. These findings highlight importance neuron-oligodendrocyte interactions etiopathology.
Abstract Background and purpose Parkinson disease (PD) is a complex heterogeneous neurodegenerative disorder with broad spectrum of clinical manifestations, determined by interplay environmental genetic factors. This study aimed to investigate variants associated PD assess their impact on the phenotype through genotype–phenotype correlations. Methods We employed targeted resequencing panel analyze 27 genes linked in cohort 1185 patients from southern Spain. Variants were categorized based...
Abstract Background Co‐morbid Alzheimer’s disease (AD) pathology is a major risk factor for cognitive impairment (CI) in PD, but whether and how AD co‐pathology affects the clinical phenotype of PD‐CI incompletely understood. Recently validated plasma biomarkers pathology, such as ptau217, hold great promise to revolutionize diagnosis neurodegenerative diseases. Here, we used ptau217 detect well‐characterized cohort PD patients with CI examine its associations APOE4 genotype, profile,...
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