A5079974618- Neurological disorders and treatments
- Transcranial Magnetic Stimulation Studies
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neural Engineering
- Genetic Neurodegenerative Diseases
- Motor Control and Adaptation
- Muscle activation and electromyography studies
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Vagus Nerve Stimulation Research
- Botulinum Toxin and Related Neurological Disorders
- Autism Spectrum Disorder Research
- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- Stroke Rehabilitation and Recovery
- Photoreceptor and optogenetics research
- Nerve injury and regeneration
- Cardiac pacing and defibrillation studies
- Spatial Neglect and Hemispheric Dysfunction
- Vestibular and auditory disorders
- Neuroscience and Neuropharmacology Research
- Mitochondrial Function and Pathology
- Hemispheric Asymmetry in Neuroscience
- Action Observation and Synchronization
- Advanced Neuroimaging Techniques and Applications
International Neuromodulation Society
2019-2025
Abbott (United States)
2019-2025
Abbott (United Kingdom)
2024
Abbott (Canada)
2020-2022
Abbott Fund
2021
Abbott (Sweden)
2021
University of Oxford
2012-2019
London Clinic
2017-2019
Plano Cancer Institute
2019
John Radcliffe Hospital
2010-2018
The brain-derived neurotrophic factor gene (BDNF) is one of many genes thought to influence synaptic plasticity in the adult brain and shows a common single nucleotide polymorphism (BDNF Val66Met) normal population that associated with differences hippocampal volume episodic memory. It also possible changes motor cortex following simple learning task. Here we extend these studies by using new non-invasive transcranial magnetic stimulation (TMS) direct current (TDCS) techniques directly test...
<h3>Introduction & objectives</h3> Adaptive deep brain stimulation (aDBS) uses feedback from signals to guide stimulation. A recent acute trial of unilateral aDBS showed that can lead substantial improvements in contralateral hemibody Unified Parkinson’s Disease Rating Scale (UPDRS) motor scores and may be superior conventional continuous DBS disease (PD). We test whether potential benefits are retained with bilateral the face concurrent medication. <h3>Methods</h3> applied 4 patients PD...
See Moll and Engel (doi:10.1093/aww308) for a scientific commentary on this article. Brain regions dynamically engage disengage with one another to execute everyday actions from movement decision making. Pathologies such as Parkinson’s disease tremor emerge when brain controlling cannot readily decouple, compromising motor function. Here, we propose novel stimulation strategy that selectively regulates neural synchrony through phase-specific stimulation. We demonstrate the first time...
The left dorsal premotor cortex (PMd) is thought to play a dominant role in the selection of movements made by either hand. We used transcranial magnetic stimulation study functional connectivity PMd and right primary motor (M1) during an acoustic choice reaction time (RT) task involving contraction thumb forefinger. facilitatory inhibitory pathways that can be demonstrated between M1 at rest were suppressed most period. However, they activated briefly start period, depending on whether cue...
Hemispatial neglect is common after unilateral brain damage, particularly to perisylvian structures in the right-hemisphere (RH). In this disabling syndrome, behaviour and awareness are biased away from contralesional side of space towards ipsilesional side. Theoretical accounts terms hemispheric rivalry have speculated that intact left-hemisphere (LH) may become hyper-excitable a RH lesion, due release inhibition damaged hemisphere. We tested directly using novel twin-coil transcranial...
Paired-pulse transcranial magnetic stimulation (TMS) has been applied as a probe to test functional connectivity within distinct cortical areas of the human motor system. Here, we tested interaction between posterior parietal cortex (PPC) and ipsilateral (M1). A conditioning TMS pulse over right PPC potentiates evoked-potentials evoked by cortex, with time course characterized two phases: an early peak at 4 ms interstimulus interval (ISI) late 15 ISI. Activation this facilitatory pathway...
Several studies have suggested that the cerebellum has an important role in timing of subsecond intervals. Previous using transcranial magnetic stimulation (TMS) to test this hypothesis directly produced inconsistent results. Here we used 1-Hz repetitive TMS (rTMS) for 10 min over right or left cerebellar hemisphere interfere transiently with processing assess its effect on performance a finger-tapping task. Subjects tapped their index finger 1 (synchronization phase) auditory visual cue at...
Levodopa induced dyskinesias (LID) are a common problem which ultimately limit the effective treatment of patients with Parkinson's disease (PD). There is accumulating evidence that LID develop due to abnormal synaptic plasticity, in turn influenced by release brain derived neurotrophic factor (BDNF).The influence functional polymorphism BDNF gene on risk developing large cohort PD (n = 315), who were independently and variably treated levodopa and/or other dopaminergic treatments, was...
Background. Noninvasive cortical stimulation could represent an add-on treatment to enhance motor recovery after stroke. However, its clinical value, including anticipated size and duration of the effects, remains largely unknown. Objective. The authors designed a small semi-randomized trial explore whether long-lasting clinically important gains can be achieved by adding theta burst (TBS), form repetitive transcranial magnetic (TMS), rehabilitation program for hand. Methods. A total 41...
Optimal decision-making requires balancing fast but error-prone and more accurate slower decisions through adjustments of decision thresholds. Here, we demonstrate two distinct correlates such speed-accuracy by recording subthalamic nucleus (STN) activity electroencephalography in 11 Parkinson’s disease patients during a perceptual task; STN low-frequency oscillatory (LFO) (2–8 Hz), coupled to at prefrontal electrode Fz, beta (13–30 Hz) electrodes C3/C4 close motor cortex. These differed not...
To optimally balance opposing demands of speed and accuracy during decision-making, we must flexibly adapt how much evidence require before making a choice. Such adjustments in decision thresholds have been linked to the subthalamic nucleus (STN), therapeutic STN deep-brain stimulation (DBS) has shown interfere with this function. Here, performed continuous as well closed-loop DBS while Parkinson's disease patients perceptual decision-making task. Closed-loop allowed temporally patterned...
We estimate that 208,000 deep brain stimulation (DBS) devices have been implanted to address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters pooled data determined expanded in its scope has applied multiple an effort modulate neural circuitry. The was founded 2012 providing a space where clinicians, engineers, researchers from industry academia discuss current emerging technologies logistical ethical issues facing the field. emphasis is on cutting edge...
Posterior parietal cortex (PPC) has connections with motor and premotor cortex, thought to transfer information relevant for planning movements in space. We used twin-coil transcranial magnetic stimulation (tcTMS) methods show that the functional interplay between human right PPC ipsilateral (M1) varies current plans. tcTMS during reaction time of a reach task revealed facilitatory influences on M1 only when (contralateral) leftward rather than rightward reach, at two specific intervals (50...
Tremor is a cardinal feature of Parkinson's disease and essential tremor, the two most common movement disorders. Yet, mechanisms underlying tremor generation remain largely unknown. We hypothesized that driving deep brain stimulation electrodes at frequency closely matching patient's own should interact with neural activity responsible for effect on reveal role different targets in generation. Moreover, responses to might pathophysiological differences between parkinsonian circuits....
Intermittent theta burst stimulation (iTBS) transiently increases motor cortex excitability in healthy humans by a process thought to involve synaptic long-term potentiation (LTP), and this is enhanced nicotine. Acquisition of ballistic task likewise accompanied increased presumed intracortical LTP. Here, we test how iTBS nicotine influences subsequent learning. Ten subjects participated double-blinded placebo-controlled trial testing the effects alone rate learning but increase was blocked...