A5060213295- Transcranial Magnetic Stimulation Studies
- Neurological disorders and treatments
- Muscle activation and electromyography studies
- Stroke Rehabilitation and Recovery
- Vestibular and auditory disorders
- Neuroscience and Neural Engineering
- Functional Brain Connectivity Studies
- Motor Control and Adaptation
- Intraoperative Neuromonitoring and Anesthetic Effects
- EEG and Brain-Computer Interfaces
- Amyotrophic Lateral Sclerosis Research
- Advanced Neuroimaging Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Spinal Cord Injury Research
- Pain Management and Treatment
- Neural dynamics and brain function
- Protein Tyrosine Phosphatases
- Nerve injury and regeneration
- Neurogenetic and Muscular Disorders Research
- Acute Ischemic Stroke Management
- Advanced MRI Techniques and Applications
- Emergency and Acute Care Studies
- Neuroscience and Neuropharmacology Research
- Neural and Behavioral Psychology Studies
- Cholinesterase and Neurodegenerative Diseases
Servicio de Salud de Castilla La Mancha
2004-2024
University of Castilla-La Mancha
2021-2024
Hospital General Nuestra Señora del Prado
2023-2024
University Hospital HM Puerta del Sur
2015-2022
Hospital Virgen del Puerto
2022
HM Hospitales
2016-2022
Universidad San Pablo CEU
2016-2020
Hospital Nacional de Parapléjicos
2004-2018
Biomedical Research Networking Center on Neurodegenerative Diseases
2017
Ospedale San Bortolo
2013-2015
Previous studies have shown that low-frequency repetitive transcranial magnetic stimulation (rTMS) suppresses motor-evoked potentials (MEPs) evoked by single pulse TMS. The aim of the present paper was to investigate central nervous system level at which rTMS produces a suppression MEP amplitude. We recorded corticospinal volleys TMS motor cortex before and after 1 Hz in five conscious subjects who had an electrode implanted cervical epidural space for control pain. One patients Parkinson's...
Theta burst stimulation (TBS) is a form of repetitive transcranial magnetic (TMS). When applied to motor cortex it leads after-effects on corticospinal and corticocortical excitability that may reflect LTP/LTD-like synaptic effects. An inhibitory TBS (continuous, cTBS) suppresses MEPs, spinal epidural recordings show this due suppression the I1 volley evoked by TMS. Here we investigate whether excitatory (intermittent, iTBS) affects same I-wave circuitry. We recorded volleys single pulse TMS...
Repetitive transcranial magnetic stimulation (rTMS) of human motor cortex can produce long-lasting changes in the excitability excitatory and inhibitory neuronal networks. The effects rTMS depend critically on stimulus frequency. aim our present study was to compare different protocols. We compared aftereffects 6 protocols [paired associative at interstimulus intervals 25 (PAS(25)) 10 ms (PAS(10)); theta burst delivered as continuous (cTBS) or intermittent delivery pattern (iTBS); 1- 5-Hz...
Subanaesthetic doses of the N-methyl-D-aspartate (NMDA) antagonist ketamine have been shown to determine a dual modulating effect on glutamatergic transmission in experimental animals, blocking NMDA receptor activity and enhancing non-NMDA through an increase release endogenous glutamate. Little is known about effects excitability human central nervous system. The subanaesthetic, graded incremental (0.01, 0.02 0.04 mg kg-1 min-1, I.V.) cortical networks motor cortex were examined with range...
Experimental studies have demonstrated that the GABAergic system modulates acetylcholine release and, through GABA(A) receptors, tonically inhibits cholinergic activity. Little is known about effects of GABA on activity in human central nervous system. In vivo evaluation some circuits brain has recently been introduced using a transcranial magnetic stimulation (TMS) protocol based coupling peripheral nerve with TMS motor cortex. Peripheral inputs an inhibitory effect cortex excitability at...
Transcranial direct current stimulation (tDCS) can produce a lasting polarity-specific modulation of cortical excitability in the brain, and it is increasingly used experimental clinical settings. Recent studies suggest that after-effects tDCS are related to molecular mechanisms activity-dependent synaptic plasticity. Here we investigated effect DCS on induction one most studied N-methyl-d-aspartate receptor-dependent forms long-term potentiation (LTP) activity at CA3-CA1 synapses...
Inhibition is of fundamental importance to regulate activity in cortical circuits. mediated through a diversity different interneurones and gamma-aminobutyric acid A receptor (GABA(A)R) subtypes. Here we employed paired-pulse transcranial magnetic stimulation (TMS) measure short interval intracortical inhibition (SICI), GABA(A)R-mediated human motor cortex, address the question which GABA(A)R subtype responsible for this form inhibition. It has been shown that classical benzodiazepines...
A magnetic transcranial conditioning stimulus given over the motor cortex at intensities below active threshold for obtaining motor-evoked potentials (MEPs) facilitates EMG responses evoked rest in hand muscles by a suprathreshold 10-25 ms later. This is known as intracortical facilitation (ICF). We recorded descending volleys produced single and paired stimulation through high cervical epidural electrodes implanted pain relief six conscious patients. At interstimulus intervals (ISIs) of 10...
Peripheral nerve inputs have an inhibitory effect on motor cortex excitability at short intervals (short‐latency afferent inhibition, SAI). This can be tested by coupling electrical stimulation of peripheral with transcranial magnetic (TMS) the cortex. SAI is reduced anticholinergic drug scopolamine, and in patients Alzheimer's disease. Therefore, it possible that a marker central cholinergic activity important for memory function. The benzodiazepine lorazepam also reduces SAI. Since...
<b>Background:</b> In vivo evaluation of cholinergic circuits the human brain has recently been introduced using a transcranial magnetic stimulation (TMS) protocol based on coupling peripheral nerve with motor cortex TMS (short latency afferent inhibition, SAI). SAI is reduced in Alzheimer’s disease (AD) and drugs enhancing transmission increase SAI. <b>Methods:</b> We evaluated whether testing, together test-retest, after single dose acetylcholinesterase (AChE) inhibitor rivastigmine, might...
Repetitive transcranial magnetic stimulation of the brain given as intermittent theta burst (iTBS) can induce long-term potentiation (LTP)–like changes in stimulated hemisphere and depression (LTD)–like opposite hemisphere. We evaluated whether LTP- LTD-like produced by iTBS acute stroke correlate with outcome at 6 months. excitability affected (AH) unaffected (UH) measuring motor threshold motor-evoked potential (MEP) amplitude under baseline conditions after AH 17 patients ischemic stroke....
Background. Noninvasive cortical stimulation could represent an add-on treatment to enhance motor recovery after stroke. However, its clinical value, including anticipated size and duration of the effects, remains largely unknown. Objective. The authors designed a small semi-randomized trial explore whether long-lasting clinically important gains can be achieved by adding theta burst (TBS), form repetitive transcranial magnetic (TMS), rehabilitation program for hand. Methods. A total 41...
The test of short latency afferent inhibition (SAI) the motor cortex is helpful in demonstrating dysfunction central cholinergic circuits Alzheimer disease (AD). authors evaluated SAI 20 patients with frontotemporal dementia (FTD) and compared data those from AD controls. was normal FTD, whereas it reduced AD. may represent an additional tool to discriminate FTD
In Parkinson's disease, striatal dopamine depletion produces profound alterations in the neural activity of cortico-basal ganglia motor loop, leading to dysfunctional output and parkinsonism. A key regulator is balance between excitation inhibition primary cortex, which can be assessed humans with transcranial magnetic stimulation techniques. Despite decades research, functional state cortical disease remains uncertain. Towards resolving this issue, we applied paired-pulse protocols 166...