A5087264780- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Transcranial Magnetic Stimulation Studies
- Neural dynamics and brain function
- Epilepsy research and treatment
- Advanced MRI Techniques and Applications
- Stroke Rehabilitation and Recovery
- Neurological disorders and treatments
- Optical Imaging and Spectroscopy Techniques
- Muscle activation and electromyography studies
- Botulinum Toxin and Related Neurological Disorders
- Neuroscience and Neuropharmacology Research
- Non-Invasive Vital Sign Monitoring
- Pharmacological Effects and Toxicity Studies
- Neural and Behavioral Psychology Studies
- Motor Control and Adaptation
- Vestibular and auditory disorders
- Neuroscience and Neural Engineering
- Photoacoustic and Ultrasonic Imaging
- Advanced Neuroimaging Techniques and Applications
- Neural Networks and Applications
- Electromagnetic Fields and Biological Effects
- Vagus Nerve Stimulation Research
- Heart Rate Variability and Autonomic Control
- Noise Effects and Management
Western University
2022-2025
IRCCS San Camillo Hospital
2016-2023
Montreal Neurological Institute and Hospital
2015-2022
McGill University
2015-2022
University of Padua
2019-2022
University of Genoa
2022
Ospedale generale di zona San Camillo Treviso
2016-2020
Copenhagen University Hospital
2015-2018
Hvidovre Hospital
2013-2018
Ospedale Civile di Venezia
2017-2018
The efficacy of standard rehabilitative therapy for improving upper limb functions after stroke is limited; thus, alternative strategies are needed. Vagus nerve stimulation (VNS) paired with rehabilitation a promising approach, but the invasiveness this technique limits its clinical application. Recently, noninvasive method to stimulate vagus has been developed. aim present study was explore whether VNS combined robotic can enhance functionality in chronic stroke. Safety and combination have...
Introduction: Surgical treatment of drug-resistant epilepsy relies on the identification seizure onset zone (SOZ) and often requires intracranial EEG (iEEG).We have developed a new approach for non-invasive magnetic electric source imaging SOZ (MSI-SOZ ESI-SOZ) from ictal magnetoencephalography (MEG) recordings, using wavelet-based Maximum Entropy Mean (wMEM) method.We compared performance MSI-SOZ ESI-SOZ with interictal spike localization (MSI-spikes ESI-spikes) clinical (i.e., based iEEG...
BackgroundCortical excitability measures neural reactivity to stimuli, usually delivered via Transcranial Magnetic Stimulation (TMS). Excitation/inhibition balance (E/I) is the ongoing equilibrium between excitatory and inhibitory activity of circuits. According some studies, E/I could be estimated in-vivo non-invasively through modeling electroencephalography (EEG) signals termed 'intrinsic excitability' measures. Several have been proposed (phase consistency in gamma band, sample entropy,...
Purpose: In the chronic phase of stroke brain plasticity plays a crucial role for further motor control improvements. This study aims to assess plastic reorganizations and their association with clinical progresses induced by robot-aided
We present a framework to detect fast oscillations (FOs) in magnetoencephalography (MEG) and perform magnetic source imaging (MSI) determine the location extent of their generators cortex. FOs can be physiologic origin associated sensory processing memory consolidation. In epilepsy, are pathologic biomarkers epileptogenic zone. Seventeen patients with focal epilepsy previously confirmed identified scalp electroencephalography (EEG) were evaluated. To handle data deriving from large number...
Source localization of interictal epileptic discharges (IEDs) is clinically useful in the presurgical workup epilepsy patients. It usually obtained by equivalent current dipole (ECD) which localizes a point source and only inverse solution approved clinical guidelines. In contrast, magnetic imaging using distributed methods (dMSI) provides maps location extent generators, but its yield has not been validated. We systematically compared ECD versus dMSI performed coherent Maximum Entropy on...
Remembering to execute delayed intentions (i.e., prospective memory, PM) entails the allocation of internal and external attention. These processes are crucial for rehearsing PM in memory monitoring presence cue environment, respectively. The study took advantage excellent spatial temporal resolution magnetoencephalography (MEG) delineate neural mechanisms underlying PM. spatio-temporal dynamic theta alpha oscillations were explored 21 participants two tasks compared a baseline condition...
Patients with epilepsy are characterized by a dysregulation of excitation/inhibition balance (E/I). The assessment E/I may inform clinicians during the diagnosis and therapy management, even though it is rarely performed. An accessible measure brain represents clinically relevant feature. Here, we exploited exponent aperiodic component power spectrum electroencephalography (EEG) signal, as non-invasive cost-effective proxy balance. We recorded resting-state activity high-density EEG from 67...
We aimed at studying the hemodynamic response (HR) to Interictal Epileptic Discharges (IEDs) using patient-specific and prolonged simultaneous ElectroEncephaloGraphy (EEG) functional Near InfraRed Spectroscopy (fNIRS) recordings. The epileptic generator was localized Magnetoencephalography source imaging. fNIRS montage tailored for each patient, an algorithm optimize sensitivity generator. Optodes were glued collodion achieve acquisition with high quality signal. data analysis handled no a...
Introduction. We aimed to test differences between healthy subjects and patients with respect slow wave activity during wakefulness sleep. Methods. Fifteen affected by nonlesional focal epilepsy originating within temporal areas fourteen matched controls underwent a 24-hour EEG recording. studied the power spectral density sleep in delta (1-4 Hz), theta (5-7 alpha (8-11 sigma (12-15 beta (16-20 Hz) bands. Results. During sleep, showed higher from frequency bands compared controls. The effect...
Focal epilepsy is a disorder affecting several brain networks; however, surgery usually targets restricted region, the so-called epileptic focus. There growing interest in embedding resting state (RS) connectivity analysis into pre-surgical workup.In this retrospective study, we analyzed Magnetoencephalography (MEG) long-range RS functional patterns patients with drug-resistant focal epilepsy. MEG recorded prior to from seven seizure-free (Engel Ia) and five non III or IV) were (minimum...
Abstract Source localization of interictal epileptiform discharges (IEDs) is clinically useful in the presurgical workup epilepsy patients. We aimed to compare performance four different distributed magnetic source imaging (dMSI) approaches: Minimum norm estimate (MNE), dynamic statistical parametric mapping (dSPM), standardized low‐resolution electromagnetic tomography (sLORETA), and coherent maximum entropy on mean (cMEM). also evaluated whether a simple average maps obtained from multiple...
During the past decades there has been an increasing interest in tracking brain network fluctuations health and disease by means of resting state functional magnetic resonance imaging (rs-fMRI). Rs-fMRI however does not provide ideal environmental setting, as participants are continuously exposed to noise generated MRI coils during acquisition Echo Planar Imaging (EPI). We investigated effect EPI on activity connectivity using magnetoencephalography (MEG), reproducing acoustic...
Introduction Eslicarbazepine acetate (ESL) is an antiepileptic drug approved as monotherapy or add-on for the treatment of epilepsy with seizures focal onset. ESL owns a good profile in terms efficacy and tolerability, but its effects on EEG activity connectivity are unknown. The purpose this study was to investigate changes after persons (PFE). Material Methods We performed multicentre, longitudinal, retrospective, quantitative population 22 PFE control group 40 controls. investigated...
Abstract Fusion of electroencephalography (EEG) and magnetoencephalography (MEG) data using maximum entropy on the mean method (MEM‐fusion) takes advantage complementarities between EEG MEG to improve localization accuracy. Simulation studies demonstrated MEM‐fusion be robust especially in noisy conditions such as single spike source localizations (SSSL). Our objective was assess reliability SSSL clinical data. We proposed cluster results find most reliable consistent map from reconstructed...
Abstract Transcranial direct current stimulation (tDCS) is a noninvasive brain technique able to induce plasticity phenomena. Although tDCS application has been spreading over variety of neuroscience domains, the mechanisms by which acts are largely unknown. We investigated effects on cortical gamma synchrony, crucial player in function. performed randomized, sham‐controlled, double‐blind study healthy subjects, combining and magnetoencephalography. By driving activity via 40 Hz auditory...