A5043446531- Alzheimer's disease research and treatments
- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Dementia and Cognitive Impairment Research
- Nanoparticle-Based Drug Delivery
- Neuroinflammation and Neurodegeneration Mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Genetic Associations and Epidemiology
- Tryptophan and brain disorders
- RNA Interference and Gene Delivery
- Advanced Proteomics Techniques and Applications
- Tea Polyphenols and Effects
- Glaucoma and retinal disorders
- Bioinformatics and Genomic Networks
- Diet and metabolism studies
- Graphene and Nanomaterials Applications
- Bee Products Chemical Analysis
- Dermatology and Skin Diseases
- Natural Antidiabetic Agents Studies
- Extracellular vesicles in disease
- Biochemical effects in animals
- Retinal Imaging and Analysis
- Ocular Surface and Contact Lens
- Mitochondrial Function and Pathology
- Computational Drug Discovery Methods
Universitat Internacional de Catalunya
2021-2025
Biomedical Research Networking Center on Neurodegenerative Diseases
2018-2025
Instituto de Salud Carlos III
2019-2025
Fundació ACE
2021-2025
Universitat de Barcelona
2016-2024
Emory University
2024
University of Iceland
2024
Icelandic Heart Association
2024
Alzheimer’s Disease Neuroimaging Initiative
2024
Novartis (Switzerland)
2024
Epigallocatechin-3-gallate (EGCG) is a candidate for treatment of Alzheimer's disease (AD) but its inherent instability limits bioavailability and effectiveness. We found that EGCG displayed increased stability when formulated as dual-drug loaded PEGylated PLGA nanoparticles (EGCG/AA NPs). Oral administration EGCG/AA NPs in mice resulted accumulation all major organs, including the brain. Pharmacokinetic comparison plasma brain following oral free or showed that, whilst both cases initial...
Memantine, drug approved for moderate to severe Alzheimer's disease, has not shown be fully effective. In order solve this issue, polylactic-co-glycolic (PLGA) nanoparticles could a suitable solution increase drug's action on the target site as well decrease adverse effects. For these reason, Memantine was loaded in biodegradable PLGA nanoparticles, produced by double emulsion method and surface-coated with polyethylene glycol. MEM–PEG–PLGA (NPs) were aimed blood–brain barrier (BBB) upon...
Effective intervention is essential to combat the coming epidemic of neurodegenerative (ND) diseases. Nanomedicine can overcome restrictions CNS delivery imposed by blood–brain barrier, and thus be instrumental in preclinical discovery therapeutic ND Polymeric nanoparticles (PNPs) have shown great potential versatility encapsulate several compounds simultaneously controlled drug-delivery systems target them deepest brain regions. Here, we critically review recent advances development drugs...
Accessible and cost-effective diagnostic tools are urgently needed to accurately quantify blood biomarkers support early diagnosis of Alzheimer's disease (AD). In this study, we investigated the ability plasma amyloid-beta (Aβ)42/Aβ40 ratio measured by an antibody-free mass-spectrometric (MS) method, ABtest-MS, detect pathological changes AD.This cohort study included data from baseline 2-year follow-up visits Fundació ACE Healthy Brain Initiative (FACEHBI) study. Plasma Aβ42/Aβ40 was with...
A deeper understanding of the molecular processes underlying late-onset Alzheimer's disease (LOAD) could aid in biomarker and drug target discovery. Using high-throughput serum proteomics prospective population-based Age, Gene/Environment Susceptibility-Reykjavik Study (AGES) cohort 5,127 older Icelandic adults (mean age, 76.6 ± 5.6 years), we identified 303 proteins associated with incident LOAD over a median follow-up 12.8 years. Over 40% these were independently APOE-ε4 carrier status,...
Abstract Background Advancement in screening tools accessible to the general population for early detection of Alzheimer’s disease (AD) and prediction its progression is essential achieving timely therapeutic interventions conducting decentralized clinical trials. This study delves into application Machine Learning (ML) techniques by leveraging paralinguistic features extracted directly from a brief spontaneous speech (SS) protocol. We aimed explore capability ML discriminate between...
Abstract Inflammation plays a key role in the development of neurodegenerative disorders that are currently incurable. Licochalcone A (LCA) has been described as an emerging anti-inflammatory drug with multiple therapeutical properties could potentially prevent neurodegeneration. However, its neuroprotective mechanism remains unclear. Here, we investigated if LCA prevents cognitive decline induced by Lipopolysaccharide (LPS) and elucidated potential benefits. For that, 8-week-old C57BL6/J...
Ocular inflammation is one of the most prevalent diseases in ophthalmology, which can affect various parts eye or surrounding tissues. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, are commonly used to treat ocular form eye-drops. However, their bioavailability tissues very low (less than 5%). Therefore, drug delivery systems biodegradable polymeric PLGA nanoparticles constitute a suitable alternative topical administration, they improve and simultaneously reduce induced...