A5011388276- Lipid Membrane Structure and Behavior
- Hepatitis C virus research
- Influenza Virus Research Studies
- HIV Research and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Antimicrobial Peptides and Activities
- Antibiotic Resistance in Bacteria
- Chemotherapy-induced organ toxicity mitigation
- Monoclonal and Polyclonal Antibodies Research
- RNA Interference and Gene Delivery
- Hepatitis B Virus Studies
- Antibiotics Pharmacokinetics and Efficacy
- Analytical Methods in Pharmaceuticals
- Viral gastroenteritis research and epidemiology
- Advanced Drug Delivery Systems
- Safe Handling of Antineoplastic Drugs
- Advancements in Transdermal Drug Delivery
- Nanoparticle-Based Drug Delivery
- Analytical Chemistry and Chromatography
- Pneumonia and Respiratory Infections
- Ocular Surface and Contact Lens
- Historical Studies on Spain
- Nosocomial Infections in ICU
- DNA and Nucleic Acid Chemistry
- Historical Art and Architecture Studies
Institut de Nanociència i Nanotecnologia de la Universitat de Barcelona
2014-2024
Universitat de Barcelona
2012-2024
Deleted Institution
2024
Complejo Hospitalario de Navarra
2024
Hospital Universitari de Santa Maria
2008-2024
Biomedical Research Institute of Lleida
2024
State Research Institute of Organic Chemistry and Technology
2021
Kyoto University
2021
Dalian University of Technology
2021
Henan Normal University
2021
Most Gram-negative bacteria are susceptible to polymyxin B (PxB), and development of resistance this cationic lipopeptide is very rare. PxB mechanism action involves interaction with both the outer membrane (OM) inner (IM) bacteria. For design new antibiotics based on structure improved therapeutic indexes, it essential establish key features that important for activity. We have used an approach mimicking layers OM IM using monolayers lipopolysaccharide (LPS) or anionic...
Ocular inflammation is one of the most prevalent diseases in ophthalmology, which can affect various parts eye or surrounding tissues. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, are commonly used to treat ocular form eye-drops. However, their bioavailability tissues very low (less than 5%). Therefore, drug delivery systems biodegradable polymeric PLGA nanoparticles constitute a suitable alternative topical administration, they improve and simultaneously reduce induced...
Nanocarriers, and especially nanostructured lipid carriers (NLC), represent one of the most effective systems for topical drug administration. NLCs are biodegradable, biocompatible provide a prolonged release. The glutamate release inhibitor Riluzole (RLZ) is currently used amyotrophic lateral sclerosis (ALS), with anti-proliferative effects potentially beneficial diseases excessive cell turnover. However, RLZ possesses low water solubility high light-sensibility. We present here optimized...
Introduction Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Current core cerebrospinal fluid (CSF) AD biomarkers, widely employed for diagnosis, require lumbar puncture to be performed, making them impractical as screening tools. Considering the role of sleep disturbances in AD, recent research suggests quantitative electroencephalography features potential non-invasive biomarkers pathology. However, analysis comprehensive polysomnography (PSG) signals remains...
Recent evidence indicates a link between Parkinson's Disease (PD) and the expression of a-synuclein (SNCA) isoforms with different 3' untranslated regions (3'UTRs). Yet, post-transcriptional mechanisms regulating SNCA are unknown. Using large-scale in vitro /in silico screening we identified RNA-binding proteins (RBPs) that interact UTRs. We two RBPs, ELAVL1 TIAR, bind high affinity to most abundant translationally active UTR isoform (575 nt). Knockdown overexpression experiments indicate...
Abstract The heterogeneous photocatalytic oxidation of phenol in aqueous diluted solutions over TiO 2 particles under UV‐illumination has been investigated. It observed that the yield photooxidation depends strongly on pH solution. Maximum yields are obtained at 8 and also very alkaline media. These results explained considering processes take place surface semiconductor, which OH radicals have an important role. With respect to initial charge transfer steps a kinetic analysis performed....
E1(145−162), a peptide corresponding to the structural protein E1 of GB virus C, has been shown earlier bind at pH 7.4 vesicles containing 1,2-dimyiristoyl-sn-glycero-3-phospho-rac-(1-glycerol)] (DMPG) and 1,2-dimyiristoyl-sn-glycero-3-phosphocholine (DMPC) phospholipids. To deepen understanding interaction E1(145−162) with lipid membrane, in this paper, we report detailed study surface properties peptide, miscibility properties, behavior mixed monomolecular films it three phospholipids...
Abstract The dramatically increased frequency of antibiotic resistance has led to intensive efforts towards developing new families antibiotics. Membrane‐active peptides such as polymyxin B (PxB) hold promise the next generation antibiotics, since they rarely spur evolution resistance. At low concentrations in membrane, PxB forms vesicle–vesicle contacts and induces lipid exchange without leakage or fusion, a phenomenon that can explain its specificity Gram‐negative bacteria by contact...
Abstract Five peptide sequences corresponding to the E1 protein of GBV‐C [NCCAPEDIGFCLEGGCLV (P7), APEDIGFCLEGGCLVALG (P8), FCLEGGCLVALGCTICTD (P10), QAGLAVRPGKSAAQLVGE (P18), and AQLVGELGSLYGPLSVSA (P22)] were synthesized because they capable interfering with HIV‐1 fusion (HIV‐1 FP)–vesicle interaction. In this work interaction these peptides FP, as well membrane models, was analyzed corroborate their inhibition ability understand if takes place in solution or at level. Several studies...
Hepatitis A virus (HAV) is composed mainly of three structural capsid proteins: VP1, VP2 and VP3. Our group has reported the synthesis immunogenic evaluation VP3 (110-121) peptide sequence. In present work, in order to stimulate a T-cell immune response, we have selected HAV-VP3 (102-121) which maximum amphipathicity. Its was carried out manually solid phase semipreparative HPLC used for purification crude peptide. Finally purified characterized by analytical HPLC, amino acid analysis MS....
Fragile X syndrome is the most common form of hereditary mental retardation. The molecular basis this mainly a CGG expansion in 5' untranslated region FMR1 gene. Expansions with more than 200 repeats abolish gene expression causing classical fragile phenotype. Premutation carriers (55-200 CGG) have normal cognitive function increased risk developing premature ovarian failure and X-associated tremor-ataxia (FXTAS). Some clinical features associated FXTAS, such as tremor, gait ataxia, decline,...
Acute ischemic stroke is a leading cause of pediatric death and disability. A clinical scale adapted for children can ensure early detection candidates urgent acute treatment. The Rapid Arterial Occlusion Evaluation (RACE) adults, which scores 5 items (facial palsy 0-2; arm motor function leg head/gaze deviation 0-1; aphasia or agnosia 0-2), has good sensitivity specificity in detecting large vessel occlusion.