A5002959957- Essential Oils and Antimicrobial Activity
- Natural Compound Pharmacology Studies
- Phytochemistry and Biological Activities
- Bioactive Compounds and Antitumor Agents
- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Natural product bioactivities and synthesis
- Nanoparticles: synthesis and applications
- Phytochemicals and Antioxidant Activities
- Antimicrobial Peptides and Activities
- Carbohydrate Chemistry and Synthesis
- Salmonella and Campylobacter epidemiology
- Wound Healing and Treatments
- Bacteriophages and microbial interactions
- Phytochemistry and Bioactivity Studies
- Phytochemical compounds biological activities
- Escherichia coli research studies
- Antimicrobial Resistance in Staphylococcus
- Plant Pathogenic Bacteria Studies
- Biological Activity of Diterpenoids and Biflavonoids
- Biochemical and Structural Characterization
- Traditional and Medicinal Uses of Annonaceae
- Bioactive natural compounds
- Listeria monocytogenes in Food Safety
- Piperaceae Chemical and Biological Studies
Prince of Songkla University
2016-2025
Rajamangala University of Technology Srivijaya
2019
Ramkhamhaeng University
2010
UNSW Sydney
2004
Due to their abilities form strong biofilms, Staphylococcus aureus and epidermidis are the most frequently isolated pathogens in persistent chronic implant-associated infections. As biofilm-embedded bacteria more resistant antibiotics immune system, they extremely difficult treat. Therefore, biofilm-active a major challenge. Here we investigated effect of lantibiotic gallidermin on two representative biofilm-forming staphylococcal species. Gallidermin inhibits not only growth staphylococci...
Holarrhena antidysenterica has been employed as an ethnobotanical plant for the treatment of dysentery, diarrhoea, fever, and bacterial infections. Biological activities principle compound, conessine including anti-diarrhoea anti-plasmodial effects were documented. Our previous study reported potency extract resistance modifying agents against extensively drug-resistant Acinetobacter baumannii. This aimed to investigate (i) whether conessine, a steroidal alkaloid could act agent...
Punica granatum (P. granatum) Linn. pericarp has been commonly employed as a crude drug in Thai traditional medicines for the treatment of diarrhea. The antibacterial activity extracts from P. against different strains enterohemorrhagic Escherichia coli (E. coli) O157 : H7 and other E. were investigated. Successive chloroform, 95% ethanol, water plant examined. ethanolic extract was found to be most effective all Both ethyl acetate n-butanol fractions demonstrated have high with highest...
Biofilm formation has been demonstrated as a potentially important mechanism contributing to antibiotic treatment failure on Streptococcus pyogenes. It could play significant role in recurrent and chronic infections. Boesenbergia pandurata (Roxb.) Schltr., Eleutherine americana Merr. Rhodomyrtus tomentosa (Aiton) Hassk. have previously reported from our laboratory effective agents against S. Therefore, the present study, we observed effect of these plants biofilm formation. The bacterial...
The ethanolic extract from Rhodomyrtus tomentosa leaf exhibited good antibacterial activities against both methicillin-resistant Staphylococcus aureus (MRSA) and S. ATCC 29213. Its minimal inhibitory concentration (MIC) values ranged 31.25–62.5 µg/ml, the bactericidal (MBC) was 250 µg/ml. Rhodomyrtone, an acylphloroglucinol derivative, 62.5–125 times more potent at inhibiting bacteria than extract, MIC MBC were 0.5 µg/ml 2 respectively. To provide insights into mechanisms involved, effects...
Staphyloxanthin is the eponymous feature of human pathogen Staphylococcus aureus, and pigment promotes resistance to reactive oxygen species host neutrophil-based killing. To probe possible use rhodomyrtone isolated from Rhodomyrtus tomentosa (Aiton) Hassk. leaves inhibit production in S. experiments were carried out compare susceptibility rhodomyrtone-treated aureus untreated cells oxidants vitro. In addition, we observed innate immune clearance after incubation with using an ex vivo assay...
The acylphloroglucinol rhodomyrtone is a promising new antibiotic isolated from the rose myrtle Rhodomyrtus tomentosa, plant used in Asian traditional medicine. While many studies have demonstrated its antibacterial potential variety of clinical applications, very little known about mechanism action rhodomyrtone. Preceding been focused on intracellular targets, but no specific protein could be confirmed as main target. Using live cell, high-resolution, and electron microscopy we demonstrate...
Multidrug resistant Enterobacterales have become a serious global health problem, with extended hospital stay and increased mortality. Antibiotic monotherapy has been reported ineffective against most drug bacteria including Klebsiella pneumoniae , thus encouraging the use of multidrug therapies as an alternative antibacterial strategy. The present works assessed activity colistin K . isolates. Resistant isolates were tested 16 conventional antibiotics alone in combination colistin. results...
The emergence of antibiotic resistance has seriously diminished efficacy and an increasing number infections are becoming difficult to treat. One approach the restoration activity is administer them in conjunction with non-antibiotic compounds that depress mechanisms. We describe ellagic tannic acids as adjuvants enhance aminocoumarin antibiotics against multidrug-resistant (MDR) Acinetobacter baumannii.Adjuvant plant phenolics was tested using growth inhibition assays combination...
The anti-staphylococcal activity of an ethanol extract Rhodomyrtus tomentosa and its pure compound, rhodomyrtone, as well their effects on staphylococcal biofilm formation biofilm-grown cells were assessed. MIC minimal bactericidal concentration values the rhodomyrtone against planktonic cultures biofilms five clinical strains each Staphylococcus aureus epidermidis, American Type Culture Collection (ATCC) both species, 32-512 0.25-2 µg ml(-1), respectively. Results from time-kill studies...