A5006805821- Magnetic Properties of Alloys
- Sleep and Wakefulness Research
- Magnetic and transport properties of perovskites and related materials
- Gastric Cancer Management and Outcomes
- Drug Transport and Resistance Mechanisms
- Sphingolipid Metabolism and Signaling
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Magnetic properties of thin films
- Marine Bivalve and Aquaculture Studies
- Corneal surgery and disorders
- Sleep and related disorders
- Estrogen and related hormone effects
- Low-power high-performance VLSI design
- Calcium Carbonate Crystallization and Inhibition
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Circadian rhythm and melatonin
- Cancer Research and Treatments
- Complex Network Analysis Techniques
- Glutathione Transferases and Polymorphisms
- Corneal Surgery and Treatments
- Metallic Glasses and Amorphous Alloys
- Genomics, phytochemicals, and oxidative stress
- Immune cells in cancer
Takeda (Japan)
2011-2025
Tokyo Medical University
2018-2025
National Center For Child Health and Development
2019-2025
Beth Israel Deaconess Medical Center
2025
Harvard University
2025
Jikei University School of Medicine
1989-2024
National Institute for Japanese Language and Linguistics
2024
Japan Advanced Institute of Science and Technology
2023
Sumitomo Metal Mining (Japan)
1990-2022
Yokohama City University
1997-2022
The study of the pearl oyster Pinctada fucata is key to increasing our understanding molecular mechanisms involved in biosynthesis and biology bivalve molluscs. We sequenced ∼1150-Mb genome at ∼40-fold coverage using Roche 454 GS-FLX Illumina GAIIx sequencers. sequences were assembled into contigs with N50 = 1.6 kb (total contig assembly reached 1024 Mb) scaffolds 14.5 kb. AT-rich, a GC content 34%. DNA transposons, retrotransposons, tandem repeat elements occupied 0.4, 1.5, 7.9% genome,...
This paper describes an automated design technique to reduce power by making use of two supply voltages. The consists structure synthesis, placement, and routing. synthesizer clusters the gates off critical paths so as reduced voltage save power. placement routing tool assigns either or unreduced one each row minimize area overhead. supply, is also exploited in a clock tree Combining these techniques together, we applied it media processor chip. combined 47% random-logic modules 73% tree,...
This paper describes clock recovery circuits specifically designed for the hostile noise environment found aboard dynamic RAM chips. Instead of a phase-locked loop having voltage-controlled oscillator, these implement delay-locked loop, thereby achieving low jitter and reduced sensitivity to on substrate power supply rails. Differential signals are employed both in signal paths control paths, further decreasing simultaneously allowing operation from voltage supplies. An unorthodox controlled...
Narcolepsy type 1 (NT1) is a sleep disorder caused by loss of orexinergic neurons. 2 (NT2) heterogeneous; affected individuals typically have normal orexin levels. Following evaluation in mice, the effects receptor (OX2R)-selective agonist danavorexton were evaluated single- and multiple-rising-dose studies healthy adults, with NT1 NT2. In orexin/ataxin-3 narcolepsy reduced sleep/wakefulness fragmentation cataplexy-like episodes during active phase. humans, administered intravenously was...
Vascular endothelial growth factor-A (VEGFA) is a key inducer of angiogenesis, responsible for generating new blood vessels in the tumor microenvironment (TME) and facilitating metastasis. Notably, Avastin, which targets VEGFA, failed to demonstrate any significant benefit clinical trials breast cancer (BC). This study aimed investigate relevance VEGFA gene expression BC. A total 7,336 BC patients across eight independent cohorts: ISPY2 (GSE173839), Sweden Cancerome Analysis Network-Breast...
The orexin 2 receptor-selective agonist danavorexton (TAK-925) has been shown to produce wake-promoting effects in wild-type mice, narcolepsy-model and individuals with narcolepsy type 1 2. Here, we report of non-human primates healthy men during their sleep phase. Electroencephalogram analyses revealed that subcutaneous administration significantly increased wakefulness common marmosets (p < 0.05 at 0.1 mg kg-1 , p 0.001 10 ) cynomolgus monkeys ≤ 3 ). In a phase 1b crossover, randomized,...
A 60-mW MPEG4 video codec has been developed for mobile multimedia applications. This supports both the H.263 ITU-T recommendation and simple profile of committee draft version 1 released in November 1997. It is composed a 16-bit reduced instruction set computer processor several dedicated hardware engines so as to satisfy power efficiency programmability. performs 10 frames/s encoding decoding with quarter-common intermediate format at 30 MHz. Several innovative low-power techniques were...
A novel design technique which combines a variable supply-voltage scheme and clustered voltage scaling is presented (VS-CVS scheme). theory to choose the optimum supply voltages in VS-CVS discussed enables us perform chip top-down fashion. Level-shifting flip-flops are developed reduce power, delay area penalties significantly. Application of this an MPEG4 video codec saves 55% power dissipation without degrading circuit performance compared conventional CMOS design.
A cDNA clone derived from a human hepatocellular carcinoma has been isolated on the basis of homology to α retinoic acid receptor (RARα) gene. Expression this produces high affinity nuclear binding protein for acid. The product when expressed in transfected cells is able activate transcription reporter plasmid through specific DNA sequences response addition medium. Dose-dependent profiles upon trans-activation indicate that apparent sensitivity approximately 10-fold higher than RARα and...
A glutathione (GSH) S-transferase (GST), catalyzing the inactivation of reactive sulfate esters as metabolites carcinogenic arylmethanols, was isolated from male Sprague-Dawley rat liver cytosol and purified to homogeneity in 12% yield with a purification factor 901-fold. The GST homo-dimeric enzyme protein subunit Mr 26,000 pI 7.9 designated Yrs-Yrs because its activity toward esters. could neither be retained on S-hexylglutathione gel column nor showed any 1,2-dichloro-4-nitrobenzene,...
Haploinsufficiency of A20 (HA20) is caused by loss-of-function TNFAIP3 variants. Phenotypic and genetic features HA20 remain uncertain; therefore, the clinical distinction between Behçet's disease (BD) requires clarification.We have collected 12 Japanese BD-like families. Probands these families were analyzed whole exome sequencing (WES) subsequent Sanger sequencing. Clinical compared 54 patients (including previously reported new cases) 520 BD patients.We identified c.1434C>A:p.(Cys478*) in...
TAK-925, a potent, selective, and brain-penetrant orexin 2 receptor (OX2R) agonist, [methyl (2R,3S)-3-((methylsulfonyl)amino)-2-(((cis-4-phenylcyclohexyl)oxy)methyl)piperidine-1-carboxylate, 16], was identified through the optimization of compound 2, which discovered by high throughput screening (HTS) campaign. Subcutaneous administration 16 produced wake-promoting effects in mice during sleep phase. Compound (TAK-925) is being developed for treatment narcolepsy other related disorders.
Loss of orexin neurons is associated with narcolepsy type 1 (NT1), which characterized by multiple symptoms including excessive daytime sleepiness and cataplexy. Orexin 2 receptor (OX2R) knockout (KO) mice, but not (OX1R) KO show narcolepsy-like phenotypes, thus OX2R agonists are potentially promising for treating NT1. In fact, in early proof-of-concept studies, intravenous infusion danavorexton, an OX2R-selective agonist, significantly increased wakefulness individuals However, danavorexton...
Recent studies have suggested that cardiac troponin T (cTnT) and I may detect ongoing myocardial damage involved in the progression of chronic heart failure (CHF). This study was prospectively designed to examine whether combination cTnT, a marker for damage, B-type natriuretic peptide (BNP), left ventricular overload, would effectively stratify patients with CHF after initiation treatment.We measured serum plasma BNP, ejection fraction (LVEF) on admission worsening [New York Heart...
A new acidic form of glutathione S ‐transferase (GST, pI 6.2) was purified from rat brain by ‐hexylglutathione affinity chromatography followed chromatofocusing. This occupied 20–25% the total activity bound to column. It had a molecular mass (subunit 26 kDa) similar that major GST testis (M T or 6‐6) on sodium dodecyl sulfate/polyacrylamide gel electrophoresis. However, it differed M in isoelectric point, towards 1,2‐dichloro‐4‐nitrobenzene and immunological properties. On two‐dimensional...
We present a low-power design method that utilizes the multiple supply voltages. The proposed reduces power consumption of random logic circuits by 47% on average, with up to 15% area overhead, combination Clustered Voltage Scaling (CVS) scheme and Row optimized Power Supply (RRPS) scheme. By CVS scheme, optimal netlist, uses minimized number level converters maximized low Vdd gates under timing constraints, is generated. To avoid wiring resource increase interconnect delay caused layout...
The role of NF-κB, the rapid-response transcription factor for multiple genes, in cold ischemia-reperfusion (I/R) injury was examined after syngeneic transplantation liver grafts. Lewis rat recipients were killed 1–48 h reperfusion three different grafts: 1) uninfected control, 2) infected ex vivo with control adenoviral vector (AdEGFP), and 3) AdIκB. In livers, NF-κB activated biphasically at 1–3 12 aspartate transaminase (AST) levels 4,244 ± 691 IU/l. first peak activation associated an...