A5077439573- Genomics and Phylogenetic Studies
- Chromosomal and Genetic Variations
- Animal Genetics and Reproduction
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genetic diversity and population structure
- Parkinson's Disease Mechanisms and Treatments
- Marine Bivalve and Aquaculture Studies
- RNA Research and Splicing
- RNA modifications and cancer
- Aquaculture disease management and microbiota
- Physiological and biochemical adaptations
- Nuclear Receptors and Signaling
- Calcium Carbonate Crystallization and Inhibition
- Congenital heart defects research
- Identification and Quantification in Food
- Genetics and Neurodevelopmental Disorders
- CRISPR and Genetic Engineering
- Aquaculture Nutrition and Growth
- MicroRNA in disease regulation
- RNA and protein synthesis mechanisms
- Developmental Biology and Gene Regulation
- Glycosylation and Glycoproteins Research
- Muscle Physiology and Disorders
- Genomics and Chromatin Dynamics
- Ubiquitin and proteasome pathways
The University of Tokyo
2016-2025
Aquatic Systems (United States)
2014-2022
Tokyo Woman's Christian University
2005-2018
Tohoku University
2018
Keio University
2003-2016
Tokyo University of Agriculture
2010
Keio University Hospital
1996-2009
National Institute of Genetics
2007
Niigata University
2007
National Institute for Basic Biology
2007
Chromosome 21 is the smallest human autosome. An extra copy of chromosome causes Down syndrome, most frequent genetic cause significant mental retardation, which affects up to 1 in 700 live births. Several anonymous loci for monogenic disorders and predispositions common complex have also been mapped this chromosome, loss heterozygosity has observed regions associated with solid tumours. Here we report sequence gene catalogue long arm 21. We sequenced 33,546,361 base pairs (bp) DNA very high...
The medaka fish (Oryzias latipes) is a popular pet in Japan and more recently laboratory model organism for developmental genetics evolutionary biology. Now the medaka's genome has been sequenced analysed by large Japanese consortium. Cichlids stickleback, which are emerging systems understanding genetic basis of vertebrate speciation, evolutionarily closer to than zebrafish, so sequence will yield valuable insights into 400 million years evolution. long organism; it now its Teleosts...
Small, compact genomes of ultrasmall unicellular algae provide information on the basic and essential genes that support lives photosynthetic eukaryotes, including higher plants1,2. Here we report 16,520,305-base-pair sequence 20 chromosomes red alga Cyanidioschyzon merolae 10D as first complete algal genome. We identified 5,331 in total, which at least 86.3% were expressed. Unique characteristics this genomic structure include: a lack introns all but 26 genes; only three copies ribosomal...
The genes that determine the development of male or female sex are known in Caenorhabditis elegans , Drosophila and most mammals. In many other organisms existence sex-determining factors has been shown by genetic evidence but unknown. We have found fish medaka Y chromosome-specific region spans only about 280 kb. It contains a duplicated copy autosomal DMRT1 gene, named DMRT1Y . This is functional gene this chromosome segment maps precisely to locus. expressed during embryonic larval...
The study of the pearl oyster Pinctada fucata is key to increasing our understanding molecular mechanisms involved in biosynthesis and biology bivalve molluscs. We sequenced ∼1150-Mb genome at ∼40-fold coverage using Roche 454 GS-FLX Illumina GAIIx sequencers. sequences were assembled into contigs with N50 = 1.6 kb (total contig assembly reached 1024 Mb) scaffolds 14.5 kb. AT-rich, a GC content 34%. DNA transposons, retrotransposons, tandem repeat elements occupied 0.4, 1.5, 7.9% genome,...
Abstract Autosomal recessive juvenile parkinsonism (AR‐JP) is a distinct clinical and genetic entity characterized by selective degeneration of nigral dopaminergic neurons young‐onset with remarkable response to levodopa. Recently, we mapped the gene locus for AR‐JP chromosome 6q25.2–q27 linkage analysis identified novel large gene, Parkin , consisting 12 exons from this region; mutations were found be cause in two families. Now report results extensive molecular on 34 affected individuals...
Autosomal recessive juvenile parkinsonism (AR-JP) is a distinct clinical entity characterized by selective degeneration of nigral neurons. Recently, the parkin gene responsible for AR-JP has been identified. Now, we report subcellular localization Parkin protein in patients with or Parkinson's disease (PD) and controls immunoblotting immunohistochemistry using antibodies raised against molecule. was absent all regions brains AR-JP. not decreased sporadic PD patients. Immunoreactivity...
We previously performed mutant screens in the medaka for defects gonadal development and identified a of interest this regard, which was designated as hotei (hot). This manifests number remarkable phenotypic abnormalities including: (i) excessive proliferation germ cells that initiates at around hatching stage regardless genetic sex fish; (ii) initiation premature meiosis phenotypically male hot homozygotes; (iii) one-half hot-homozygous XY fish undergo reversal, accompanies expression...
Sequencing of the human Y chromosome has uncovered peculiarities genomic organization a heterogametic sex old evolutionary age, and led to many insights into changes that occurred during its long history. We have studied medaka fish chromosome, which is one youngest chromosomes on molecular data are available. The specific adjacent regions were sequenced compared X. male sex-determining gene, dmrt1bY, appears be only functional gene in Y-specific region. region itself derived from...
Bivalve molluscs have flourished in marine environments, and many species constitute important aquatic resources. Recently, whole genome sequences from two bivalves, the pearl oyster, Pinctada fucata, Pacific Crassostrea gigas, been decoded, making it possible to compare genomic among molluscs, explore general lineage-specific genetic features trends bivalves. In order improve quality of sequence data for these purposes, we updated entire P. fucata assembly. We present a new assembly...
Background Despite its economic importance, we have a limited understanding of the molecular mechanisms underlying shell formation in pearl oysters, wherein calcium carbonate crystals, nacre and prism, are formed highly controlled manner. We constructed comprehensive expressed gene profiles shell-forming tissues oyster Pinctada fucata identified novel formation-related genes candidates. Principal Findings employed GS FLX 454 system transcriptome data sets from pallial mantle sac, which form...
The ribosome, as a catalyst for protein synthesis, is universal and essential all organisms. Here we describe the structure of genes encoding human ribosomal proteins (RPs) compare this class among several eukaryotes. Using genomic full-length cDNA sequences, characterized 73 RP found that (1) transcription starts at C residue within characteristic oligopyrimidine tract; (2) promoter region GC rich, but often has TATA box or similar sequence element; (3) are small (4.4 kb), have many 5.6...
Two W chromosome–linked cDNA clones, p5fm2 and p5fm3, were obtained from a subtracted (female minus male) library prepared mixture of undifferentiated gonads mesonephroi male or female 5-d (stages 26–28) chicken embryos. These two clones demonstrated to be derived the mRNA encoding an altered form PKC inhibitor/interacting protein (PKCI), its gene was namedWpkci. The Wpkci reiterated ∼40 times tandemly located at nonheterochromatic end chromosome. linkage moderate reiteration ofWpkci...