A5055071992- Marine Ecology and Invasive Species
- Acute Myocardial Infarction Research
- Ichthyology and Marine Biology
- Marine Bivalve and Aquaculture Studies
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Calcium Carbonate Crystallization and Inhibition
- Marine Invertebrate Physiology and Ecology
- Lipoproteins and Cardiovascular Health
- Genomics and Phylogenetic Studies
- Coronary Interventions and Diagnostics
- Fish Biology and Ecology Studies
- Identification and Quantification in Food
- Marine Biology and Ecology Research
- Developmental Biology and Gene Regulation
- Venomous Animal Envenomation and Studies
- Cephalopods and Marine Biology
- Marine Biology and Environmental Chemistry
- Heart Failure Treatment and Management
- Parasite Biology and Host Interactions
- Antimicrobial Peptides and Activities
- Protist diversity and phylogeny
- Antiplatelet Therapy and Cardiovascular Diseases
- Viral Infections and Immunology Research
- Silk-based biomaterials and applications
Hosei University
2025
Okinawa Institute of Science and Technology Graduate University
2013-2022
Hokkaido University Hospital
2021-2022
Weatherford College
2021
Japan Biological Informatics Consortium
2021
Nagasaki University Hospital
2021
Tokyo Women's Medical University
2008-2020
Tokyo University of Agriculture and Technology
2008-2013
Hokkaido University
2006-2010
University of Zurich
2003
Coral reefs are among the most biologically diverse ecosystems on planet and of great economic importance. They under threat because scleractinian corals at their core susceptible to ocean acidification rising seawater temperatures. The genome reef-building coral Acropora digitifera has been analysed with a view understanding molecular basis symbiosis responses environmental change. seems have lost key enzyme cysteine biosynthesis, so may be dependent its symbionts for this amino acid. It...
The study of the pearl oyster Pinctada fucata is key to increasing our understanding molecular mechanisms involved in biosynthesis and biology bivalve molluscs. We sequenced ∼1150-Mb genome at ∼40-fold coverage using Roche 454 GS-FLX Illumina GAIIx sequencers. sequences were assembled into contigs with N50 = 1.6 kb (total contig assembly reached 1024 Mb) scaffolds 14.5 kb. AT-rich, a GC content 34%. DNA transposons, retrotransposons, tandem repeat elements occupied 0.4, 1.5, 7.9% genome,...
Acorn worms, also known as enteropneust (literally, 'gut-breathing') hemichordates, are marine invertebrates that share features with echinoderms and chordates. Together, these three phyla comprise the deuterostomes. Here we report draft genome sequences of two acorn Saccoglossus kowalevskii Ptychodera flava. By comparing them diverse bilaterian genomes, identify shared traits were probably inherited from last common deuterostome ancestor, then explore evolutionary trajectories leading this...
Abstract The evolutionary origins of lingulid brachiopods and their calcium phosphate shells have been obscure. Here we decode the 425-Mb genome Lingula anatina to gain insights into brachiopod evolution. Comprehensive phylogenomic analyses place close molluscs, but distant from annelids. gene number has increased ∼34,000 by extensive expansion families. Although vertebrates superficially similar hard tissue components, our genomic, transcriptomic proteomic show that lacks genes involved in...
Bivalve molluscs have flourished in marine environments, and many species constitute important aquatic resources. Recently, whole genome sequences from two bivalves, the pearl oyster, Pinctada fucata, Pacific Crassostrea gigas, been decoded, making it possible to compare genomic among molluscs, explore general lineage-specific genetic features trends bivalves. In order improve quality of sequence data for these purposes, we updated entire P. fucata assembly. We present a new assembly...
Anhydrobiosis represents an extreme example of tolerance adaptation to water loss, where organism can survive in ametabolic state until returns. Here we report the first comparative analysis examining genomic background desiccation tolerance, which is exclusively found larvae only anhydrobiotic insect, Polypedilum vanderplanki. We compare genomes P. vanderplanki and a congeneric desiccation-sensitive midge nubifer. determine that genome species specifically contains clusters multi-copy genes...
The marine dinoflagellate, Symbiodinium, is a well-known photosynthetic partner for coral and other diverse, non-photosynthetic hosts in subtropical tropical shallows, where it comprises an essential component of ecosystems. Using molecular phylogenetics, the genus Symbiodinium has been classified into nine major clades, A-I, one reported differences among phenotypes their capacity to synthesize mycosporine-like amino acids (MAAs), which absorb UV radiation. However, genetic basis this...
Abstract Nemerteans (ribbon worms) and phoronids (horseshoe are closely related lophotrochozoans—a group of animals including leeches, snails other invertebrates. Lophotrochozoans represent a superphylum that is crucial to our understanding bilaterian evolution. However, given the inconsistency molecular morphological data for these groups, their origins have been unclear. Here, we present draft genomes nemertean Notospermus geniculatus phoronid Phoronis australis , together with...
To elucidate the effects of intensive LDL-C lowering treatment with a standard dose statin and ezetimibe in patients dyslipidaemia high risk coronary events, targeting less than 70 mg/dL (1.8 mmol/L), compared lipid monotherapy 100 (2.6 mmol/L).The HIJ-PROPER study is prospective, randomized, open-label trial to assess whether standard-dose pitavastatin plus reduces cardiovascular events more acute syndrome (ACS) dyslipidaemia. Patients were randomized (target < [1.8 mmol/L]; ezetimibe) or...
Cnidarians are astonishingly diverse in body form and lifestyle, including the presence of a jellyfish stage medusozoans its absence anthozoans. Here, we sequence genomes Aurelia aurita (a scyphozoan) Morbakka virulenta cubozoan) to understand molecular mechanisms responsible for origin plan. We show that magnitude genetic differences between two types is equivalent, on average, level humans sea urchins bilaterian lineage. About one-third genes with jellyfish-specific expression have no...
Validation and standardization of methodologies for microbial community measurements by high-throughput sequencing are needed to support human microbiome research its industrialization. This study set out establish standards-based solutions improve the accuracy reproducibility metagenomics-based profiling fecal samples.
<h3>Objective:</h3> To determine the incidence of sudden cardiac death (SCD) according to left ventricular ejection fraction (LVEF) in survivors myocardial infarction (MI) primary percutaneous coronary intervention (PCI) era. <h3>Design:</h3> A multicentre observational prospective registered cohort study. <h3>Setting:</h3> 18 medical centres Japan. <h3>Patients:</h3> 4122 consecutive patients (mean age 66 (SD 12) years, 73.7% male) with acute MI, who were discharged alive. <h3>Main outcome...
Genome sequencing of Symbiodinium minutum revealed that 95 109 plastid-associated genes have been transferred to the nuclear genome and subsequently expanded by gene duplication. Only 14 remain in plastids occur as DNA minicircles. Each minicircle (1.8-3.3 kb) contains one a conserved noncoding region containing putative promoters RNA-binding sites. Nine types RNA editing, including novel G/U type, were discovered transcripts but not nucleus. In contrast editing sites dinoflagellate...
Abstract Evolution of novel traits is a challenging subject in biological research. Several snake lineages developed elaborate venom systems to deliver complex protein mixtures for prey capture. To understand mechanisms involved evolution, we decoded here the ~1.4-Gb genome habu, Protobothrops flavoviridis . We identified 60 genes (SV) and 224 non-venom paralogs (NV), belonging 18 gene families. Molecular phylogeny reveals early divergence SV NV genes, suggesting that one four copies...
Molluscan shells, mainly composed of calcium carbonate, also contain organic components such as proteins and polysaccharides. Shell matrices construct frameworks shell structures regulate crystallization processes during formation. To date, a number matrix (SMPs) have been identified, their functions in formation studied. However, previous studies focused only on SMPs extracted from adult secreted after metamorphosis. Using proteomic analyses combined with genomic transcriptomic analyses, we...
Two new species of Rhinogobius found in streams on central part Palawan Island, Philippines are described. The two species, estrellae and tandikan share unique transverse rows sensory papillae the cheek with similis Gill, 1859, but differ from latter fin ray counts, arrangement scales, etc. distinguished each other by pectoral-fin count, longitudinal- predorsal-scale colouration body. R. have been allopatrically a stream within Malatgao River system flowing into Sulu Sea Cayulo South China...
The long-term prognosis of diabetic patients with acute myocardial infarction (AMI) treated by revascularization is uncertain, and the optimal pharmacotherapy for such cases has not been fully evaluated.To elucidate prognostic factors in AMI, a prospective, cohort study involving 3021 consecutive AMI was conducted. All discharged alive from hospital were followed to monitor their every year. primary endpoint all-cause mortality, secondary occurrence major cardiovascular events. To effect...
Abstract The pond snail Lymnaea stagnalis is capable of learning conditioned taste aversion (CTA) and then consolidating that into long‐term memory (LTM) persists for at least 1 month. LTM requires de novo protein synthesis altered gene activity. Changes in activity are correlated with, much less causative, formation have not yet been identified. As a first step toward rectifying this situation, we constructed cDNA microarray with mRNAs extracted from the central nervous system (CNS) . We...
Abstract Background ParaHox and Hox genes are thought to have evolved from a common ancestral ProtoHox cluster or tandem duplication prior the divergence of cnidarians bilaterians. Similar clusters, chordate including Gsx , Xlox Cdx clustered their expression exhibits temporal spatial colinearity. In non-chordate animals, however, studies on genomic organization limited only few animal taxa. Hemichordates, such as Enteropneust acorn worms, been used gain insights into origins characters....
Labyrinthulomycetes have been regarded as a promising industrial source of xanthophylls, including astaxanthin and canthaxanthin, polyunsaturated fatty acids such docosahexaenoic acid docosapentaenoic acid, ω-3 oils, terpenic hydrocarbons, sterols squalene. A Thraustochytrid, Aurantiochytrium sp. KH105 produces carotenoids, astaxanthin, with strong antioxidant activity. To gain genomic insights into this capacity, we decoded its 97-Mbp genome characterized genes for enzymes involved in...
In the open ocean without terrain boundaries, marine invertebrates with pelagic larvae can migrate long distances using currents, suggesting reduced genetic diversification. Contrary to this assumption, however, differentiation is often observed in invertebrates. present study, we sought explain how population structure established western Pacific Ocean, where strong Kuroshio Current maintains high levels of gene flow from south north, presumably promoting homogeneity. We determined pearl oyster,