Wolfgang Zimmermann
A5031960495- Monoclonal and Polyclonal Antibodies Research
- Radiopharmaceutical Chemistry and Applications
- Immunotherapy and Immune Responses
- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- Cell Adhesion Molecules Research
- Peptidase Inhibition and Analysis
- CAR-T cell therapy research
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Reproductive System and Pregnancy
- Cancer Research and Treatments
- Renal and related cancers
- Prostate Cancer Treatment and Research
- Glycosylation and Glycoproteins Research
- Rings, Modules, and Algebras
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Virus-based gene therapy research
- Pregnancy and preeclampsia studies
- Lung Cancer Treatments and Mutations
- Archaeology and Historical Studies
- Advanced Topics in Algebra
- Algebraic structures and combinatorial models
- Lung Cancer Research Studies
Ludwig-Maximilians-Universität München
2013-2024
Berufsgenossenschaftliche Unfallklinik Murnau
2012-2024
LMU Klinikum
2006-2023
Institut für Medien- und Kommunikationspolitik
2023
German Studies Association
2022
Ontotext (Bulgaria)
2022
Federal Foreign Office
2022
Landesarchiv
2022
Chemical Genomics Centre
2011-2021
University Medical Center
2018
Chromosome 21 is the smallest human autosome. An extra copy of chromosome causes Down syndrome, most frequent genetic cause significant mental retardation, which affects up to 1 in 700 live births. Several anonymous loci for monogenic disorders and predispositions common complex have also been mapped this chromosome, loss heterozygosity has observed regions associated with solid tumours. Here we report sequence gene catalogue long arm 21. We sequenced 33,546,361 base pairs (bp) DNA very high...
Leishmania species cause a spectrum of human diseases in tropical and subtropical regions the world. We have sequenced 36 chromosomes 32.8-megabase haploid genome major (Friedlin strain) predict 911 RNA genes, 39 pseudogenes, 8272 protein-coding which 36% can be ascribed putative function. These include genes involved host-pathogen interactions, such as proteolytic enzymes, extensive machinery for synthesis complex surface glycoconjugates. The organization into long, strand-specific,...
Abstract Purpose: The inflammatory enzyme indoleamine 2,3-dioxygenase (IDO) participates in immune tolerance and tumor escape processes by degradation of the essential amino acid tryptophan formation toxic catabolites. Here, we analyzed role IDO growth disease progression patients with clear cell renal carcinoma (RCC). Experimental Design: Expression mRNA was quantitative reverse transcription-PCR 55 primary 52 metastatic RCC, along 32 normal kidneys. Western blot immunohistochemistry...
In many solid tumors, cancer stem cells (CSC) represent a population with tumor-initiating, self-renewal, and differentiation potential, which can be identified by surface protein markers. No generally applicable markers are yet known for renal cell carcinoma (RCC). Two RCC lines (RCC-26, RCC-53) were found to differ widely in their capacity form spheres vitro establish tumors mice, potentially reflecting differences CSC content. A subpopulation expressing the CXC chemokine receptor 4...
Carcinoembryonic antigen (CEA) is a widely used tumor marker, especially in the surveillance of colonic cancer patients. Although CEA also present some normal tissues, it apparently expressed at higher levels tumorous tissues than corresponding tissues. As first step toward analyzing regulation expression transcriptional level, we have isolated and characterized cosmid clone (cosCEA1), which contains entire coding region gene. A close correlation exists between exon deduced...
For the isolation of cDNA clones encoding carcinoembryonic antigen (CEA), we have constructed a library from human colon tumor mRNA. The was screened with various oligonucleotides whose sequence had been deduced partial amino acid data for CEA. Positive candidate were hybridized probe repetitive DNA, because CEA mRNA contains an Alu element, and fragment genomic clone nonspecific cross-reacting antigen, closely related to Here report nucleotide two overlapping comprising 1422 nucleotides...
We sequenced the envelope (env) gene and 3' long terminal repeat of a Friend mink cell focus-inducing virus (F-MCFV). also gp70 coding regions for two cDNA clones another F-MCFV. The deduced amino acid sequence env products both F-MCFVs were compared to corresponding sequences other MCFVs ecotropic viruses. polypeptides different viruses showed stretches homology in carboxy-terminal half p15env ("constant region"). amino-terminal was very similar all MCFVs, but extensive variations relative...
Most rapidly evolving gene families are involved in immune responses and reproduction, two biological functions which have been assigned to the carcinoembryonic antigen (CEA) family. To gain insights into evolutionary forces shaping CEA family we analysed this 27 mammalian species including monotreme marsupial lineages. Phylogenetic analysis provided convincing evidence that primordial mammals consisted of five genes, inhibitory receptor-encoding CEACAM1 (CEA-related cell adhesion molecule)...
Streptococcus mitis is the closest relative of major human pathogen S. pneumoniae. The 2,15 Mb sequence B6 chromosome, an unusually high-level beta-lactam resistant and multiple antibiotic strain, has now been determined to encode 2100 genes. accessory genome estimated represent over 40%, including 75 mostly novel transposases IS, prophage φB6 another seven phage related regions. Tetracycline resistance mediated by Tn5801, unusual large gene cluster containing three aminoglycoside...
Colonization of mucosal surfaces is the key initial step in most bacterial infections. One mechanism protecting mucosa rapid shedding epithelial cells, also termed exfoliation, but it unclear how pathogens counteract this process. We found that carcinoembryonic antigen (CEA)-binding bacteria colonized urogenital tract CEA transgenic mice, not wild-type by suppressing exfoliation cells. binding triggered de novo expression transforming growth factor receptor CD105, changing focal adhesion...