A5039823992- Electron and X-Ray Spectroscopy Techniques
- Advanced Chemical Physics Studies
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Surface and Thin Film Phenomena
- X-ray Spectroscopy and Fluorescence Analysis
- Ion-surface interactions and analysis
- Mass Spectrometry Techniques and Applications
- Cardiovascular Disease and Adiposity
- Particle Accelerators and Free-Electron Lasers
- Semiconductor materials and devices
- Stroke Rehabilitation and Recovery
- Glutathione Transferases and Polymorphisms
- Graphene research and applications
- Cardiovascular and exercise physiology
- Cerebrovascular and Carotid Artery Diseases
- Physical Activity and Health
- Chalcogenide Semiconductor Thin Films
- Atomic and Molecular Physics
- Advanced X-ray Imaging Techniques
- Organ Transplantation Techniques and Outcomes
- Cardiovascular Function and Risk Factors
- Advanced Electron Microscopy Techniques and Applications
- Molecular Junctions and Nanostructures
- Particle accelerators and beam dynamics
Asahi University
2019-2025
SPring-8 (Japan)
2017-2025
Takeda (United States)
2025
Toyooka Hospital
2011-2024
Musashigaoka College
2022-2024
Osaka University
2008-2023
Osaka Research Institute of Industrial Science and Technology
2003-2023
Weatherford College
2023
Takeda (Japan)
2018-2022
Dokkyo Medical University Saitama Medical Center
2021
Limited proteolysis of three distinct subspecies protein kinase C (Ca2+/phospholipid-dependent enzyme, PKC), types I (γ), II (βI and βII), III (α), with Ca2+-dependent neutral proteases (calpains II) was studied. All forms PKC (82 kDa) were converted to two major fragments: a 45–49-kDa catalytic fragment 36-kDa regulatory fragment. The cleavage these by calpain (active in the micromolar range Ca2+/ion concentration), and, lesser extent, millimolar range), enhanced simultaneous presence...
Narcolepsy type 1 (NT1) is a sleep disorder caused by loss of orexinergic neurons. 2 (NT2) heterogeneous; affected individuals typically have normal orexin levels. Following evaluation in mice, the effects receptor (OX2R)-selective agonist danavorexton were evaluated single- and multiple-rising-dose studies healthy adults, with NT1 NT2. In orexin/ataxin-3 narcolepsy reduced sleep/wakefulness fragmentation cataplexy-like episodes during active phase. humans, administered intravenously was...
NanoTerasu, a new 3 GeV synchrotron light source in Japan, began user operation April 2024. It provides high-brilliance soft to tender x-rays and covers wide spectral range from ultraviolet x-rays. Its compact storage ring with circumference of 349 m is based on four-bend achromat lattice provide two straight sections each cell for insertion devices natural horizontal emittance 1.14 nm rad, which small enough users. The NanoTerasu accelerator incorporates several innovative technologies,...
In surveys of three groups workers occupationally exposed to polychlorinated biphenyls (PCBs) serum PCB concentrations were quantitated as lower chlorinated (L-PCBs) and higher (H-PCBs). Serum L-PCB H-PCB many times greater among employed in power capacitor manufacturing than areas. Statistically significant positive correlations symptoms suggestive mucous membrane skin irritation, systemic malaise, altered peripheral sensation noted with increasing PCB. No clinical abnormalities...
Background Integrated backscatter (IB) intravascular ultrasound (IVUS) and IVUS Virtual Histology (VH) have been developed for tissue characterization, but never compared directly. The purpose of this study was to compare the overall agreement between IB-IVUS IVUS-VH in characterization plaques from same coronary arterial cross-section. Methods Results Images were acquired 46 arteries 25 cadavers. Of a total 392 histology/IVUS image pairs, 152 pairs diagnosed as Stary's type III, IV, Va, Vb...
Narcolepsy type 1 is a disorder of hypersomnolence caused by loss orexin neurons, which results in low levels the brain. In this phase 2, randomized, placebo-controlled trial, participants with narcolepsy received once- or twice-daily oveporexton (TAK-861), an oral receptor 2-selective agonist, placebo. The primary end point was mean change from baseline to week 8 average sleep latency (the time it takes fall asleep) on Maintenance Wakefulness Test (MWT) (range, 0 40 minutes; normal, ≥20)....
Background — Collateral fractional flow reserve (FFR coll ) is an index to quantify collateral blood flow, derived from coronary pressure measurements. Although well defined theoretically, its direct validation by myocardial perfusion imaging has not been established so far. Validating this the main aim of study. Methods and Results Twenty-four consecutive patients with stable angina single left anterior descending artery stenosis underwent simultaneous measurement aortic (P a ), wedge w...
ABSTRACT We identified a novel, 6,513-bp-long RNA, termed Bombyx mori macula-like latent virus (BmMLV) which abundantly expressed in B. cultured BmN cells. BmMLV RNA potentially encodes two proteins, putative replicase and coat protein, share structural features sequence similarities with those of plant virus, the genus Maculavirus . Northern blot analysis showed that transcripts were cells: 6.5-kb-long contains both protein genes, 1.2-kb-long only gene. Southern is not carried by genome....
The Phase-Induced Amplitude Apodization (PIAA) coronagraph is a high performance concept able to work at small angular separation with little loss in throughput. We present results obtained laboratory PIAA system including active wavefront control. has 94.3% throughput (excluding coating losses) and operates air monochromatic light. Our testbed achieved 2.27e-7 raw contrast between 1.65 lambda/D (inner working angle of the configuration tested) 4.4 (outer angle). Through careful calibration,...
We examined whether stair climbing-descending exercise (ST-EX), a convenient method to increase physical activity in daily life, for short period would acutely improve the postprandial blood glucose (BG) response people with type 2 diabetes (T2D).16 T2D (age 65.4±1.1 years) participated separate sessions. After an overnight fast, each participant consumed test meal and then kept resting 180 min, except when performing 3 min bout of ST-EX at 60 120 after (ST-EX session), or (REST session)....
Two-photon photoemission (2PPE) spectroscopy is used to reveal dynamic relaxation of highly excited electrons generated by 3 eV photons in Si. Monochromatic 2PPE at probe-photon energies ranging from 3.2 3.5 reveals a coherent peak the valence band maximum, and transiently populated near L${}_{1}$ conduction band. Time-resolved measurements show that injected into L valley undergo L-to-X intervalley scattering with time constant 180 fs 293 K. A deformation potential 1.2...
Light is one of the most crucial environmental cues for plants. Phytochrome, major photoreceptors plants, regulates expression many genes. We screened Arabidopsis promoter trap lines that exhibited light-dependent reporter gene expression. Molecular analysis such line revealed a was inserted near an homologue soybean GH3 gene, AtGH3a. performed RNA gel blot to further characterize response AtGH3a light. In end-of-day far-red light treatment, increased substantially. Analysis phyB-deficient...
Improved delivery of macromolecular drugs to solid tumor is known as the enhanced permeability and retention (EPR) effect lipids. We report here that a prostaglandin I2 (PGI2) analogue induces enhancement tumor-selective drug delivery, while it decreases blood flow, in rat model (AH136B). Beraprost sodium (BPS) an PGI2 more stable than parental vivo (t1/2 for BPS >1 h vs. few seconds PGI2). Thus, was administered tumor-bearing rats examine its on vascular well flow. The amount extravasation...
To elucidate the mechanism of plant responses to shading, we identified three promoter/enhancer trap lines (M812, J53, J59) that exhibited reporter expression in hypocotyl response end-of-day far-red light treatment. Interestingly, found auxin-responsive genes vicinities insertion sites M812 and J53. We examined effects auxin on these together with a previously N35 line. The results indicated was induced by exogenous Furthermore, an transport inhibitor inhibited treatment, suggesting...
Au(001) surfaces exhibit a complex reconstructed structure $[\mathrm{Hex}\ensuremath{-}\mathrm{Au}(001)]$ comprising hexagonal surface and square bulk lattices, yielding quasi-one-dimensional corrugated surface. When graphene was grown on this surface, the periodicity of predicted to change electronic graphene, forming bandgaps new Dirac points. Furthermore, graphene--Au interface is promising for bandgap generation spin injection due band hybridization. Here, we report angle-resolved...
This study sought to describe a novel technique for percutaneous transluminal septal myocardial ablation using intracardiac echocardiography (ICE) through the right internal jugular vein (JV) in patients with hypertrophic obstructive cardiomyopathy. Prepare equipment and establish vascular access, insert JV ICE catheter sterile sleeve, perform initial screening obtain key cardiac views, identify target branch coronary angiography ICE, monitor contrast injection ethanol administration real...
Wound healing remains a major challenge in orthopedic surgeries involving thin soft-tissue injuries, such as calcaneal fractures and open wounds. Recent advancements, negative pressure wound therapy, have demonstrated efficacy but practical limitations, patient immobility fall risk, restricting their broader application. Extracorporeal shockwave recognized by the International Society for Medical Shockwave Treatment, has shown potential treating complex wounds, ulcers, burns. However,...
Objective Visit-to-visit variability in SBP (VVV-SBP) is associated with increased cardiac events, including atrial fibrillation (AF). P-wave signal-averaged electrocardiography (P-SAECG) detects subtle conduction abnormalities such as late potential (ALP). This study examined the association between VVV-SBP and conduction. Methods A total of 128 male participants (mean age: 50.8 ± 10.3 years) normal function underwent annual blood pressure measurements over 5 years. was assessed using both...
Each heavy chain of dimeric chick brain myosin V (BMV) has a neck domain consisting six IQ motifs with different amino acid sequences. The form binding sites for five calmodulin (CaM) molecules and one essential light (either 17 or 23 kDa). When the calcium concentration is high, small fraction 10 total CaM dissociates from molecule BMV, resulting in loss actin-based motor activity. At low Ca2+ concentrations, two exogenous associate CaM-released BMV. This suggests that there single specific...
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