A5103183785- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders Research
- Immunodeficiency and Autoimmune Disorders
- Acute Myeloid Leukemia Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- RNA modifications and cancer
- interferon and immune responses
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- Parvovirus B19 Infection Studies
- Lymphoma Diagnosis and Treatment
- Renal and related cancers
- Kawasaki Disease and Coronary Complications
- Neonatal and Maternal Infections
- Congenital Diaphragmatic Hernia Studies
- Hormonal Regulation and Hypertension
- Viral-associated cancers and disorders
- Cancer-related cognitive impairment studies
- Otitis Media and Relapsing Polychondritis
- Sepsis Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Coronary Artery Anomalies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
Kanagawa Children's Medical Center
2020-2025
Tokyo Medical and Dental University
2016-2023
Tokyo Medical and Dental University Hospital
2023
The University of Tokyo
2020-2021
Yokohama City University
2017-2019
Yokohama City University Hospital
2019
Abstract Kawasaki disease (KD) is a systemic vasculitis and childhood febrile that can lead to cardiovascular complications. The diagnosis of KD depends on its clinical features, thus it sometimes difficult make definitive diagnosis. In order identify diagnostic serum biomarkers for KD, we explored KD-related proteins, which differentially expressed during the acute recovery phases two patients by mass spectrometry (MS). We identified total 1,879 proteins MS-based proteomic analysis. levels...
We investigated whether several polymorphisms within the methotrexate (MTX) pathway genes were related to toxicity and efficacy of MTX in 92 Japanese patients with articular-type juvenile idiopathic arthritis (JIA).Eight gene genes, namely, RFC, BCRP, MTHFR (two), FPGS, γ-glutamyl hydrolase (GGH; two) ATIC, genotyped using TaqMan assays. Liver dysfunction was defined as an increase alanine transaminase five times normal upper limit. Non-responders refractory therefore treated biologics.The...
Nakajo-Nishimura syndrome (NNS) is an immunoproteasome-associated autoinflammatory disorder caused by a mutation of the PSMB8 gene. Although dysfunction immunoproteasome causes various cellular stresses attributed to overproduction inflammatory cytokines and chemokines in NNS, underlying mechanisms autoinflammation are still largely unknown. To investigate understand signal pathways we established panel isogenic pluripotent stem cell (PSC) lines with mutation. Activity PSMB8-mutant...
10027 Background: More treatment (tx) options to improve efficacy and long-term safety minimize adverse effects on growth are needed for pediatric patients (pts) with Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia in phase (CML-CP). Asciminib (ASC) is the first BCR::ABL1 inhibitor that Specifically Targets ABL Myristoyl Pocket (STAMP), approved adults newly diagnosed or previously treated CML-CP. The Ib/II, multi-center, open-label ASC4Kids study (NCT04925479) aims identify...
Hematopoietic cell transplantation (HCT) is established as a curative treatment for severe chronic granulomatous disease (CGD). However, outcomes of HCT CGD in Japan had not been precisely reported. We evaluated the outcome by means nationwide survey. A total 91 patients (86 males and 5 females) with who received between 1992 2013 was investigated. Their median age at 11 years (0-39). Sixty-four X-linked caused CYBB gene mutations, 13 autosomal recessive (7 CYBA 6 NCF2), 14 were genetically...
Chronic active Epstein-Barr virus (EBV) infection (CAEBV) is an EBV-associated lymphoproliferative disease characterized by repeated or sustainable infectious mononucleosis (IM)-like symptoms. EBV usually detected in B cells patients who have IM Burkitt's lymphoma and even with X-linked syndrome, which confirmed to vulnerability infection. In contrast, infects T (CD4+ T, CD8+ γδT) NK mono- oligoclonally CAEBV patients. It known that the phenotypes differ depending on are infected EBV....
Objective Kawasaki disease (KD) is a systemic vasculitis in childhood that can lead to coronary artery lesions (CALs). Although early diagnosis and treatment important for preventing KD patients from development of CALs, depends on the clinical features KD. We studied usefulness leucine-rich alpha-2-glycoprotein 1 (LRG1) angiotensinogen (AGT), previously reported as KD-related proteins, estimation intravenous immunoglobulin (IVIG) efficacy. Methods undertook prospective cohort study with...
Abstract Human herpesvirus‐6 (HHV‐6) is a common pathogen affecting the human population. Primary HHV‐6 infection generally occurs during infancy and causes exanthema subitum. Moreover, may exhibit inherited chromosomally integrated (iciHHV‐6) in certain individuals. Although iciHHV‐6 known to be nonpathogenic, it cause reactivation patients with primary immunodeficiency disease (PID). XIAP deficiency rare PID characterized by recurrent hemophagocytic lymphohistiocytosis (HLH). It has been...
Abstract Idiopathic pneumonia syndrome (IPS) is an acute lung complication observed after the early posthematopoietic stem cell transplantation (HSCT) period. Ruxolitinib was effective for a patient with myelodysplastic who developed severe IPS second HSCT. No adverse effects were observed. may be alternative choice HSCT‐related IPS.
Myeloid/natural killer (NK) cell precursor acute leukemia (MNKPL) has been described on the basis of its unique immunophenotype and clinical phenotype. However, there is no consensus characteristics for identifying this disease type because rarity lack defined distinctive molecular characteristics. In study, multiomics analysis revealed that MNKPL distinct from myeloid leukemia, T lymphoblastic mixed-phenotype (MPAL),