A5079998695- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Childhood Cancer Survivors' Quality of Life
- Chronic Myeloid Leukemia Treatments
- Renal and related cancers
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Chronic Lymphocytic Leukemia Research
- Polyomavirus and related diseases
- Neuroblastoma Research and Treatments
- Immunotherapy and Immune Responses
- Viral-associated cancers and disorders
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- CAR-T cell therapy research
- Parvovirus B19 Infection Studies
- Cancer-related gene regulation
- Cytomegalovirus and herpesvirus research
- Glioma Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- RNA Interference and Gene Delivery
Osaka International Cancer Institute
2021-2025
Osaka University
2015-2024
Osaka Health Science University
2009-2023
Osaka University Hospital
2005-2021
Sapporo Hokuyu Hospital
2020
Osaka Prefecture University
2019
Kobe University
2019
Nagoya Medical Center
2018
National Hospital Organization
2018
Japan Pediatric Society
2016
Recent studies revealed that a substantial proportion of patients with high-risk B-cell precursor acute lymphoblastic leukemia (BCP-ALL) harbor fusions involving tyrosine kinase and cytokine receptors, such as ABL1, PDGFRB, JAK2 CRLF2, which are targeted by inhibitors (TKIs). In the present study, transcriptome analysis or multiplex reverse transcriptase-PCR 373 BCP-ALL without recurrent genetic abnormalities identified 29 fusions. Clinically, male predominance (male/female: 22/7), older age...
Abstract Genetic alterations of Ikaros family zinc finger protein 1 ( IKZF ), point mutations in Janus kinase 2 JAK and overexpression cytokine receptor‐like factor CRLF ) were recently reported to be associated with poor outcomes pediatric B‐cell precursor BCP )‐ ALL . Herein, we conducted genetic analyses deletion, mutation exon 16, 17, 21, expression, the presence P2 RY 8‐ fusion F232C 202 ‐ patients newly diagnosed registered Japan Childhood Leukemia Study 02 protocol find out if these...
Abstract Recent genetic studies using high-throughput sequencing have disclosed alterations in B-cell precursor acute lymphoblastic leukemia (B-ALL). However, their effects on clinical outcomes not been fully investigated. To address this, we comprehensively examined and prognostic impact a large series of pediatric B-ALL cases. We performed targeted capture total 1003 patients with from 2 Japanese cohorts. Transcriptome (n = 116) and/or array-based gene expression analysis 120) were also...
Abstract Anti-human leukocyte antigen (HLA) antibodies, particularly donor-specific HLA antibodies (DSA), negatively impact engraftment in hematopoietic cell transplantation. Past studies have proposed various interventions to reduce DSA, but these were primarily from single centers and not large-scale registry data. Therefore, we conducted a retrospective analysis of nationwide data examine the effects anti-HLA on engraftment. Evaluable patients classified into an antibody-negative group (...
Abstract The impact of center volume on outcomes in pediatric hematopoietic cell transplantation (HCT) is not well established. We retrospectively analyzed data from a nationwide registry, including 6966 patients who underwent their first allogeneic HCT at 123 centers Japan between 2001 and 2020. Centers were categorized by transplant as low (C1, the smallest number transplantation), medium-low (C2), medium-high (C3), high (C4, greatest compared across these categories. analysis revealed no...
Wilms tumor gene (WT1) can be overexpressed in childhood cancers. We evaluated the efficacy of WT1 vaccination for five children with solid cancer or acute leukemia. vaccine was administered to HLA-A*2402-positive patients WT1-overexpressing residual despite prior conventional treatment. One patient showed complete response and one stable disease according Response Evaluation Criteria Solid Tumors; remaining three progressive disease. Treatment-related adverse effects were limited local...
This study was a second multicenter trial on childhood ALL by the Japan Childhood Leukemia Study Group (JACLS) to improve outcomes in non-T ALL. Between April 2002 and March 2008, 1138 children with were enrolled JACLS ALL-02 trial. Patients stratified into three groups using age, white blood cell count, unfavorable genetic abnormalities, treatment response: standard risk (SR), high (HR), extremely (ER). Prophylactic cranial radiation therapy (PCRT) abolished except for CNS leukemia....
Abstract Previously, we constructed a recombinant Bifidobacterium longum displaying partial mouse Wilms' tumor 1 (WT1) protein (B. 420) as an oral cancer vaccine using bacterial vector and demonstrated that administration of B. 420 significantly inhibited growth compared with the Db126 WT1 peptide in TRAMP-C2, castration-resistant prostate (CRPC) syngeneic model. The present study 1.0×109 colony-forming units induced higher cytotoxicity against TRAMP-C2 cells than intraperitoneal injection...
The JCCG ALL-B12 clinical trial aimed to evaluate the effectiveness of unvalidated treatment phases for pediatric ALL and develop a safety-focused framework.