A5101935492- Multiple and Secondary Primary Cancers
- Neurogenesis and neuroplasticity mechanisms
- Retinal Development and Disorders
- Lung Cancer Treatments and Mutations
- Acute Myeloid Leukemia Research
- Lung Cancer Research Studies
- Extracellular vesicles in disease
- Hematopoietic Stem Cell Transplantation
- Multiple Myeloma Research and Treatments
- Nicotinic Acetylcholine Receptors Study
- MicroRNA in disease regulation
- Barrier Structure and Function Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Memory and Neural Mechanisms
- Chemokine receptors and signaling
- Neurotransmitter Receptor Influence on Behavior
University of California, Irvine
2020
Memorial Sloan Kettering Cancer Center
2017-2020
Abstract Background Plerixafor, a reversible CXCR4 antagonist, inhibits interactions between leukemic blasts and the bone marrow stromal microenvironment may enhance chemosensitivity. A phase 1 trial of plerixafor in combination with intensive chemotherapy children young adults relapsed or refractory acute lymphoblastic leukemia (ALL), myeloid (AML), myelodysplastic syndrome (MDS) was performed to determine tolerable biologically active dose. Procedure Plerixafor administered daily for 5...
Abstract Maladaptive stress-related behaviors are integral to multiple complex psychiatric disorders, and it has been well established that serotonergic signaling mediates various aspects of these maladaptive states. In studies, we sought uncover the function a previously undefined pathway, which projects from interpeduncular nucleus (IPN) ventral hippocampus (vHipp). Intersectional retrograde chemogenetic viral manipulation strategies were employed manipulate IPN-vHipp pathway during...
The choroid plexus consists of a network secretory epithelial cells localized throughout the lateral, third and fourth ventricles brain.Cerebrospinal fluid (CSF) is generated by released into ventricular environment.This biofluid contains an enriched source proteins, ions, other signaling molecules for extracellular support neurons glial within central nervous system.Given that in brain also release factors CSF, vitro investigations function are necessary to isolate processes selectively...