A5100655727- Chemokine receptors and signaling
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Health disparities and outcomes
- Climate Change and Health Impacts
- Air Quality and Health Impacts
- Cell Adhesion Molecules Research
- Mosquito-borne diseases and control
- Platelet Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Neuroscience and Neuropharmacology Research
- Immune Response and Inflammation
- Galectins and Cancer Biology
- Global Maternal and Child Health
- Plant Virus Research Studies
- interferon and immune responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Sleep and related disorders
- Traditional Chinese Medicine Analysis
- Maternal and Perinatal Health Interventions
- Essential Oils and Antimicrobial Activity
- Esophageal Cancer Research and Treatment
- Malaria Research and Control
- Plant chemical constituents analysis
- Coleoptera Taxonomy and Distribution
University of Electronic Science and Technology of China
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2022-2023
North China University of Science and Technology
2022
North China University of Technology
2022
Hebei General Hospital
2021-2022
Tianjin Meteorological Bureau
2022
Xuzhou University of Technology
2017
Jiangsu Normal University
2017
National Institute of Allergy and Infectious Diseases
1997-2015
Human interferon-inducible protein 10 (IP-10), a member of the alpha chemokine family, inhibits bone marrow colony formation, has antitumor activity in vivo, is chemoattractant for human monocytes and T cells, promotes cell adhesion to endothelial cells. Here we report that IP-10 potent inhibitor angiogenesis vivo. profoundly inhibited basic fibroblast growth factor-induced neovascularization Matrigel (prepared by H. K. Kleinman) injected subcutaneously into athymic mice. In addition, IP-10,...
Abstract CC-chemokine receptor (CCR) 6 is the only known for macrophage inflammatory protein (MIP)-3α, a CC chemokine chemotactic lymphocytes and dendritic cells. Using anti-serum that we raised against N-terminal residues of CCR6, have characterized surface expression CCR6 on peripheral blood leukocytes correlated with responses to MIP-3α. We found was expressed memory T cells, including most α4β7 cells cutaneous lymphocyte-associated Ag-expressing B Accordingly, chemotaxis MIP-3α limited...
Expression of a dominant negative mutant IFNgammaR1 in murine SCK and K1735 tumor cells rendered them relatively unresponsive to IFNgamma vitro more tumorigenic less responsive IL-12 therapy vivo. induced histologic evidence ischemic damage only IFNgamma-responsive tumors, vivo Matrigel vascularization assays revealed that while -unresponsive angiogenesis equally well, its downstream mediator inhibited by the cells. inhibitory activity cells, which may be attributable production chemokine...
Abstract To address the issues of redundancy and specificity chemokines their receptors in lymphocyte biology, we investigated expression CC chemokine CCR1, CCR2, CCR3, CCR5, CXCR3, CXCR4 responses to ligands on memory naive, CD4 CD8 human T cells, both freshly isolated after short term activation vitro. Activation through CD3 for 3 days had most dramatic effects which was up-regulated functional all cell populations including naive cells. In contrast, other modest, CCR5 cells restricted...
Abstract Monokine induced by IFN-γ (MIG), IFN-inducible T cell α chemoattractant (I-TAC), and IFN-γ-inducible protein of 10 kDa (IP-10) are related members the CXC chemokine subfamily that bind to a common receptor, CXCR3, produced different types in response IFN-γ. We have recently reported human polymorphonuclear neutrophils (PMN) capacity release IP-10. Herein, we show PMN also ability produce MIG express I-TAC mRNA combination with either TNF-α or LPS. While IFN-γ, alone association...
During the inflammatory response, adhesion molecule PECAM plays a crucial role in transendothelial migration, passage of leukocytes across endothelium. We report here an additional for subsequent migration monocytes through subendothelial extracellular matrix. has six immunoglobulin (Ig) superfamily domains. Monoclonal antibodies whose epitopes map to domains 1 and/or 2 selectively block monocyte endothelial junction, whereas those that domain 6 only matrix, trapping between endothelium and...
The inflammatory response involves sequential adhesive interactions between cell adhesion molecules of leukocytes and the endothelium. Unlike several steps that precede it, transendothelial migration (diapedesis), step in which migrate apposed endothelial cells, appears to involve primarily one molecule, platelet-endothelial molecule (PECAM, CD31). Therefore, we have focused on PECAM as a target for antiinflammatory therapy. We demonstrate soluble chimeras made entire extracellular portion...
The mechanisms by which interleukin-12 (IL-12) exerts antitumor effects have been difficult to dissect. In this study, we examined the potential contribution of chemokines interferon-gamma-inducible protein-10 (IP-10) and Mig IL-12. Using an athymic mouse model, local inoculations with IL-12 consistently produced tumor size reductions associated characteristic necrosis vascular damage. These were indistinguishable from those IP-10 or injected locally in same model. Local systemic treatment...
Monokine induced by IFN-gamma (Mig; CXC chemokine ligand 9) is an IFN-gamma-inducible that signals through the receptor CXCR3 and known to function as a chemotactic factor for human T cells, particularly following cell activation. The mig gene can be in multiple types organs, Mig has been shown contribute infiltration into immune/inflammatory reactions peripheral tissues mice. We have investigated expression activities of mouse cells role models host defense Murine (Mu)Mig functioned resting...
γ-Secretase, which is responsible for the intramembranous cleavage of Alzheimer β-amyloid precursor protein and signaling receptor Notch, a multiprotein complex consisting at least four components: presenilin (PS); nicastrin (Nct); APH-1 (anterior pharynx-defective-1); enhancer-2 (PEN-2). Presenilin 1 (PS1) known to be essential stability, interaction, trafficking other PS1/γ-secretase components. However, precise functions components remain elusive. Here, we investigated Nct within complex....
CCR6 is the only known receptor for chemokine macrophage-inflammatory protein (MIP)-3alpha/CC ligand (CCL)20. We have shown previously that expressed on peripheral blood B cells, but activity these cells low in vitro assays. report MIP-3alpha/CCL20-induced calcium flux and chemotaxis can be enhanced significantly tonsillar after activation by cross-linking surface Ag receptors. Of particular interest fact was not associated with an increase expression as assessed levels of mRNA, staining, or...
Treatment of murine splenic B lymphocytes and certain B-lineage cell lines with mitogen (LPS) the lymphokine IL-4 has been shown to induce expression germ-line epsilon transcripts (l transcripts) class switching C gene. Three protein complexes, one which (complex 3) is constitutively expressed, have bind a 179-base pair LPS/IL-4-responsive l promoter (Rothman, P., S. C. Li, B. Gorham, L. Glimcher, F. W. Alt, M. Boothby. 1991. Mol. Cell. Biol. 11:5551). Complex 3 indispensable for this...
The slow kinetic efficiency of the cathode oxygen reduction reaction (ORR) and high catalyst cost fuel cells has seriously hindered development clean energy technologies. Herein, a novel...
Most spatial models include a weights matrix (W) derived from the first law of geography to adjust dependence fulfill independence assumption. In various fields such as epidemiological and environmental studies, often shows clustering (or geographic discontinuity) due natural or social factors. cases, adjustment using first-law-of-geography-based W might be inappropriate leads inaccuracy estimations loss statistical power. this work, we propose series data-driven Ws (DDWs) built following...
Stock market volatility was commonly considered as a psychological stressor. However, the association between stock and severe mental disorders (SMD) has not been investigated. Daily numbers of SMD hospital admissions Shanghai Exchange Composite (SSEC) Index in 7 cities southwestern China from 2020 to 2023 were collected. A two-stage time-series analysis conducted reveal risk admission for SMD. Stratified analyses performed by age, gender, ICD-10 codes explore potential high-risk groups. The...
The CC chemokine macrophage inflammatory protein-3alpha (MIP-3alpha) is the product of recent electronic cloning efforts, however, little characterization its spectrum biological effects has been undertaken. Human eosinophils exhibited pertussis-toxin-sensitive migration in response to human recombinant (hr)MIP-3alpha. Messenger RNA for MIP-3alpha receptor, CCR-6, and low levels surface expression were demonstrated by reverse transcriptase-polymerase chain reaction FACS analysis. Analyses...
Platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31), expressed on the surfaces of leukocytes and concentrated in junctions between endothelial cells plays an important role transendothelial migration neutrophils monocytes. Soluble recombinant PECAM-IgG injected i.v. into mice blocks acute leukocyte emigration by 80%. To study PECAM models chronic inflammation, we generated transgenic constitutively expressing soluble full-length murine as IgG chimera. Three founder lines this...
CXCR6, the receptor for CXCL16, is expressed on multiple cell types and can be a coreceptor human immunodeficiency virus 1. Except all chemokine receptors contain D<sup>3.49</sup>R<sup>3.50</sup>Y<sup>3.51</sup> sequence, but two A<sup>3.53</sup> at cytoplasmic terminus of third transmembrane helix (H3C), region within class A G protein–coupled that contacts proteins. In H3C contains D<sup>3.49</sup>R<sup>3.50</sup>F<sup>3.51</sup>I<sup>3.52</sup>V<sup>3.53</sup> positions 126–130. We...