A5051923580- Advanced Photocatalysis Techniques
- RNA modifications and cancer
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- Innovations in Medical Education
- Lung Cancer Diagnosis and Treatment
- Perovskite Materials and Applications
- Circular RNAs in diseases
- Chalcogenide Semiconductor Thin Films
- Copper-based nanomaterials and applications
- Epigenetics and DNA Methylation
- Gold and Silver Nanoparticles Synthesis and Applications
- MXene and MAX Phase Materials
- Biomedical and Engineering Education
- Diabetes and associated disorders
- Lung Cancer Treatments and Mutations
- Pancreatic function and diabetes
- Advanced Nanomaterials in Catalysis
- Colorectal and Anal Carcinomas
- Autophagy in Disease and Therapy
- Peptidase Inhibition and Analysis
- Health and Medical Research Impacts
- Medical Education and Admissions
- Covalent Organic Framework Applications
- Xenotransplantation and immune response
Yunnan University
2024
Shantou University
2020-2023
Guangdong Provincial People's Hospital
2021-2023
Guangdong Academy of Medical Sciences
2021-2023
Southern Medical University
2021-2023
Shantou University Medical College
2022-2023
South China University of Technology
2021
The abnormal activation of epidermal growth factor receptor (EGFR) drives the development non-small cell lung cancer (NSCLC). EGFR-targeting tyrosine kinase inhibitor osimertinib is frequently used to clinically treat NSCLC and exhibits marked efficacy in patients with who have an EGFR mutation. However, free administration inadequate response vivo, only ∼3% demonstrating a complete clinical response. Consequently, we designed biomimetic nanoparticle (CMNP@Osi) comprising polymeric core...
Background The predictive efficacy of current biomarker immune checkpoint inhibitors (ICIs) is not sufficient. This study investigated the causality between radiomic biomarkers and immunotherapy response status in patients with stage IB–IV non-small cell lung cancer (NSCLC), including its biological context for ICIs treatment prediction. Methods CT images from 319 pretreatment NSCLC receiving January 2015 November 2021 were retrospectively collected composed a discovery (n=214), independent...
Autophagy, a key regulator of programmed cell death, is critical for maintaining the stability intracellular environment. Increasing evidence has revealed clinical importance interactions between autophagy and immune status in lung adenocarcinoma. The present study evaluated potential autophagy-immune-derived biomarkers to predict prognosis therapeutic response patients with Patients from GSE72094 dataset were randomized 7:3 training set an internal validation set. Three independent cohorts,...
Presently, a variety of policies and measures has implemented to enhance the scientific research innovation ability medical students, but in process practice, there are many problems, such as they lack independent topic selection ability, weak skills, autonomous learning results simple ineffective, limited teacher guidance time so on. This paper attempted build an effective model for promotion students' order establish efficacy evaluation "Medical Innovative Scientific Research Program."...
To validate a competency-based assessment scale for students majoring in clinical medicine, ASK-SEAT. Students' competency growth across grade years was also examined trends and gaps.Questionnaires were distributed online from May through August 2018 to Year-2 Year-6 who majored medicine at the Shantou University Medical College (China). Cronbach alpha values calculated reliability of scale, exploratory factor analysis employed structural validity. Predictive validity explored by correlating...
Abstract Chromatin accessibility is a crucial epigenetic concept that plays biological role in oncology. As humans become more involved cancer research, comprehensive database required to identify and annotate tumor chromatin accessible regions (CARs). Here, CATA was developed provide cancer-related CAR annotation. Currently, possesses 2,991,163 CARs, relevant clinical data, transcription factor binding predictions for CARs from 410 samples of 24 types. Furthermore, were annotated by SNPs,...
Long non-coding RNAs (lncRNAs) participate in the regulation of immune response and carcinogenesis, shaping tumor microenvironment, which could be utilized construction prognostic signatures for non-small cell lung cancer (NSCLC) as supplements. Data patients with stage I-III NSCLC was downloaded from online databases. The least absolute shrinkage selection operator used to construct a lncRNA-based model. Differences microenvironments pathways were explored high-risk low-risk groups,...
3068 Background: Pathological subtypes associate with surgical strategies of pulmonary nodule, during which thoracic surgeons make decision through intraoperative frozen resection diagnosis. However, section is time-consuming, vague and maybe misleading due to the limited sample subjective judgements from pathologists. This study developed a predictive deep neural network for pathological invasiveness nodules based on images gross specimens. Methods: We prospectively collected specimen image...
e13577 Background: Histopathological classification of operable early-stage lung adenocarcinoma may influence the intraoperative surgical decision and postoperative management for patients. However, it is difficult to comprehensively evaluate grade risk based on preoperative CT imaging alone. Therefore, we aimed establish a pathological grading model patients with pulmonary nodules through imaging. Methods: This was diagnostic, retrospective, multi-centric study conducted in two independent...