A5027179401- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Traditional Chinese Medicine Studies
- Hepatitis C virus research
- Gut microbiota and health
- Hepatocellular Carcinoma Treatment and Prognosis
- Acupuncture Treatment Research Studies
- Ideological and Political Education
- Cell death mechanisms and regulation
- Hepatitis Viruses Studies and Epidemiology
- Diet, Metabolism, and Disease
- Immunotherapy and Immune Responses
- Alcohol Consumption and Health Effects
- Birth, Development, and Health
- Lipid metabolism and disorders
- NF-κB Signaling Pathways
- Neonatal Respiratory Health Research
- Liver physiology and pathology
- Immune Cell Function and Interaction
- Artificial Intelligence in Healthcare
- Endoplasmic Reticulum Stress and Disease
- Healthcare and Venom Research
- Liver Disease and Transplantation
- Congenital Diaphragmatic Hernia Studies
Guangzhou University of Chinese Medicine
2019-2025
Foshan Hospital of TCM
2004-2025
Affiliated Hospital of Southwest Medical University
2018
Guangzhou University
2011
Shanghai University of Traditional Chinese Medicine
2008
Traditional Chinese Medicine Hospital of Kunshan
2008
Shandong University of Traditional Chinese Medicine
2006
Nucleotide analogs treatment can reverse liver fibrosis in chronic hepatitis B (CHB). However, it has limited effect on resolution patients with CHB, particularly preventing progression to hepatocellular carcinoma (HCC). Ruangan granule (RG), a Chinese herbal formula, proven produce therapeutic against animal experiment. Thus, we aimed evaluate the of our formula (RG) combined entecavir (ETV) advanced fibrosis/early cirrhosis from CHB. A total 240 CHB histologically confirmed 12 centers were...
Background NASH-associated liver cancer (NALC) is a significant contributor to global mortality, closely linked the increasing prevalence of non-alcoholic fatty disease (NAFLD) and steatohepatitis (NASH). This study comprehensively examines burden NALC from 1990 2021. Methods used data Global Burden Disease (GBD) 2021 database analyze death age-standardized rates (ASDR) globally regionally We applied Joinpoint regression analysis assess temporal trends, calculating annual percent change...
Noninvasive diagnostic technologies that can dynamically monitor changes in liver inflammation are highly important for the management of chronic hepatitis B (CHB) patients and thus warrant further exploration. This study assessed efficacy FibroScan CHB patients.A total 1185 were selected, ultrasound-guided biopsy was performed within 1 month after test. The stiffness measurement (LSM), reliability criteria (IQR/M) LSM, quality (complete portal area, PA), grades main observation items this...
Targeting the gut microbiota is an emerging strategy to treat nonalcoholic fatty liver disease (NAFLD). Nonetheless, causal relationship between specific and NAFLD remains unclear. We first obtained genome-wide association study statistics on from publicly available databases. then performed Mendelian randomization (MR) analysis determine potential by 5 different methods, conducted a series of sensitivity analyses validate robustness MR results. Furthermore, we investigated direction...
A20 is a powerful suppressor for inflammatory response. This study aims to determine level in patients with chronic hepatitis B (CHB), and analyze its association the disease severity. The role of response was further investigated vivo vitro. Our results showed significantly higher both serum liver tissues CHB than health controls. Serum positively correlated ALT, AST TNF-α. To induce inflammation injury, mice were injected intraperitoneally D-galactosamine (D-GalN), resulting rapid increase...
Objective. To investigate the dendritic cells (DCs) maturity differences of HBeAg negative chronic hepatitis B (CHB) patients with different spleen deficiency (SD) syndromes and explore role syndrome differentiation in therapeutic evaluation Chinese medicine. Methods. 120 participants were recruited including three treatment groups SD categories as liver depression (SDLD), damp heat (SDDH), kidney (SDKD) one healthy control group; each group had 30 participants. Corresponding drugs applied....
No guideline recommends antiviral therapy for hepatitis B e antigen (HBeAg)-positive chronic patients with persistently normal alanine aminotransferase levels and a high virus (HBV) DNA viral load.To evaluate the feasibility safety of Chinese herbal formula as therapeutic option HBV infection.In total, 395 (30-65 years old) confirmed HBeAg-positive infection were randomized to receive either or placebo 96 wk. Endpoints efficacy included: (1) decreased less than 4 log10 IU/mL at weeks 48 96;...
Rationale: Idiopathic noncirrhotic portal hypertension (INCPH) is a rare liver disorder with elevated pressure without cirrhosis, making diagnosis challenging. This case report presents 46-year-old Chinese male INCPH, highlighting the crucial role of biopsy. Patient concerns: A presented persistent fatigue that lasted for 2 months and significantly worsened over last 3 days. The patient described his as profound lack energy persisted throughout day, which progressively impaired ability to...
Abstract Background: To explore the potential biological characteristics of traditional Chinese medicine(TCM) syndromes in CHB patients is great significance to improve level TCM treatment.This study was designed gut microbiota with two most common Syndromes. Methods: According diagnostic criteria Western medicine, and screening exclusion criteria, 65 cases damp heat syndrome 28 liver depression spleen deficiency were finally included study. All basic information gathered fresh fecal samples...
Prenatal glucocorticoids(GC) therapy can effectively reduce neonatal mortality and the incidence of severe diseases without increasing risk chorioamnionitis, endometritis maternal death, it has become one most important prenatal interventions to improve prognosis.Chinese guideline points out that all pregnant women at preterm birth between 28 34+ 6 weeks should be treated with a courses GC recent studies show also considered 22-39 if clinical needs.Prenatal use does not increase developing...
Background: It is important for clinical diagnosis and therapeutic effect monitoring of chronic hepatitis B(CHB) to evaluate liver inflammation by noninvasive method. Fibroscan based on the transient elastography (TE) techniques a method widely used in evaluation fibrosis. We aimed assess efficacy patients with CHB. Methods: Ultrasound-guided biopsy was completed within one month after FibroScan testing 1,185 CHB patients.The reliability criteria detection are as follows:ratio interquartile...
Background: It is important for chronic hepatitis B(CHB) to evaluate liver inflammation by noninvasive method. Fibroscan based on the transient elastography (TE) techniques a method widely used in evaluation of fibrosis. We aimed assess efficacy diagnosis patients with CHB.Methods: Ultrasound-guided biopsy was completed within one month after FibroScan testing 1,185 CHB patients. Both reliability criteria( interquartile range median,IQR/M) and quality biopsy(complete portal tracts, CPTs)...
Abstract Background: To explore the potential biological characteristics of traditional Chinese medicine(TCM) syndromes in CHB patients is great significance to improve level TCM treatment.This study was designed gut microbiota with two most common Syndromes. Methods: According diagnostic criteria Western medicine, and screening exclusion criteria, 65 cases damp heat syndrome 28 liver depression spleen deficiency were finally included study. All basic information gathered fresh fecal samples...
The kinds of special prescriptions in the book Chengfang Qieyong cover a wide range subjects such as internal medicine, gynecology, pediatrics and surgery, etc. These have gathered original discussions doctors all ages, condensed author's own in-depth insights, displayed profound connotation traditional Chinese medicine or clinical efficacy characteristics. Guided by function categories monograph, 26 were integrated into seven categories, i.e.treating Qi regulating Blood, nourishing...
Abstract Background: Noninvasive diagnostic technologies that can dynamically monitor changes in liver inflammation are highly important for the management of chronic hepatitis B (CHB) patients and thus warrant further exploration. This study assessed efficacy FibroScan CHB patients. Methods: A total 1185 were selected, ultrasound-guided biopsy was performed within one month after test. The stiffness measurement (LSM), reliability criteria (IQR/M) LSM, quality (complete portal area, PA),...