A5103065528- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- RNA Research and Splicing
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Fractional Differential Equations Solutions
- Gut microbiota and health
- Mesenchymal stem cell research
- Numerical methods in engineering
- Cancer Cells and Metastasis
- Environmental Changes in China
- Artificial Intelligence in Healthcare and Education
- Environmental Quality and Pollution
- Peptidase Inhibition and Analysis
- Influenza Virus Research Studies
- Gender Roles and Identity Studies
- Ethics in Business and Education
- Ideological and Political Education
- China's Ethnic Minorities and Relations
- Social Capital and Networks
- Extracellular vesicles in disease
- Social Power and Status Dynamics
Peking Union Medical College Hospital
2013-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2023
Guangxi Medical University
2019-2022
Weatherford College
2021
Beijing Hua Xin Hospital
2021
Tumor Hospital of Guangxi Medical University
2016-2019
Research Institute of Petroleum Exploration and Development
2018
Czech Academy of Sciences, Institute of Geophysics
2018
Harbin Medical University
2013
Second Affiliated Hospital of Harbin Medical University
2013
Artificial intelligence (AI) is rapidly being applied to a wide range of fields, including medicine, and has been considered as an approach that may augment or substitute human professionals in primary healthcare.However, AI also raises several challenges ethical concerns.In this article, the author investigates discusses three aspects medicine healthcare: application promises AI, special concerns pertaining some frontier suggestive governance systems.Despite great potentials research...
// Hui Zhang 1,* , Huanwen Wu Jian Guan 2 Li Wang 1 Xinyu Ren Xiaohua Shi Zhiyong Liang and Tonghua Liu Department of Pathology, Peking Union Medical College Hospital, Chinese Academy Science, Beijing, PR China Cancer Institute Sciences, * These authors contributed equally to this work Correspondence: Liu, email: Liang, Keywords : Pancreatic cancer, stellate cells, Chemoresistance, SDF-1α, IL-6 Received November 23, 2014 Accepted December 25, Published 30, Abstract cancer exhibits the...
Background: PLK1, a typical PLK protein, is the main driver of cancer cell growth and proliferation. It an inhibitor protein kinases that currently being investigated in clinical studies. often used as tumor marker, high PLK1 expression correlates with poor prognosis cancer. Overexpression MYC hallmark many human cancers. modulates transcription thousands genes required to coordinate series cellular processes, including those essential for growth, proliferation, differentiation, self-renewal...
Caveolin-1 (CAV-1), which is an oncoprotein and a tumor suppressor, highly expressed in normal osteoblasts. Although researchers have investigated its role human osteosarcoma, the mechanism of caveolin-1 action osteosarcoma remains unknown. In present study, Saos-2 U-2 OS cells were cultured with continuous induction protocol gradually increasing Taxol concentration for 6 months to establish drug-resistant cell lines. CAV-1 expression levels detected via western blotting quantitative...
Accumulating evidence demonstrates that complex diseases may arise from cooperative effects of multiple dysfunctional miRNAs. Thus, identifying abnormal functions cooperatively regulated by miRNAs is useful for understanding the pathogenesis diseases. In this study, we proposed a multistep method to identify miRNA-mRNA regulatory modules (dMiMRMs) in specific disease, which group regulate target genes involved function. We identified miRNAs, were differentially expressed and inversely most...
To investigate the protective effect of Exosomes from human adipose-derived mesenchymal stem cells (hAMSCs) in neural injury induced by glutamate and its possible mechanism.Characteristics hAMSCs were identified electron microscopy Western blot analysis. Cytokines that might play a major role tested enzyme-linked immunosorbent assay (ELISA). The action Exosome signaling pathway researched vitro glutamate, including control group (without Glu), Glu (dealing with Glu+Exo +100 ng/ml Exo),...
Purpose: The long noncoding RNA CCDC144NL antisense 1 (CCDC144NL-AS1) exhibits important functions in gastric cancer. In this study, we aimed to investigate the roles of CCDC144NL-AS1 modulating phenotype osteosarcoma (OS) cells vitro and vivo elucidate its underlying mechanisms. Methods: Reverse transcription quantitative polymerase chain reaction (PCR) was performed determine expression level OS tissues cell lines. proliferation, apoptosis, migration, invasion as well tumor growth were...
Anoikis resistance is a crucial step in the process of tumor metastasis. This determines whether cells will survive when they become detached from extracellular matrix. However, specific mechanism to bypass anoikis and resistant remains be elucidated. The present study aimed determine internal bypassing through comparison human osteosarcoma cell lines with normal lines. High activating transcription factor 4 (ATF4) myelocytomatosis oncogene (MYC) expression levels were observed MG‑63 U‑2 OS...
Melanoma is a highly malignant skin tumour, and one of the most rapidly growing tumors in recent years. According to statistics, morbidity cancer increases with age, accounting for 1.6% new cases 0.6% deaths worldwide. has serious impact on society families, thus it great significance find biological markers related diagnosis treatment melanoma.To explore expression predictive value mir-489 mir-21 melanoma metastasis.A total 60 patients treated at our hospital from June 2017 December 2018...
Autophagy is closely related to skin cutaneous melanoma (SKCM), but the mechanism involved unclear. Therefore, exploration of role autophagy-related genes (ARGs) in SKCM necessary.Differential expression (DEARGs) were first analysed. Univariate and multivariate Cox regression analyses used evaluate DEARGs prognosis SKCM. Further, levels prognosis-related verified by immunohistochemical (IHC) staining. Finally, gene set enrichment analysis (GSEA) was explore underlying molecular mechanisms...
This paper examines the fundamental theoretical approaches and research interests of Peter M. Blau by focusing upon three distinct stages in his work: exchange theory, status attainment macrostructural theory. A discussion four general issues reveals various continuities transitions these analytical strategies. The features examined are (a) social stratification, (b) investigative strategies, (c) focus assumptions, (d) micro/macro units analysis. It is argued that rest different conceptions...
Background: The objective of this study was to compare the effects simple-bundles management and guideline-bundles on elderly patients with severe sepsis septic shock.Methods: This a single-center retrospective observational hospital discharge diagnosis or shock from First Hospital Tsinghua University January 2014 December 2018. Management for emergency ward adhered simple bundles. intensive care unit Surviving Sepsis Campaign Guidelines 2012. Data two groups were collected determine...
One of the salient developments in North America’s direct selling industry is increasing diversity both distributor and clientele base. It has been frequently noted that organizations comprised certain ethnic minorities have exceptional terms stability growth contrast to industry’s reputation for a high turnover rate. Focusing on led by entrepreneurs Chinese immigrants, current study employs structural ritualization theory concept reproduction considers organizational leadership practices...
In this study, we determined APT of normal testes possible variations with age, and to assess the feasibility in testicular spermatogenic function evaluation. Our results showed that tissue decrease advancing could be promising evaluation male infertility.
Views Icon Article contents Figures & tables Video Audio Supplementary Data Share Facebook Twitter LinkedIn Email Tools Get Permissions Cite Search Site Citation Guan Jian, John Young; Introduction to the Investigation of Present Situation and Development Ethnic Minorities in China: A Reflection on Changes Last Ten Years Field Anthropology China. Practicing 1 January 2002; 24 (1): 2–5. doi: https://doi.org/10.17730/praa.24.1.kk25828020q8479r Download citation file: Ris (Zotero) Reference...
Background: More and more evidence has shown that non-coding RNA (ncRNA), including long ncRNA (lncRNA) micro (miRNA), plays a crucial regulatory role in osteosarcoma (OS). Previously, we revealed Rho-related coiled coil incorporating protein kinase 1(XIAP). A transfer-related gene is negatively regulated by microRNA-20a-5p (miR-20a-5p) the of oncogene OS. It not clear if any lncRNA involved axial upstream miR-20a-5p/XIAP. Methods: Expression LSINCT5 miR-20a-5p/XIAP OS tissues was determined...
Expression of Concern for the article Long Noncoding RNA CCDC144NL-AS1 Promotes Oncogenicity Osteosarcoma by Acting as a Molecular Sponge microRNA-490-3p and Thereby Increasing HMGA2