A5100762115- Tracheal and airway disorders
- Head and Neck Anomalies
- Hearing, Cochlea, Tinnitus, Genetics
- Vascular Malformations and Hemangiomas
- Voice and Speech Disorders
- High Altitude and Hypoxia
- Salivary Gland Tumors Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Congenital Diaphragmatic Hernia Studies
- Teratomas and Epidermoid Cysts
- Cancer-related molecular mechanisms research
- Mycobacterium research and diagnosis
- Dysphagia Assessment and Management
- Tuberculosis Research and Epidemiology
- Tumors and Oncological Cases
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Connexins and lens biology
- Veterinary Equine Medical Research
- Glycosylation and Glycoproteins Research
- Mesenchymal stem cell research
- Nasal Surgery and Airway Studies
- Myasthenia Gravis and Thymoma
- Ion Channels and Receptors
- Thyroid and Parathyroid Surgery
Shanghai Children's Hospital
2014-2025
Shanghai Jiao Tong University
2016-2025
Qinghai University
2020-2025
Second Affiliated Hospital of Zhejiang University
2025
Chinese PLA General Hospital
2025
Chinese People's Liberation Army
2025
Zhejiang University
2025
Panzhihua University
2024
State Key Laboratory For Conservation and Utilization of Subtropical Agro-Bioresources
2023
Guangxi University
2023
Spondylolysis, often progressing to spondylolisthesis, commonly defies conservative treatment in refractory cases, indicating a need for surgery. Robot-assisted techniques may provide stable and effective minimally invasive approach the of lumbar spondylolysis. To compare clinical efficacy between robot-assisted percutaneous screw fixation combined with endoscopic bone graft conventional open A cohort study involving 43 individuals spondylolysis who underwent surgical was conducted. From...
Cyclic di-GMP (c-di-GMP) is a global signaling molecule that widely modulates diverse cellular processes. However, whether or not the c-di-GMP signal participates in regulation of bacterial antioxidant defense unclear, and involved regulators remain to be explored. In this study, we characterized HpoR as novel effective transcription factor found link between Mycobacterium smegmatis. H2O2 stress induces accumulation M. High level triggers expression redox gene cluster, designated hpoR...
Abstract Abnormal expression of Ten eleven translocation‐2 (Tet2) contributes to the pathogenesis Alzheimer's disease (AD). However, date, role Tet2 in modulating neuronal morphology upon amyloid‐β (Aβ)‐induced neurotoxicity has not been shown a mouse model AD. Here, we have developed injured hippocampal neurons induced by Aβ 42 oligomers vitro. We also investigated using recombinant plasmids‐induced inhibition or over‐expression. found that reduced exacerbated damage, whereas increased was...
Objective:Explore the clinical diagnosis and treatment strategies of recurrent multiple chondritis in children with airway involvement as main cause. Methods:From June 2021 to May 2023, five relapsing polychondritis were admitted our department, all whom met Damiani criteria. Tracheotomy was performed patients. Endoscopy indicated subglottic stenosis, one case classified grade Ⅲ four cases Ⅳ according Myer-Cotton classification. Enhanced CT scans head neck showed fixed lumen narrowing...
Abstract Cell Adhesion Molecules (CAMs) play a crucial role in regulating immune responses and repairing damage caused by hypoxia. However, the relationship between expression characteristics of CAMs yak lung tissues their adaptation to plateau environment remains unclear. To address this question, we compared from yaks cattle at same altitude. After digesting with trypsin or Type I collagenase for varying durations, observed that fewer cells were isolated cattle. RNA sequencing (RNA-seq)...
Ischemic stroke recovery involves dynamic interactions between the central nervous system and infiltrating immune cells. Peripheral cells compete with resident microglia for spatial niches in brain, but how modulating this balance affects remains unclear. Here, we use PLX5622 to create peripheral cells, altering competition male mice following transient middle cerebral artery occlusion (tMCAO). We find that early-phase attenuation promotes long-term functional recovery. This intervention...
Objective:To explore the clinical manifestations, diagnosis, treatment, pathological types and prognosis of primary cervical neuroblastoma in children. Methods:The data 11 children with admitted to Department Otolaryngology Head Neck Surgery at Shanghai Children's Hospital from April 2015 2022 were retrospectively analyzed. The characteristics, imaging findings, types, treatment methods, outcomes these patients examined conjunction a review literature. Results:The cohort ranged age 28 days...
Objective We herein retrospectively analyzed the clinical characteristics and treatment protocols of children with relapsing polychondritis (RP) airway involvement. Methods reviewed medical records eight pediatric-onset RP involvement who presented to Shanghai Children's Hospital from June 2021 2024. All met Damiani's criteria for diagnosis RP. One child underwent “laryngotracheal reconstruction hyoid graft + T-tube implantation bioabsorbable corticosteroid-eluting stent implantation,” while...
Heat stress has a significant negative impact on plant growth, development, and yield. The cell wall, key structural feature that sets plants apart from animals, not only acts as the first physical barrier against heat but also plays an active role in (HS) response through signaling pathways. wall complex composition, including cellulose, hemicellulose, lignin, pectin. These components provide mechanical support for growth constitute material basis to environmental changes. This review...
Collagen is crucial for tissue structure, functional maintenance, and cellular processes such as proliferation differentiation. However, the specific changes in collagen expression its associated genes lung tissues of yaks at high altitudes their relationship with environmental adaptation remain poorly understood. Studying differences content fibers gene between (4,500 m) low (2,600 altitudes, well cattle m). Using Masson staining, we found that fiber altitude was significantly higher...
Meningeal lymphatic vessels (mLVs) play a critical role in clearing erythrocytes from the subarachnoid space and immune cells brain parenchyma following hemorrhage (SAH). However, drainage function of mLVs is impaired during acute stage after SAH gradually recovers subacute phase. We aimed to investigate meningeal transcriptional response post-SAH elucidate dynamic influence microenvironment on function. employed bioinformatics analysis single-cell RNA sequencing spatial transcriptomics...
ABSTRACT Aims Following ischemic stroke, peripheral immune cell infiltration is characterized by myeloid predominance in the acute phase and lymphoid subacute to chronic phases. Endothelial cells, as a critical interface between circulation brain, upregulate adhesion molecules facilitate infiltration. However, it remains unclear whether endothelial cells exhibit functional differences at different stages after stroke how these affect Methods We performed single‐cell RNA sequencing on from...
The Kölliker's organ is a transient epithelial structure during cochlea development that gradually degenerates and disappears at postnatal 12-14 days (P12-14). While apoptosis has been shown to play an essential role in the degeneration of organ, another programmed cell death, autophagy, remains unclear. In our study, autophagy markers including microtubule associated protein light chain 3-II (LC3-II), sequestosome 1 (SQSTM1/p62) Beclin1 were detected supporting cells through...
Ribbon synapses are important structures in transmitting auditory signals from the inner hair cells (IHCs) to their corresponding spiral ganglion neurons (SGNs). Over last few decades, deafness has been primarily attributed deterioration of cochlear rather than ribbon synapses. Hearing dysfunction that cannot be detected by hearing threshold is defined as hidden loss (HHL). The relationship between and FGF22 deletion remains unknown. In this study, we used a 6-week-old knockout mice model...
Background: To reduce surgical complications and avoid lifelong thyroid hormone replacement, hemithyroidectomy is preferred in children adolescents with benign nodular disease. However, hypothyroidism following may occur, postoperative replacement for usually administered without a full understanding of the clinical characteristics hypothyroidism. Methods: investigate incidence risk factors after adolescents, to identify whether necessary, retrospective review 43 patients under 18 years age...
Iatrogenic laryngotracheal stenosis (iLTS) is a pathological condition characterized by the narrowing of laryngeal and tracheal structures due to formation abnormal scar tissue. The core iLTS lies in fibrosis tissue, recent research has unveiled novel discoveries regarding underlying mechanisms fibrosis. This review provides an overview advancements understanding iLTS. It encompasses various aspects, such as immune system dysregulation, changes extracellular matrix (ECM), metabolic...
Autophagy is closely related to skin cutaneous melanoma (SKCM), but the mechanism involved unclear. Therefore, exploration of role autophagy-related genes (ARGs) in SKCM necessary.Differential expression (DEARGs) were first analysed. Univariate and multivariate Cox regression analyses used evaluate DEARGs prognosis SKCM. Further, levels prognosis-related verified by immunohistochemical (IHC) staining. Finally, gene set enrichment analysis (GSEA) was explore underlying molecular mechanisms...