A5101707028- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Traditional Chinese Medicine Analysis
- Cancer Research and Treatments
- RNA Interference and Gene Delivery
- Neurogenesis and neuroplasticity mechanisms
- Muscle Physiology and Disorders
- Alzheimer's disease research and treatments
- Essential Oils and Antimicrobial Activity
- Metabolomics and Mass Spectrometry Studies
- Chromatography in Natural Products
- Phytochemicals and Antioxidant Activities
- Molecular Biology Techniques and Applications
- Traditional Chinese Medicine Studies
- Mesenchymal stem cell research
- Medicinal Plants and Neuroprotection
- Alkaloids: synthesis and pharmacology
- Medicinal Plant Pharmacodynamics Research
- Tea Polyphenols and Effects
- Neurological Disease Mechanisms and Treatments
- RNA modifications and cancer
- Nuts composition and effects
- Pluripotent Stem Cells Research
- Phytochemistry and Bioactivity Studies
- Polysaccharides and Plant Cell Walls
Yunnan Academy of Agricultural Sciences
2015-2025
Gansu Provincial Maternal and Child Health Hospital
2022-2025
Hangzhou Normal University
2025
University of Electronic Science and Technology of China
2023-2024
Southwest Minzu University
2024
Mianyang Central Hospital
2023-2024
Ningbo University
2020-2022
Liaoning University of Traditional Chinese Medicine
2020-2021
West China Medical Center of Sichuan University
1996-2021
Beijing Technology and Business University
2021
The heterogeneous Cu-based solid catalysts have attracted enormous attention of researchers in different potential applications. In this work, a graphitic carbon nitride/copper-doped dots (g-C3N4/Cu-CDs) nanocomposite with both intrinsic peroxidase- and oxidase-like (POD- OXD-like) activities was successfully prepared. Due to the synergistic catalytic enhancement electron transmission provided by g-C3N4, POD- OXD-like g-C3N4/Cu-CDs were significantly improved compared those g-C3N4 Cu-CDs....
Abstract Abnormal expression of Ten eleven translocation‐2 (Tet2) contributes to the pathogenesis Alzheimer's disease (AD). However, date, role Tet2 in modulating neuronal morphology upon amyloid‐β (Aβ)‐induced neurotoxicity has not been shown a mouse model AD. Here, we have developed injured hippocampal neurons induced by Aβ 42 oligomers vitro. We also investigated using recombinant plasmids‐induced inhibition or over‐expression. found that reduced exacerbated damage, whereas increased was...
Abstract BACKGROUND Macamides with a benzylalkylamide nucleus are characteristic and major bioactive compounds in the functional food maca ( Lepidium meyenii Walp). The aim of this study was to explore variations macamide content among from China Peru. Twenty‐seven batches hypocotyls different phenotypes, sampled geographical origins, were extracted profiled by liquid chromatography ultraviolet detection/tandem mass spectrometry (LC‐UV/MS/MS). RESULTS Twelve macamides identified MS operated...
Pistacia weinmannifolia (Anacardiaceae) has been used in herbal medicine for the treatment of influenza, dysentery and enteritis China. It was recently observed that P. root extract (PWRE) exerts anti‑inflammatory effects both vitro vivo models. Based on results from previous studies, present study investigated protective effect PWRE airway inflammation mucus hypersecretion. Treatment with significantly decreased number eosinophils levels Th2 cytokines, such as interleukin (IL)‑4, IL‑5...
Chronic low-grade inflammation (CLGI) is associated with obesity and one of its pathogenetic mechanisms. Lipopolysaccharide (LPS), a component Gram-negative bacterial cell walls, the principal cause CLGI. Studies have found that capsaicin significantly reduces relative abundance LPS-producing bacteria. In present study,
As part of an ongoing search for new anti-inflammatory agents from medicinal plants, five dimeric and trimeric flavonoids (1–5) were isolated the roots Pistacia weinmannifolia. The structures pistachalcone A (1), B (2), pistaflavanone (3), C (4), D (5) elucidated by analysis spectroscopic data. known compounds rhuschalcone II (6), VI (7), pauferrol (8) also identified. Our in vitro found that P. weinmannifolia root extract exert effects phorbol myristate acetate (PMA)-induced NCI-H292 airway...
Achieving the twin objectives of increasing economic efficiency and lowering environmental pollution in agricultural modernization requires regions to increase energy efficiency. This study used DEA-EBM model, an evaluation tool, measure analyze input redundancy 30 Chinese from 2000 2022. It also examined factors that influence these metrics. According findings, China’s varies greatly by region, with eastern region performing at its best western a relatively low level. However, this gap is...
Gentiana rigescens is a rich source of iridoids and commonly used as folk medicine for treatment hepatitis cholecystitis over 1000 years. A rapid ultrafast liquid chromatography-ultraviolet method was developed simultaneous determination four major iridoid glycosides in G. rigescens. Response surface methodology based on the Box-Behnken design applied to optimize extraction conditions glycosides. Using Shim-Pack XR-ODS III, were efficiently separated with an acetonitrile:0.1% formic acid...
Macamides are characteristically found in maca (Lepidium meyenii Walper). Fatty acid derivatives also an important type of constituent maca, since they not only relate to the biosynthesis macamides postharvest process but possess some bioactivities. To study their comprehensive profiles tubers processed via air-drying method, ultraperformance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) analyses were performed identify macamide and fatty molecules. Their...
Acute kidney injury (AKI) is one of the most common clinical emergencies characterized by rapid progression, difficulty in early diagnosis, and high mortality. Currently, there are no effective AKI diagnostic methods treatments. Therefore, identifying new mechanisms have become urgent for development targets diagnosis treatment current setting.In this study, systematic analysis comparison serum metabolic profiles patients, chronic disease (CKD) healthy subjects were performed using...
Pistacia weinmannifolia (PW) has been used in traditional Chinese medicine to treat headaches, dysentery, enteritis and influenza. However, PW not known for treating respiratory inflammatory diseases, including chronic obstructive pulmonary disease (COPD). The present vitro analysis confirmed that root extract (PWRE) exerts anti‑inflammatory effects phorbol myristate acetate‑ or tumor necrosis factor α (TNF‑α)‑stimulated human lung epithelial NCI‑H292 cells by attenuating the expression of...
Gentiana rigescens, an ethnomedicine, is widely cultivated in Yunnan province of China. Although a wide range metabolites including iridoid glycosides, flavonoids and triterpenoids have been reported this the data on accumulation distribution certain parts are limited. In study, targeted metabolic fingerprinting glycosides based liquid chromatography-ultraviolet detection-tandem mass spectrometry (LC-UV-MS/MS) was developed to investigate similarities differences different origins....
Abstract Many species from genus Gentiana (Gentianaceae) have a long history of applications as folk medicines in the world. A simple rapid UPLC‐UV‐MS/MS method has been developed and validated for simultaneous determination six index constituents (gentiopicroside, swertiamarin, loganic acid, sweroside, mangiferin ferulic acid) four ethnomedicines ( G . rigescens Franch. ex Hemsl., rhodantha scabra Bunge farreri Balf. f.). The UPLC analysis was performed on Shim‐Pack XR‐ODS III (150 × 2.0...