Neurodegenerative diseases (NDDs) are mainly induced by oxidative stress which produces excessive reactive oxygen species (ROS). Quercetin (QU) is a potent antioxidant with some effects on NDDs. This study prepared and characterized novel glucose-modified QU liposome (QU–Glu–Lip), aiming not only to overcome QU’s poor water solubility bioavailability but also deliver more brain tissue enhance its neuroprotective effect. QU–Glu–Lip possessed encapsulation efficiency (EE) of 89.9%, homogenous...

"Golden-flower" Tibetan tea (GTT) is an innovative dark fermented via fungus Eurotium cristatum. To study GTT effects on alleviating the symptoms of type 1 diabetes mellitus (T1DM), GTT's extract (GTTE) was prepared. GTTE chemical compositions were analyzed HPLC, pyrolysis-gas chromatography-mass (Py-GC-MS) spectrometry analysis, and chemistry analyses. T1DM explored mice model induced by streptozotocin (STZ). composed mainly pigment theabrownin (TB) (49.18%), with high percentages...

Hulless barley contains phenolic compounds and possesses various antioxidant activities. To clarify the effects of thermal processing in vitro digestion on release hulless barley, we studied components activities after steaming, roasting processes, digestions. Both total content (TPC) flavonoid (TFC) raw (HB, 4.14 mg/g DW 1.53 DW, respectively) were higher than that steamed (SHB) roasted (RHB). In significantly released more ferulic acid from its bound form, but hydrolyzed some amount...

Macamides and Macaenes are the bioactive marker compounds in maca (Lepidium meyenii Walp., Brassicaceae) tuber. To simultaneously quantify these two types of compound, HPLC method was studied. distinguish group growing regions different samples, Hierarchical cluster analysis, a chemometric method, applied to analyze data. The calibration curves obtained using showed satisfactory linearity with determination coefficients >0.9998. precision repeatability relative standard deviation values were...

Macamides are characteristically found in maca (Lepidium meyenii Walper). Fatty acid derivatives also an important type of constituent maca, since they not only relate to the biosynthesis macamides postharvest process but possess some bioactivities. To study their comprehensive profiles tubers processed via air-drying method, ultraperformance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) analyses were performed identify macamide and fatty molecules. Their...

This study was to probe the effects of mulberry ferment on constipation (induced by diphenoxylate or loperamide) in mice. Herein, several bioactive substances and antioxidant activities were measured, their defecation, histological structure ileum intestinal microflora investigated. During fermentation, total polyphenols, flavonoids increased while a large extent. In animal experiments, caused more serious injuries than loperamide did, kept unfavorable gut microbiological environment...

Introduction Diabetic foot ulcer (DFU) stands as a severe diabetic lower extremity complication, characterized by high amputation rates, mortality, and economic burden. We propose using Mendelian randomization studies to explore shared distinct risk factors for complications. Research design methods selected uncorrelated genetic variants associated with 85 phenotypes in five categories at the genome-wide significance level instrumental variables. Genetic associations DFU, polyneuropathy...

Anthocyanidins and flavonoids are important components in plant. In present study, the anthocyanidins black hulless barley bran were identified by operating UPLC-QTOF-MS/MS. Among them, chrysoeriol-7-O-glucouronid, luteolin-7-O-glucouronid, chrysoeriol, luteolin quantified using UPLC. Additionally, total phenolic content (TPC), (TFC) anthocyanin (TAC) determined. Furthermore, antioxidant activity (via ferric reducing, DPPH ABTS method) α-glucosidase inhibition effect estimated. From results,...

Penthorum chinense Pursh (Penthoraceae) is a traditional herb used in Miao medical systems that also processed into foods (e.g., tea products) China. Different processing methods significantly affect the volatile compounds, phenolic constituents, and biological activities. This study aimed to produce P. green leaves (GTL), black (BTL), untreated (UL) investigate differences their flavor substances, functional components, antioxidant activity, alcohol dehydrogenase (ADH) acetaldehyde (ALDH)...

To study the effect of milling process on active compounds in hulless barley, β-glucan, araboxylan, free and bound forms phenolic antioxidant activities were evaluated. The results showed that total araboxylan content (9.64 g/100 g → 2.35 g) decreased significantly (P < 0.05) from outer to inner layer, while β-glucan first increased going towards layers a gradual decrease moving toward endosperm. Total phenolics flavonoids by 91% 95% with increase degree anthocyanins mostly existed layers....

The varying antioxidant potential of Citrus medica associated with different geographical regions makes the evaluation C. for natural antioxidants essential. This work aimed to compare phenolic constituents from regions. chemical compositions were characterized by ultra-high-performance liquid chromatography (UPLC) coupled mass spectrometry (MS). A total 67 compounds including 29 coumarin derivatives and 38 flavonoids tentatively identified UPLC-quadrupole time-of-flight (UPLC-Q-TOF-MS). To...

(-)-Epigallocatechin-3-gallate (EGCG) possesses potent antioxidant and neuroprotective properties. In this study, a novel glucose-modified EGCG encapsulated liposome (EGCG-Glu-Lip) was developed characterized. EGCG-Glu-Lip liposome's cytotoxicity, brain targeting ability, its antioxidative neuroprotection were examined via bEnd.3 PC12 cells testing. particle mean size 158.7 nm, with encapsulation efficiency 73.05 % under EGCG/lipid mass ratio 1:22 soybean phospholipids (SPC) to cholesterol...

Constipation, a widespread gastrointestinal disorder, often leads to the exploration of natural remedies. This study examines efficacy Golden Flower Tibetan Tea Polysaccharides (GFTTPs) in alleviating constipation mice. Chemical analyses reveal that GFTTPs possess O-H, carboxyl, carboxylic acid (-COOH), and C-O-C groups, alongside porous crystal structure with thermal stability. In animal experiments, significantly upregulated aquaporin 3 (AQP3) 8 (AQP8) expressions colon, enhancing water...

The wild plant Campanumoea lancifolia (Roxb.) Merr (also called Hong Guo ginseng, HGG), is naturally distributed in a Hmong minority area western Hunan Province, China. objective of this study was to identify, quantify, and elucidate the polyphenols anthocyanins, their antioxidant activities (via 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical 2,2ʹ-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) cation scavenging abilities) tested vitro whole fruit, fruit skin, pulp, leaves plant....

The study aims to investigate the potential action targets and molecular mechanisms of Simiao Yongan decoction (SMYAD) in treating diabetic peripheral vascular disease (DPVD) by utilizing network pharmacology analysis docking technology. components SMYAD were screened using TCMSP database, while DPVD-related genes obtained from GeneCards, OMIM, Disgenet databases. After intersecting gene sets, a Protein-Protein Interaction (PPI) was established, Gene Ontology (GO) Kyoto Encyclopedia Genes...

Resveratrol (Res) has long been discovered to have antioxidant effects prevent such as oxidation, inflammation, neurodegeneration and age-related diseases. However, its poor water solubility, low bioavailability instability become a barrier pharmaceutical application. In order improve the neuroprotective develop more potential usage of Res, three Res derivatives containing one or two glucose groups, i.e., Res-Glu1, Res-Glu2 Res-Glu3, were designed synthesized through click reaction. Res-Glu3...

Synthesis and identification of complete antigen rutin, the traditional Chinese medicine active ingredient, develop rapid detection rutin using enzyme-linked immunoassay method (ELISA). Immunogenicity was also studied.Prepare by sodium periodate solution identified UV scanning SDS-PAGE test. Male New Zealand white rabbits were immunized to obtain antiserum.The results analysis showed that coupling ratio is 13: 1. display artificial delayed compared with bovine serum protein. The titer...

Penthorum chinense Pursh is a traditional herb used in Miao medical systems that also processed into foods (e.g., tea products) China. Different processing methods significantly affect the volatile compounds, phenolic constituents, and biological activities of this herb. This study aimed to produce P. green leaves (GTL), black (BTL), untreated (UL) investigate differences their flavor substances, functional components, antioxidant activity, alcohol dehydrogenase (ADH) acetaldehyde (ALDH)...