A5085459876- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Glioma Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- Acute Kidney Injury Research
- TGF-β signaling in diseases
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Ophthalmology and Eye Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Cerebrovascular and Carotid Artery Diseases
- Cancer-related molecular mechanisms research
- Adrenal Hormones and Disorders
- COVID-19 epidemiological studies
- Sepsis Diagnosis and Treatment
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cancer, Hypoxia, and Metabolism
- Salivary Gland Tumors Diagnosis and Treatment
- Single-cell and spatial transcriptomics
- Dialysis and Renal Disease Management
- Cerebrospinal fluid and hydrocephalus
- Neuroscience of respiration and sleep
- Obstructive Sleep Apnea Research
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Peking Union Medical College Hospital
2016-2025
Sichuan University
2025
First Hospital of Jilin University
2016-2025
Jilin University
2016-2025
Jiaxing University
2025
Southeast University
2025
Peking University
2022-2024
Zhejiang University
2024
Stomatology Hospital
2024
Abstract Glioblastoma (GBM) is the most malignant and lethal intracranial tumor, with extremely limited treatment options. Immunotherapy has been widely studied in GBM, but none can significantly prolong overall survival (OS) of patients without selection. Considering that GBM cancer stem cells (CSCs) play a non-negligible role tumorigenesis chemoradiotherapy resistance, we proposed novel stemness-based classification screened out certain population more responsive to immunotherapy. The...
Glioblastoma (GBM) is the most common brain tumor with significant morbidity and mortality. Autophagy plays a vital role in GBM development progression. We aimed to establish an autophagy-related multigene expression signature for individualized prognosis prediction patients GBM. Differentially expressed genes (DE-ATGs) normal samples were screened using TCGA. Univariate multivariate Cox regression analyses performed on DE-ATGs identify optimal prognosis-related genes. Consequently, NRG1...
CD47 signaling in endothelial cells has been shown to suppress angiogenesis, but little is known about the link between and senescence. Herein, we demonstrate that thrombospondin-1 (TSP1)-CD47 pathway a major mechanism for driving cell deficiency significantly improved their angiogenic function attenuated replicative Lack of also suppresses activation cycle inhibitors upregulates expression promoters, leading increased progression. Furthermore, TSP1 accelerates senescence associated arrest...
Background: More than one-fifth of the world’s population consumes Chinese cuisines regularly, but no evidence-based healthy diets fitting food culture are available for implementation. Methods: A multicenter, patient- and outcome assessor–blind, randomized feeding trial was conducted among 265 participants with 130 to 159 mm Hg baseline systolic blood pressure (SBP) 4 major (Shangdong, Huaiyang, Cantonese, Szechuan). After a 7-day run-in period on control diet matching usual local diets,...
Bryostatins are a family of marine natural products that have garnered significant interests, as evidenced by over 40 clinical trials. However, their extremely low abundance has severely limited further research. Despite efforts, which led to the total synthesis seven bryostatin members eight independent research groups, these complex molecules present persistent challenges for stereocontrolled, large‐scale, and especially divergent synthesis. Here, we report syntheses bryostatins 1, 7, 9...
We investigated the incidence, perioperative risk factors, and outcomes of postoperative acute kidney injury (AKI) in neurosurgical critically ill patients. A prospective multicenter cohort study was conducted, enrolling adult patients who underwent procedure admitted to intensive care units (ICU). Postoperative AKI diagnosed within 7 days after surgery based on Kidney Disease Improving Global Outcomes criteria. Of 624 enrolled patients, occurred 84 associated with increased rates ICU...
Objective: To investigate the clinical and epidemiological characteristics of 135 confirmed cases COVID-19 in Tianjin. Methods: The data Tianjin were collected, analyzed with descriptive method. factors influencing severity illness analyzed. Results: Among cases, 72 males 63 females, age was (48.62±16.83) years, case fatality rate 2.22%. Local transmission caused 74.81% cases. A total 33 clusters occurred, involving 85.92% all median incubation period 6.50 days, average generation interval 5...
Although serum cystatin C (sCysC), urinary N-acetyl-β-D-glucosaminidase (uNAG), and albumin/creatinine ratio (uACR) are clinically available, their optimal combination for acute kidney injury (AKI) detection prognosis prediction remains unclear. We aimed to assess the discriminative abilities of these biomarkers possible combinations AKI intensive care unit (ICU) mortality in critically ill adults.A multicenter, prospective observational study was conducted mixed medical-surgical ICUs at...
The tumor immune microenvironment is associated with clinical outcomes and immunotherapy responsiveness.To investigate the intratumoral profile of pituitary adenomas (PAs) its relevance to explore a novel classification for predicting responsiveness.The transcriptomic data from 259 PAs 20 normal pituitaries were included analysis. ImmuCellAI algorithm was used estimate abundance 24 types tumor-infiltrating cells (TIICs) expression checkpoint molecules (ICMs).The distributions TIICs differed...
The aim of this study was to explore infectious diseases related the 2007 Huai River flood in Anhui Province, China. based on notified incidences between June 29 and July 25 from 2004 2011. Daily were compared with corresponding daily during same period other years (from 2011, except 2007) by Poisson regression analysis. Spatial autocorrelation analysis used test distribution pattern diseases. models then performed examine association incidence each disease flood, considering lag effects...
CD47 is a transmembrane protein that functions as receptor for thrombospondin-1 (TSP1) and ligand inhibitory signal-regulatory protein-α (SIRPα). Blocking the interaction between on tumor cells SIRPα macrophages has been shown to induce antitumor responses. Here we investigated role of expression in stroma tumorigenesis by comparing growth wild-type (WT) CD47-deficient mice after subcutaneous injection syngeneic prostate cancer cells. We found deficiency stromal endothelial enhances...
Objective: Facial changes are common among nearly all acromegalic patients. As they develop slowly, patients often fail to notice such before become obvious. Consequently, diagnosis and treatment delayed. So far, convenient accurate early detection of this disease is still unavailable. This study designed combine the use 3D imaging machine learning techniques in facial feature analysis identification patients, an effort ascertain how both perforomed terms applicability value disease....
Glioblastoma (GBM) is the most common and lethal primary brain tumor. In this study, we aimed to investigate differentiation states of GBM cells their clinical relevance. Integrated single-cell RNA-sequencing (scRNA-seq) data bulk RNA-seq from samples were used for analysis. Two subsets in distinct characterized, 498 cell differentiation-related genes (GDRGs) identified. GDRGs significantly correlated with immune regulation metabolic pathways. We classified patients into two groups based on...
Pediatric gliomas (PGs) are the most common brain tumors in children and leading cause of childhood cancer-related death. The understanding immune microenvironment is essential for developing effective antitumor immunotherapies. Transcriptomic data from 495 PGs were analyzed this study, with 384 as a training cohort 111 validation cohort. Macrophages infiltrates PG microenvironment, followed by T cells. classified into 3 subtypes (ISs) based on immunological profiling: "immune hot" (IS-I),...
Abstract Background Competitive endogenous RNA (ceRNA) networks have revealed a new mechanism of interaction between RNAs, and play crucial roles in multiple biological processes development neoplasms. They might serve as diagnostic prognosis markers well therapeutic targets. Methods In this work, we identified differentially expressed mRNAs (DEGs), lncRNAs (DELs) miRNAs (DEMs) sarcomas by comparing the gene expression profiles sarcoma normal muscle samples Gene Expression Omnibus (GEO)...
Studies on hyperprolactinemia and hypopituitarism in acromegaly are limited. We aimed to analyze the preoperative status, postoperative alterations, correlated factors of patients.This is a single-center cohort study with long-term follow-up. prospectively enrolled 529 patients. Hyperprolactinemia were evaluated by testing hypothalamus-pituitary-end organ (HPEO) axes hormones before after surgery.Hyperprolactinemia (39.1%) (34.8%) common acromegaly. The incidences axis-specific varied...
OBJECTIVE Treatment outcomes following initial transsphenoidal surgery (TSS) for acromegaly are erratic. Identifying outcome patterns can assist in informing patients about possible treatment and planning individualized adjuvant treatments advance. In this study, the authors aimed to investigate immediate long-term endocrine remission rates TSS acromegaly, identify clinical determinants of outcomes, explore during a follow-up pattern-specific patient features. METHODS This prospective,...
Cystatin C (Cys C) used clinically for detecting early acute kidney injury (AKI) was reported to be associated with thyroid function. Therefore, whether the performance of Cys is affected by hormones has raised concern in critically ill patients. This study aimed investigate impact on diagnostic and predictive accuracy AKI, hence optimize clinical application C. A prospective observational conducted general intensive care units (ICUs). Serum creatinine (SCr), C, function were documented all...
Introduction: The body of glioma-related literature has grown significantly over the past 25 years. Despite this growth in amount published research, gliomas remain one most intransigent cancers. purpose study was to analyze landscape research years using machine learning and text analysis. Methods: In April 2019, we downloaded publications indexed PubMed between 1994 2018. We used Python extract title, publication date, MeSH terms, abstract from metadata each for bibliometric assessment....
Abstract Background Without sufficient evidence in postoperative acute kidney injury (AKI) critically ill patients undergoing emergency surgery, it is meaningful to explore the incidence, risk factors, and prognosis of AKI. Methods A prospective observational study was conducted general intensive care units (ICUs) from January 2014 March 2018. Variables about preoperation, intraoperation postoperation were collected. AKI diagnosed using Kidney Disease: Improving Global Outcomes criteria....