A5101135408- Reproductive Biology and Fertility
- Assisted Reproductive Technology and Twin Pregnancy
- Ovarian function and disorders
- Prenatal Screening and Diagnostics
- Reproductive Health and Technologies
- Reproductive System and Pregnancy
- Renal and related cancers
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Pregnancy and Medication Impact
- RNA modifications and cancer
- Endometriosis Research and Treatment
- Cancer-related molecular mechanisms research
- Sperm and Testicular Function
- RNA Research and Splicing
- Microtubule and mitosis dynamics
- Ectopic Pregnancy Diagnosis and Management
- Chromosomal and Genetic Variations
- Pluripotent Stem Cells Research
- Epigenetics and DNA Methylation
- Electrolyte and hormonal disorders
- Gynecological conditions and treatments
- Genomic variations and chromosomal abnormalities
- Genetic Syndromes and Imprinting
Suzhou Municipal Hospital
2016-2025
Nanjing Medical University
2016-2025
Yuhuangding Hospital
2022
Shandong University
2022
Jinan University
2022
Creative Commons
2018
Zhengzhou People's Hospital
2013
Women's Hospital, School of Medicine, Zhejiang University
2006-2008
Xinjiang Institute of Ecology and Geography
2005
Embryo selection with preimplantation genetic testing for aneuploidy (PGT-A) may improve pregnancy outcomes after initial embryo transfer. However, it remains uncertain whether PGT-A improves the cumulative live-birth rate as compared conventional in vitro fertilization (IVF).
Abstract Background With the development of regenerative medicine and tissue engineering technology, almost all stem cell therapy is efficacious for treatment premature ovarian failure (POF) or insufficiency (POI) animal models, whereas little has been practiced in clinical settings. The underlying molecular mechanism safety POI are not fully understood. In this study, we explored whether fetal mesenchymal cells (fMSCs) from liver restore function melatonin membrane receptor 1 (MT1) acts as...
It has been consistently shown in several meta-analyses that infants born after ART have an excess of birth defects compared with those spontaneous conception, however, the prevalence among offspring China is incompletely studied. Moreover, it unclear to what extent risk associated parental infertility characteristics, specific procedures and twinning.In prospective cohort study, we included women who participated cohort, had pregnancies at least 20 gestational weeks between August 2016 May...
Abstract Background Oocyte maturation arrest and early embryonic are important reproductive phenotypes resulting in female infertility cause the recurrent failure of assisted technology (ART). However, genetic etiologies these infertility-related poorly understood. Previous studies have mainly focused on inherited mutations based large pedigrees or consanguineous patients. role de novo (DNMs) remains to be elucidated. Results To decipher DNMs ART with oocyte embryo defects, we explore...
Abstract Background Before starting gonadotoxic therapies, cryopreservation of mature sperm has been proposed worldwide as a method for male fertility preservation and enabling the conception healthy baby with assisted reproductive technology (ART); however, these technologies are not feasible prepubertal boys men spermatogenic failure. Transplantation mesenchymal stem cells exhibited successful therapeutic benefits in restoring spermatogenesis via gonadal graft angiogenesis, transplanted...
Oocyte maturation and fertilization are fundamental processes for successful human reproduction, abnormalities in these will cause infertility. Recently, we identified biallelic mutations CDC20 that responsible oocyte arrest, failure, early embryonic development arrest. In this study, screened further a new cohort of patients with maturation, fertilization, development. Through whole-exome sequencing, the four novel c.887G > A (p. Arg296Gln), c.964C T (p.Arg322 ∗ ), c.1155G C...
Introduction Asthenozoospermia (AZS) is a leading cause of male infertility, affecting an estimated 18% infertile patients. Kinesin proteins function as molecular motors capable moving along microtubules. The highly conserved kinesin family member 9 ( KIF9 ) localizes to the central microtubule pair in flagella Chlamydomonas cells. loss expression mice has been linked AZS phenotypes. Methods Variant screening was performed by whole exome sequencing from 92 Chinese patients with AZS. Western...
Journal Article Cohort Profile: The Jiangsu Birth Get access Jiangbo Du, Du State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, ChinaDepartment Epidemiology Biostatistics, School Public China Search for other works by this author on: Oxford Academic PubMed Google Scholar Yuan Lin, Lin Maternal, Child Adolescent Center Global Yankai Xia, Xia ChinaKey Modern Toxicology Ministry Education, https://orcid.org/0000-0003-0484-4035 Hongxia Ma, Ma...
Endometriosis is a prevalent gynecological disorder, yet data on the role of trace metal elements in its risk remain limited. We aimed to investigate relationship between serum copper (Cu), zinc (Zn), iron (Fe), magnesium (Mg) levels, and Cu/Zn ratio with endometriosis. This study involved 568 infertile patients diagnosed endometriosis, compared 819 without endometriosis (Control group). Basic characteristics, hormonal parameters, essential were measured analyzed. The findings indicated...
To develop a novel preimplantation genetic screening (PGS) test using next generation sequencing(NGS) as alternative to current array comparative genomic hybridization (array CGH) method for detection of small segmental translocations in two patients with repeated implantation failure (RIF) and recurrent miscarriage (RM). Inconsistent results were resolved by validation fluorescence situ (FISH).One couple normal cytogenetic CGH result suffered from failure. Later NGS analysis showed...
Psychological distress may exert a negative influence on reproductive function of couples at age. Couples seeking assisted technology (ART) treatment have higher prevalence psychological than fertile couples. However, whether is associated with the outcome ART remains unknown. We aimed to investigate association pre-treatment and clinical pregnancy rate among infertility undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment.This nested case-control...
Introduction Abnormal placental development can lead to adverse outcomes for both mother and fetus. The effect of different types endometrium preparation regimens frozen-thawed cycles on the features associated with perinatal remains unclear. Hence, we conducted a retrospective cohort study assess impact specific endometrial placenta-mediated pregnancy complications in singleton live births. Methods A was evaluating data all births conceived naturally or by vitro fertilization (IVF) therapy...
Abstract The association between serum copper and polycystic ovary syndrome (PCOS) lacks definitive conclusions, the intricate interactions with in vitro fertilization (IVF) cycle characteristics infertility remain insufficiently explored. This retrospective study included 560 patients tubal (no‐PCOS) 266 PCOS undergoing IVF at Affiliated Suzhou Hospital of Nanjing Medical University from January 2018 to December 2022. Patients' basic characteristics, hormonal metabolic parameters, essential...