A5100431461- Cyclopropane Reaction Mechanisms
- Catalytic C–H Functionalization Methods
- Catalytic Cross-Coupling Reactions
- Catalytic Alkyne Reactions
- Synthetic Organic Chemistry Methods
- Organoboron and organosilicon chemistry
- Chemical Synthesis and Analysis
- Asymmetric Hydrogenation and Catalysis
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Sulfur-Based Synthesis Techniques
- Reproductive Biology and Fertility
- Autophagy in Disease and Therapy
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Radical Photochemical Reactions
- Monoclonal and Polyclonal Antibodies Research
- Synthesis and Catalytic Reactions
- Fluorine in Organic Chemistry
- Ocular Surface and Contact Lens
- Boron Compounds in Chemistry
- Parathyroid Disorders and Treatments
- Cardiovascular Health and Disease Prevention
- Glycosylation and Glycoproteins Research
- Chemical Synthesis and Reactions
Liaocheng People's Hospital
2022-2025
Zhengzhou University
2021-2025
Second Hospital of Yichang
2023-2025
Tianjin Agricultural University
2025
Suzhou Municipal Hospital
2016-2024
Nanjing Medical University
2016-2024
Zunyi Medical University
2023-2024
Tianjin University of Science and Technology
2016-2024
Guangdong Academy of Agricultural Sciences
2016-2024
First Affiliated Hospital of Gannan Medical University
2022-2023
A coupling reaction of N-phenoxyacetamides with N-tosylhydrazones or diazoesters through Rh(III) -catalyzed CH activation is reported. In this reaction, ortho-alkenyl phenols were obtained in good yields and excellent regio- stereoselectivity. Rh-carbene migratory insertion proposed as the key step mechanism.
Cross-coupling reactions involving metal-carbene are emerging as a new type of carbon-carbon bond-forming reaction. The aim this JOCSynopsis is to provide an overview the most recent development these reactions, focusing on use diazo compounds (or in situ formed from N-tosylhydrazones) carbene precursors. In addition, integration reaction with C-H bond functionalization also surveyed.
A Rh(I)-catalyzed formal carbene insertion into C–C bond of benzocyclobutenols has been realized by employing diazoesters as precursors. The product indanol derivatives were obtained in good yields and diastereoselective manner under mild reaction conditions. All-carbon quaternary center is constructed at the carbenic carbon. This catalytic involves selective cleavage bond, Rh(I) insertion, intramolecular aldol reaction.
Premature ovarian failure (POF) is one of the most common causes infertility in women. In our present study, we established cyclophosphamide- (CTX-) induced POF rat model and elucidated its effect on function. We detected serum estrogen, follicle stimulating hormone, anti-Müllerian hormone mice models by ELISA evaluated their folliculogenesis histopathology examination. Our study revealed that CTX administration could severely disturb secretion influence rat. This also cells apoptosis...
Ahead of the PAC: Polycyclic aromatic compounds (PACs) can be easily accessed by combination Suzuki–Miyaura cross-coupling and a [Rh2(OAc)4]-catalyzed carbene reaction using available bis(N-tosylhydrazone)s as intermediates (see scheme; Ts=4-toluenesulfonyl). Detailed facts importance to specialist readers are published "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made submitted authors. Please note: The publisher is responsible for content...
The first Pd(0)-catalyzed carbene insertion into Si-Si and Sn-Sn bonds has been realized by using N-tosylhydrazones as the precursors. Geminal bis(silane) geminal bis(stannane) derivatives were obtained in good to excellent yields under mild conditions. Migratory of Pd is supposed be key step for reaction.
We report herein a highly efficient palladium-catalyzed carbene insertion into strained Si–C bonds with excellent enantioselectivity, which provides rapid and distinct method to access silacyclopentanes three- or four-substituted stereocenter asymmetrically. Mechanistic studies using hybrid density functional theory suggest catalytic cycle involving oxidative addition, migratory insertion, reductive elimination. In roles of the chiral ligands in controlling reaction enantioselectivity are...
Abstract Intramolecular aromatic substitution and Büchner reaction have been established as powerful methods for the construction of polycyclic compounds. These reactions are traditionally catalyzed by Rh II catalysts with α‐diazocarbonyl compounds substrates. Herein a transition‐metal‐free intramolecular substitution/Büchner is presented. use readily available N ‐tosylhydrazones diazo compound precursors show wide substrate scope.
Abstract A coupling reaction of N ‐phenoxyacetamides with ‐tosylhydrazones or diazoesters through Rh III ‐catalyzed CH activation is reported. In this reaction, ortho ‐alkenyl phenols were obtained in good yields and excellent regio‐ stereoselectivity. Rh–carbene migratory insertion proposed as the key step mechanism.
Mild conditions, no photocatalyst, broad substrate scope.
The different reactivity of two kinds carbonyl groups in keto aldehyde substrates has been exploited for the synthesis phenanthrols, naphthols, and their heteroatom-containing analogues. Key to this highly efficient robust methodology is catalyst-free intramolecular formal diazo carbon insertion N-tosylhydrazones into C-C bonds.
A novel protocol for the synthesis of phenanthrenes through copper-catalyzed reaction aromatic tosylhydrazones with terminal alkynes is explored. The proceeds via formation an allene intermediate and subsequent six-π-electron cyclization–isomerization, affording phenanthrene derivatives in good yields. transformation can be performed two ways: (1) N-tosylhydrazones derived from [1,1′-biphenyl]-2-carbaldehydes as starting materials (2) aldehydes 2-alkynyl biphenyls materials. This new uses...
A Pd-catalyzed stereoselective synthesis of 3-vinylindoles and 3-vinylbenzofurans has been developed. The reaction merges the alkyne-based cyclization Pd carbene migratory insertion in a single catalytic cycle, generating C–C bond C═C double one operation.
Despite notable progress, olefin metathesis methods for preparation of (Z)-α,β-unsaturated carbonyl compounds, applicable to the synthesis a large variety bioactive molecules, remain scarce. Especially desirable are transformations that can be promoted by ruthenium-based catalysts, as such entities would allow direct access carboxylic esters and amides, or acids (in contrast molybdenum- tungsten-based alkylidenes). Here, we detail how, based on mechanistic insight obtained through...
Targeting the PD‐1/PD‐L1 immune checkpoints has achieved significant positive results in treatment of multiple cancers. Quercetin is one most abundant dietary flavonoids found various vegetables and fruits, a wide range biological activities including immunomodulation. Here we report that quercetin dihydrate was screened shown to inhibit interaction. Treatment with promoted killing activity T cells on MDA‐MB‐231 NCI‐H460 cancer cells. Experiments using xenograft mouse model showed growth...
A general photo-induced regioselective hydroboration of alkenes without photocatalyst or an external initiator has been developed through in situ formed boryl radicals. Thiol plays the dual role as a proton donor and hydrogen atom transfer catalyst.
The side effects of busulfan on male reproduction are serious, so fertility preservation in children undergoing treatment is a major worldwide concern. Human placental mesenchymal stem cells (hPMSCs) have advantages such as stable proliferation and lower immunogenicity that make them an ideal material for stimulating tissue repair, especially restoring spermatogenesis. protective hPMSCs busulfan-induced Sertoli busulfan-treated mouse testes not been determined. Our study aimed to elaborate...
Caffeine promotes expression of <italic>TERT</italic>, consequently increases telomere length, prevents cellular senescence and delays aging phenotypes in mice.
We report herein a highly efficient palladium-catalyzed carbene insertion into strained Si-C bonds of benzosilacyclobutanes, which provides an method to access α-chiral silanes. With sterically hindered ligand, the C(sp3 )-Si bond benzosilacyclobutanes occurred in excellent site- and enantioselectivity, while C(sp2 selectively with less ligands. Reaction mechanism, particular roles chiral ligands controlling site-selectivity reactions, are elucidated by using hybrid density functional theory.
The last two years have witnessed unprecedentedly wide applications of acylsilanes in many fields well beyond pure organic synthesis. This highlight covers selected representative examples and focuses on their possible the future.
Abstract Objective The association of the triglyceride-glucose (TyG) index with intracranial atherosclerotic stenosis (ICAS) and extracranial (ECAS) is unclear. This study aimed to investigate relationship TyG distribution severity ICAS ECAS. Method Patients who underwent digital subtraction angiography (DSA) for evaluating ICAS/ECAS in Zhongnan Hospital Wuhan University from January 2017 October 2021 were retrospectively enrolled our study. Clinical characteristics, DSA data, blood routine,...
1<italic>H</italic>-Indazoles have been synthesized from readily available <italic>N</italic>-tosylhydrazones and nitroaromatic compounds under mild reaction conditions.
Pd(0)-Catalyzed formal carbene insertion into Si-H bonds has been achieved as an efficient method for C(sp3)-Si bond formation. The reaction, which uses readily available N-tosylhydrazones the diazo precursors, is highly and shows a wide substrate scope. Rh(ii) Cu(i) salts, are widely used catalysts reactions, have proved to be ineffective current reaction. A Pd(ii) migratory insertion/reductive elimination mechanism proposed.