A5073200500- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Cancer Cells and Metastasis
- Angiogenesis and VEGF in Cancer
- Pluripotent Stem Cells Research
- Hematopoietic Stem Cell Transplantation
- Renal Transplantation Outcomes and Treatments
- Pancreatic function and diabetes
- MicroRNA in disease regulation
- Pharmacological Effects of Natural Compounds
- Advanced Radiotherapy Techniques
- Reproductive System and Pregnancy
- Organ Transplantation Techniques and Outcomes
- Cancer-related Molecular Pathways
- Electrospun Nanofibers in Biomedical Applications
- Radiation Therapy and Dosimetry
- Cancer, Hypoxia, and Metabolism
- Cancer Mechanisms and Therapy
- Neonatal Respiratory Health Research
- Biomedical Ethics and Regulation
- Cardiac Ischemia and Reperfusion
- Circular RNAs in diseases
- Natural product bioactivities and synthesis
Fujian Medical University
2016-2025
Union Hospital
2016-2025
Fujian University of Traditional Chinese Medicine
2011-2023
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2017
Wenzhou Medical University
2017
Xiamen University
2010-2015
University of Houston
2014-2015
The University of Texas MD Anderson Cancer Center
2013-2015
Tianjin First Center Hospital
2015
Huazhong University of Science and Technology
2015
<h3>Context</h3>Antibody-based induction therapy plus calcineurin inhibitors (CNIs) reduce acute rejection rates in kidney recipients; however, opportunistic infections and toxic CNI effects remain challenging. Reportedly, mesenchymal stem cells (MSCs) have successfully treated graft-vs-host disease.<h3>Objective</h3>To assess autologous MSCs as replacement of antibody for patients with end-stage renal disease who undergo ABO-compatible, cross-match–negative transplants from a living-related...
Mesenchymal stem cells (MSCs) reportedly inhibit the mixed lymphocyte reaction. Whether this effect is mediated by dendritic (DCs) still unknown. In study, we used an in vitro model to observe effects of MSCs and their supernatants on development monocyte-derived DCs. Phenotypes endocytosic ability harvested DCs were determined flow cytometry; interleukin 12 (IL-12) secreted was evaluated enzyme-linked immunosorbent assay (ELISA); antigen-presenting function MLR. Our results show that...
Background and Objectives The use of mesenchymal stem cells (MSC) for cell therapy relies on the capacity these to home engraft long-term into appropriate target tissue(s). Homing MSC bone marrow (BM) post-transplantation can occur, but does so with only poor efficiency. This study was designed evaluate role SDF-1/CXCR4 axis in homing Flk1+ derived from human fetal BM.Design Methods We investigated expression CXCR4 stimulated a cytokine cocktail explored their ability 24 hours after...
Fibrosis is the common end stage of most liver diseases, for which, unfortunately, there no effective treatment available currently. It has been shown that mesenchymal stem cells (MSCs) from bone marrow (BM) could engraft in lung after bleomycin exposure and ameliorate its fibrotic effects. This study was designed to evaluate effect Flk1 MSCs murine BM (termed here mMSCs) on fibrosis formation induced by carbon tetrachloride (CCl4).A CCl(4)-induced hepatic model used. mMSCs were systemically...
A better understanding of the molecular mechanisms underlying differentiation human adipose tissue-derived mesenchymal stem cells (hAD-MSCs) could provide new insights into pathogenesis a number diseases, such as obesity and diabetes, broaden spectrum potential hAD-MSCs-based cell therapy. In this study, we reported that microRNA, hsa-miR-138, inhibit adipogenic hAD-MSCs. Our results showed miR-138 was significantly down-regulated during differentiation. Overexpression in hAD-MSCs...
OBJECTIVE To determine the safety and effects on insulin secretion of umbilical cord (UC) mesenchymal stromal cells (MSCs) plus autologous bone marrow mononuclear cell (aBM-MNC) stem transplantation (SCT) without immunotherapy in established type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS Between January 2009 December 2010, 42 patients with T1D were randomized (n = 21/group) to either SCT (1.1 × 106/kg UC-MSC, 106.8 aBM-MNC through supraselective pancreatic artery cannulation) or standard...
Objective: This study was aimed to examine the psychological impact of COVID-2019 outbreak on medical staff in China.Methods: In February 2020, an online survey carried out by using a WeChat tool evaluate effects mental health around China.Results: A total 11118 responded survey. About 4·98% respondents reported middle and high levels anxiety while 13·47% depression since COVID-19 outbreak. Nurses, frontline younger were more likely have than physicians, non- older respectively.Conclusions:...
Bone marrow-derived mesenchymal stem cells (bMSCs) can differentiate into a number of different cell/tissue types, and also possess immunoregulatory functions. The present study was undertaken to elucidate the exact effects allogeneic bMSCs on T- B-lymphocyte proliferation, activation, function maturation BXSB mice, which has been considered as experimental model for human systemic lupus erythematosus (SLE). We determined that from BALB/c mice had inhibitory T-lymphocyte but no effect their...
Stem cell plasticity has created great interest because of its potential therapeutic application in degenerative or inherited diseases. Transplantation bone marrow-derived stem cells was shown to give rise muscle, liver, nerve, endothelium, epithelium, and so on. But there are still disputes about plasticity, especially concerning the contribution skin cells. In this study, CM-DiI fluorescence-labeled Flk-1+ marrow mesenchymal (bMSCs) BALB/c mice (H-2Kd, white) were transplanted into...