A5101593088- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Alzheimer's disease research and treatments
- Pain Mechanisms and Treatments
- Regulation of Appetite and Obesity
- Pancreatic function and diabetes
- Neurological Disease Mechanisms and Treatments
- Biochemical Analysis and Sensing Techniques
- Testicular diseases and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Hearing, Cochlea, Tinnitus, Genetics
- Stress Responses and Cortisol
- Mitochondrial Function and Pathology
- TGF-β signaling in diseases
- Vitamin D Research Studies
- Nerve injury and regeneration
- Diabetes and associated disorders
- Neuroscience of respiration and sleep
- Helicobacter pylori-related gastroenterology studies
- Traditional Chinese Medicine Studies
- Glaucoma and retinal disorders
- Acute Ischemic Stroke Management
Anhui Academy of Agricultural Sciences
2025
Changchun University of Chinese Medicine
2025
China Medical University
2024
Nanjing Medical University
2017-2023
Shanghai Sixth People's Hospital
2019-2023
Shanghai Jiao Tong University
2019-2023
Shanghai Ninth People's Hospital
2023
Huaian First People’s Hospital
2017-2023
Children's Hospital of Chongqing Medical University
2022
Chongqing Medical University
2022
Leptin, an adipocyte-secreted hormone, is one of the central regulators body weight homeostasis. In humans and rodents, two major forms leptin receptors (OB-R) are expressed. The short form (OB-R<sub>S</sub>), considered to lack signaling capability, detected in many organs. contrast, OB-R long (OB-R<sub>L</sub>) predominates hypothalamus, but also present at low levels peripheral tissues. Transient transfection experiments have demonstrated that OB-R<sub>L</sub> transduces intracellular...
Leptin (OB), an adipocyte-secreted circulating hormone, and its receptor (OB-R) are key components of endocrine loop that regulates mammalian body weight. In this report we have analyzed signal transduction activities OB-R containing the fatty mutation [OB-R( fa )], a single amino acid substitution at position 269 (Gln → Pro) in extracellular domain results obese phenotype rat. We find mutant exhibits both ligand-independent transcriptional activation via interleukin 6 hematopoietin response...
The development of experimental autoimmune encephalomyelitis (EAE), a model multiple sclerosis, has been studied in mice that were (i) vitamin D-deficient, (ii) minus the D receptor, (iii) 25-hydroxylase, and (iv) 25-hydroxyvitamin D-1α-hydroxylase. EAE was markedly suppressed lacking receptor partially D-insufficient mice. However, absence either two key hydroxylases (i.e., 25-hydroxylase 1α-hydroxylase) neither inhibits nor enhances EAE. These results indicate are required for also suggest...
BACKGROUND:We desired to observe the changes of transforming growth factor-β1/drosophila mothers against decapentaplegic protein (TGF-β1/Smad3) signaling pathway in hippocampus region cerebral ischemic stroke rats so that effects this on nerve cells can be investigated. MATERIAL AND METHODS:The models were built by middle artery occlusion (MCAO) vivo and oxygen-glucose deprivation (OGD) vitro. TGF-β1 inhibitors injected into rat while TGF-β1, siRNA, Smad3, Smad3 siRNA transfected cells....
Few studies have focused on the association between lifestyle and subclinical hypothyroidism (SCH). The purpose of this study was to investigate thyroid function in SCH.This a part community-based cross-sectional study, Epidemiological Survey Thyroid Diseases Fujian Province, China. A total 159 participants with SCH (81 males 78 females) euthyroid (87 72 without any missing data were included analysis. General information including sleep, exercise, diet smoking habits collected by...
The present study was designed to investigate the effect of vitrification on mitochondrial distribution, membrane potential (Deltapsi) and microtubule distribution in mouse 2-PN embryos, as well document relationship between developmental ability those embryos. Mitochondrial examined by fluorescence microscopy technology. Results indicated that: (1) rate ring formation around pronuclei vitrified embryos significantly lower than fresh ones (67.3 +/- 3.0% vs. 84.9 3.1%) (P < 0.05). (2)...
Sigmoidovaginal fistula (SVF) is an extremely distressing and complex condition that significantly impacts a patient’s quality of life. The successful management SVF relies on accurately identifying the fistula’s location tract. However, preoperative localization can be challenging in certain cases. In this report, we describe rare complication patient with stage IVA cervical cancer who developed after concurrent chemoradiotherapy. Conventional diagnostic methods, including electron...
Peppers are widely cultivated around the world, yet they suffer from infections caused by Phytophthora capsici fungi throughout year, which severely impacts their yield. The β-1,3-glucanase gene has been shown in previous studies to significantly enhance plants’ ability cope with both biotic and abiotic stresses, including fungal infections. However, its function peppers not reported. In this study, 80 CaBG genes were initially identified, before being filtered down 54 CaBGs peppers,...
Chronic constriction injury (CCI) of the sciatic nerve may induce dorsal root ganglion (DRG) neuronal hyperexcitability and behaviorally expressed hyperalgesia. CCI is a model neuropathic pain. To investigate association between expression protease activated receptor 2 (PAR2), TMEM16A pain, PAR2 proteins in DRG neurons rats following was investigated. Following creation model, thermal withdrawal latency (TWL) examined by hot plate test. An immunofluorescence assay western blot were performed...
Isolated human immunoglobulin G (IgG) CH2 domains are promising scaffolds for novel candidate therapeutics. Unlike other IgG domains, is not involved in strong interchain interactions, and isolated relatively stable. However, single prone to aggregation. In native Fc molecules, the N-terminal residues of from two heavy chains interact with each form hinge regions. By contrast, highly disordered CH2. We have hypothesized that removal may only increase its stability but also aggregation...
To investigate the therapeutic effects and acting mechanism of a combination Chinese herb active components, i.e., baicalin, jasminoidin cholic acid (CBJC) on Alzheimer's disease (AD).Male rats were intracerebroventricularly injected with ibotenic (IBO), CBJC was orally administered. Therapeutic effect evaluated Morris water maze test, FDG-PET examination, histological studied DNA microarrays western blotting.CBJC treatment significantly attenuated IBO-induced abnormalities in cognition,...
Calcium dobesilate (Cad), a protective agent, protects against microvascular damage, and diseases such as diabetic retinopathy nephropathy. However, these vascular effects have not been demonstrated in chronic kidney disease (CKD). In this study, we aimed to determine the ability of Cad protect renal interstitial fibrosis induced by unilateral ureteral obstruction (UUO) identify underlying therapeutic mechanisms during hypoxia/serum deprivation (H/SD) human umbilical vein endothelial cells...
Abstract Objective Betaine–homocysteine methyltransferase (Bhmt) belongs to the family of methyltransferases and is involved in one‐carbon metabolic cycle, which associated with risk diabetes adiposity. This study aimed explore whether Bhmt participated development obesity or its diabetes, as well mechanism involved. Methods The expression levels were examined stromal vascular fraction cells mature adipocytes nonobesity. Knockdown overexpression C3H10T1/2 used investigate Bhmt's function...
Summary Aims To compare the once‐daily rivastigmine patch 9.5 mg/24 h (10 cm 2 ) versus twice‐daily capsule (12 mg/day) in Chinese patients with probable Alzheimer's disease ( AD (mini‐mental state examination [ MMSE ] scores of 10–20). Methods The primary objective was to demonstrate noninferiority Disease Assessment Scale‐Cognitive subscale ADAS ‐Cog) change from baseline 24 week. Secondary endpoints included cognition ), overall clinical response (Alzheimer's Cooperative Study‐Clinical...
Abstract BACKGROUND: Cryptorchidism is one of the most common congenital anomalies and associated with increased risk for infertility testicular cancer later in life. Findings from animal models small clinical studies suggest that posterior HOX genes (paralogs 9–13) could be potential candidate cryptorchidism are functionally redundant within paralogous groups. METHODS : The coding regions exon‐intron boundaries 16 were sequenced analyzed group 1 (44 nonsyndromic cases 46 healthy controls)....
Primary Objective: We aim to study the effects of chronic aminoguanidine (AG) administration on learning and memory impairment after TBI explore potential mechanism involved in this process.Research Design: Male C57BL/6J mice were divided into 6 groups: Control, + Veh, TBI+ AG (50, 100, 200 400 mg/kg, i.p.).Methods Procedures: Then, we measured cyclicadenosine 3ʹ, 5ʹ-monophosphate (cAMP) content, phosphorylated form cAMP-response element binding protein (p-CREB) level, iNOS, brain-derived...