A5103090528- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Lipid metabolism and biosynthesis
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Organ Donation and Transplantation
- Obstructive Sleep Apnea Research
- Signaling Pathways in Disease
- RNA modifications and cancer
- Pancreatic function and diabetes
- Cancer-related gene regulation
- Cardiac electrophysiology and arrhythmias
- Tryptophan and brain disorders
- Biochemical Acid Research Studies
- Inflammasome and immune disorders
- Bone Metabolism and Diseases
- Polyomavirus and related diseases
- Histone Deacetylase Inhibitors Research
- Renal Diseases and Glomerulopathies
- Lipid metabolism and disorders
- Acute Kidney Injury Research
Shanghai Jiao Tong University
2009-2025
Shanghai Sixth People's Hospital
2023-2025
Shanghai Ninth People's Hospital
2018-2024
Weihai Chest Hospital
2023
Ruijin Hospital
2005
Pyruvate and branched-chain amino acid (BCAA) metabolism are pivotal pathways in tumor progression, yet the intricate interplay between them its implications for progression remain elusive. Our research reveals that dihydrolipoamide S-acetyltransferase (DLAT), a pyruvate enzyme, promotes leucine accumulation sustains mammalian target of rapamycin (mTOR) complex activation hepatocellular carcinoma (HCC). Mechanistically, DLAT directly acetylates K109 residue AU RNA-binding...
The role of RNA methylation on the sixth N atom adenylate (m6A) in acute kidney injury (AKI) is unknown. FTO (fat mass and obesity-associated protein) reverses m6A modification cisplatin-induced AKI. Here, we aimed to determine FTO's We induced AKI c57BL/6 mice by intraperitoneal cisplatin injection treated animal with vehicle or an inhibitor meclofenamic acid (MA) for 3 days. Moreover, as vitro model, human proximal tubular cells (HK2 cells) were cisplatin. found that treatment reduces...
To investigate the expression of long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in renal ischemia-reperfusion injury and explore its role acute kidney injury.18 mice were randomly divided into a sham operation group (Sham) an (IR) which animals sacrificed at 6 h or 12 after surgery. The kidneys harvested to measure MALAT1 mRNA. HK2 cells treated with cobalt chloride (CoCl2) mimic hypoxia transfected siRNA knockdown before CoCl2 treatment. After that, was...
Obstructive sleep apnea syndrome (OSAS), characterized by chronic intermittent hypoxia (CIH), is an independent risk factor for aggravating non-alcoholic steatohepatitis (NASH). The prevailing mouse model employed in CIH research inadequate the comprehensive exploration of impact on NASH development due to reduced food intake observed CIH-exposed mice, which deviates from human responses. To address this issue, a pair-feeding investigation with and normoxia-exposed mice conducted. It...
Nonalcoholic fatty liver disease (NAFLD) is considered a risk factor for cardiovascular and cerebrovascular owing to its close association with coagulant disturbances. However, the precise biological functions mechanisms that connect coagulation factors NAFLD pathology remain inadequately understood. Herein, unbiased bioinformatics analyses followed by functional testing, we demonstrate hepatic expression of VII (FVII) decreases in patients mice NAFLD/nonalcoholic steatohepatitis (NASH). By...
Summary As a novel immunosuppressant, FTY720 (2-amino-2-(2-[4-octylphenyl] ethyl)-1, 3-propanediol hydrochloride) has been used to prevent the allograft rejection in organ transplantation. can prolong markedly survival of by inducing apoptosis reactive lymphocytes and redirecting homing lymphocytes. However, as archetype new class immune modulators, potential effect on response needs be elucidated further. In this study, was added into mixed lymphocyte reaction (MLR) consisting murine...
Abstract Objective Betaine–homocysteine methyltransferase (Bhmt) belongs to the family of methyltransferases and is involved in one‐carbon metabolic cycle, which associated with risk diabetes adiposity. This study aimed explore whether Bhmt participated development obesity or its diabetes, as well mechanism involved. Methods The expression levels were examined stromal vascular fraction cells mature adipocytes nonobesity. Knockdown overexpression C3H10T1/2 used investigate Bhmt's function...
Introduction: Acute kidney injury (AKI) is a common clinical syndrome associated with high morbidity and mortality. Inhibition of the methyltransferase Enhancer Zeste Homolog 2 (EZH2) by its inhibitor 3-DZNeP (3-Deazaneplanocin A) exerts renal benefits in acute ischemia-reperfusion (IRI). However, underlying mechanisms not completely known. This study aimed to elucidate pathological mechanism EZH2 IRI combination multi-omics analysis expression profiling public cohort. Methods: In this...
Abstract Diverse extraintestinal diseases are characterized by localized inflammatory responses and tissue damage, accompanied with intestinal inflammation injury. Here, a dual‐functionality dual‐location intervention strategy is reported, which the use of hyaluronic acid‐nanocoated Clostridium butyricum to generate an anti‐inflammatory tissue‐repair effect in impaired gut organs. Nanocoated bacteria attenuate mucosal recover barrier integrity leveraging immunosuppressive nature acid...
Acute kidney injury (AKI) is a clinical syndrome characterized by significant morbidity and high death rate. Interleukin (IL)-27 newly described member of the IL-6/IL-12 heterodimeric cytokine family displays anti-inflammatory antiapoptotic properties.To determine effect mechanism IL-27 in AKI.We used mouse model renal ischemia/reperfusion (I/R) to investigate whether has therapeutic potential for treatment AKI. For administration group, protein was injected 1 h before ischemia. Human...
The in vivo immunoregulatory effect of anergic cells induced by blocking the costimulatory pathway was investigated this study. Anergic were generated vitro mixed culture murine splenic from BALB/c and C3H/HeJ under blockade anti-CD154 anti-CD80 monoclonal antibodies, activity observed. 3.0 Gy gamma-irradiated mice received cardic allografts C3H/HeJ, intravenously injected immediately after transplantation. Recipient with also rapamycin therapy (1 mg/kg/day) for 14 days. On day 7...
<p dir="ltr">NAFLD is considered as a risk factor for cardiovascular and cerebrovascular disease owing to its close association with coagulant disturbances. However, the precise biological functions mechanisms that connect coagulation factors NAFLD pathology remain inadequately understood.<b><i> </i></b>Herein, unbiased bioinformatic analyses followed by functional test, we demonstrate hepatic expression of FVII decreases in patients mice NAFLD/NASH. By...
<p dir="ltr">NAFLD is considered as a risk factor for cardiovascular and cerebrovascular disease owing to its close association with coagulant disturbances. However, the precise biological functions mechanisms that connect coagulation factors NAFLD pathology remain inadequately understood.<b><i> </i></b>Herein, unbiased bioinformatic analyses followed by functional test, we demonstrate hepatic expression of FVII decreases in patients mice NAFLD/NASH. By...