A5001270372- Hernia repair and management
- Intestinal and Peritoneal Adhesions
- Cerebrovascular and Carotid Artery Diseases
- Evaluation and Optimization Models
- Minimally Invasive Surgical Techniques
- Appendicitis Diagnosis and Management
- Vascular anomalies and interventions
- Cytokine Signaling Pathways and Interactions
- Urologic and reproductive health conditions
- Extracellular vesicles in disease
- High-Temperature Coating Behaviors
- FOXO transcription factor regulation
- Colorectal Cancer Surgical Treatments
- Ideological and Political Education
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Immune cells in cancer
- Pelvic and Acetabular Injuries
- Cytomegalovirus and herpesvirus research
- Online and Blended Learning
- Testicular diseases and treatments
- Social Capital and Networks
- Colorectal and Anal Carcinomas
- Caveolin-1 and cellular processes
- Education and Learning Interventions
Xinxiang Medical University
2025
Shanghai First People's Hospital
2011-2024
Shanghai Jiao Tong University
2013-2024
Lishui Central Hospital
2024
Affiliated Hospital of Nantong University
2020-2023
Nantong University
2020-2023
University of Shanghai for Science and Technology
2022-2023
Shanghai University of Electric Power
2022
Yan'an University
2008-2022
Shanxi Academy of Medical Sciences
2022
Pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive tumors all over world, has a generally poor prognosis, and its progression is positively correlated with density blood vessels. Recently, tumor-associated macrophages (TAMs) were proven to be beneficial for angiogenesis, but their mechanism action remains unclear. Our study indicated that M2 microvessel (MVD) PDAC tissues, macrophage-derived exosomes (MDEs) could promote angiogenesis mouse aortic endothelial cells (MAECs) in...
Background/Aims: The Snail family of transcription factors controls epithelial to mesenchymal transition (EMT), a process associated with tumorigenesis originated from cells. Snail1 is member and upregulation has been detected in gastric cancer (GC), suggesting potential role GC metastasis. We have recently reported that FBXL5 regulates cortactin by inducing its ubiquitylation subsequent proteasomal degradation, resulting inhibition metastasis GC. However, FBXL4 regulation other...
Therapies designed to target cancer stem cells (CSCs) in colorectal (CRC) may improve treatment outcomes. Different markers have been used identify CSCs or CSC-like CRC, but the enrichment of using these has yet be optimized. We recently reported importance Lgr5-positive CRC growth. Here, we studied possibility Lgr5 and CXCR4 as CSC for CRC. detected high levels stage IV specimens. Both were associated with poor prognosis patients. In vitro, Lgr5+CXCR4-, CXCR4+Lgr5- Lgr5+CXCR4+ purified...
Extranodal extension (ENE) and log odds of positive lymph nodes (LODDS) are associated with the aggressiveness both colon rectal cancers. The current study evaluated clinicopathological significance prognostic impact ENE LODDS in patients independently. clinical histological records 389 colorectal cancer (CRC) who underwent curative surgery were reviewed. For system, 244 ENE1 group 145 ENE2 system. Compared included system prone to nerve invasion (P < 0.001) vessel higher TNM = 0.009), T...
Introduction With the growing need for reliable and precise detection of cell viability in spatial biology, we introduce an antibody-based staining cardiac troponin I (cTnI) as a simple yet valuable tool delineating cardiomyocyte early stages myocardial infarction (MI). Methods &amp; Results In circulation, cTnI was found to be most abundantly released biomarker within first 24 h after MI. heart sections, partial depletion observed dying cardiomyocytes 6 h, with almost absence by despite...
Cortactin, an actin-interacting protein, is implicated in cytoskeletal architecture and often amplified several types of cancer including gastric adenocarcinomas. Downregulation cortactin decreases cell migration invasion. However, how to regulate remains largely unknown. Here, we report that FBXL5 interacts with targets for ubiquitylation subsequent proteasomal degradation. Furthermore, showed FBXL5-induced degradation mediated by extracellular regulated signal kinase (ERK). Serine...
The aim of the present study was to investigate expression forkhead box M1 (FoxM1) and E-cadherin in tissues gastric cancer order reveal any correlation between FoxM1, E‑cadherin clinicopathological parameters. association FoxM1 development progression also investigated. adjacent normal tissue on microarray detected using immunohistochemistry. significance explored, further examined statistical techniques. In tissues, strongly positive, but it weak mucosa. Overexpression evident cancer,...
This study sought to evaluate the prognostic significance of postoperative complications for colon cancer patients undergoing laparoscopic surgery.From May 2006 2009, a total 224 who underwent curative resection (R0) were included in our retrospective study. Postoperative evaluated according standardized grading system. The main outcome measurements overall survival (OS) and relapse-free (RFS), which then compared between no complication groups. Univariate multivariate analysis used assess...
Acute myocardial infarction (AMI) evokes a temporally coordinated immune response, in which monocytes are critically involved the clearance of cell debris; however, excessive inflammation induced by classical sub‑population frequently limits endogenous reparative process. In present study, potential anti‑inflammatory adipokine complement C1q tumor necrosis factor (TNF)‑related protein‑3 (CTRP3) to induce intermediate switch an phenotype was explored. Circulating were isolated from patients...
Learning burnout is students’ passive mental state to the learning. College learning closely related with bad style and culture of society, employment pressure, deficiency college education own factor. Therefore, overcome burnout, teachers must correct deficiencies in teaching, students should also change themselves actively.
The aim of the present study was to investigate expression and functions Forkhead box protein M1 (FoxM1), Caveolin-1 (Cav-1) E-cadherin in colorectal cancer (CRC), determine correlations among these proteins CRC development progression. FoxM1, Cav‑1 E‑cadherin identified using a human normal tissue microarray. A standard immunohistochemistry assay performed employing anti‑FoxM1, anti-Cav-1 anti-E-cadherin antibodies. clinicopathological significance determined, were investigated between...