A5100441786- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- Neurogenesis and neuroplasticity mechanisms
- Epigenetics and DNA Methylation
- Extracellular vesicles in disease
- Nanoplatforms for cancer theranostics
- Ferroptosis and cancer prognosis
- Advanced biosensing and bioanalysis techniques
- Glioma Diagnosis and Treatment
- Bone Metabolism and Diseases
- Plant Genetic and Mutation Studies
- PARP inhibition in cancer therapy
- FOXO transcription factor regulation
- Apelin-related biomedical research
- Carcinogens and Genotoxicity Assessment
- Esophageal Cancer Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Cancer Risks and Factors
- Pregnancy and preeclampsia studies
- Advanced Glycation End Products research
- Cancer Mechanisms and Therapy
East China Jiaotong University
2020-2025
Third Hospital of Hebei Medical University
2025
Hebei Medical University
2025
People 's Hospital of Jilin Province
2025
Hefei First People's Hospital
2025
Anhui Medical University
2025
Beijing Tian Tan Hospital
2012-2024
Capital Medical University
2012-2024
Nanjing Medical University
2011-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2023
Background Colorectal cancer (CRC) remains one of the major types and related death worldwide. Sensitive, non-invasive biomarkers that can facilitate disease detection, staging prediction therapeutic outcome are highly desirable to improve survival rate help determine optimized treatment for CRC. The small non-coding RNAs, microRNAs (miRNAs), have recently been identified as critical regulators various diseases including may represent a novel class biomarkers. purpose this study was identify...
We have evaluated and provided evidence that the ryanodine receptor 3 gene (RYR3), which encodes a large protein forms calcium channel, is important for growth, morphology, migration of breast cancer cells. A putative binding site microRNA-367 (miR-367) exists in 3'UTR RYR3, genetic variant, rs1044129 A→G, present this region. confirmed miR-367 regulates expression reporter driven by RYR3 regulation was affected genotype. thermodynamic model based on base pairing secondary structure mRNA...
Abstract Ovarian carcinoma is the most lethal gynaecological malignancy. Better understanding of molecular pathogenesis this disease and effective targeted therapies are needed to improve patient outcomes. MicroRNAs play important roles in cancer progression have potential for use as either therapeutic agents or targets. Studies other cancers suggested that miR ‐506 has anti‐tumour activity, but its function yet be elucidated. We found deregulation ovarian promotes an aggressive phenotype....
Our aim was to investigate whether microRNAs can predict the clinical outcome of patients with gastric cancer. We used integrated analysis microRNA and mRNA expression profiles identify cancer subtypes their underlying regulatory scenarios.MicroRNA-based were identified by consensus clustering 90 tissues. Activated pathways in gene profiles. Further conducted model a network for each subtype. RNA protein analyzed RT-PCR tissue microarray, respectively, cohort 385 cases (including profiling)...
Sarcopenia, an age-related complication, constitutes a major public health problem given the aging of population. However, it is frequently overlooked and undertreated in mainstream practice. The study aimed to investigate correlations between triglyceride-glucose (TyG) index TyG-body mass (BMI) sarcopenia non-diabetic middle-aged older women whether they would be helpful indicators sarcopenia. This cross-sectional was conducted Department Endocrinology, Hebei Medical University Third...
Abstract Purpose: Esophageal adenocarcinoma is a highly aggressive malignancy that frequently develops from Barrett's esophagus, premalignant pathologic change occurring in the lower end of esophagus. Identifying esophagus patients at high risk malignant transformation essential to prevention esophageal adenocarcinoma. Although microRNA (miRNA) expression signatures have been associated with etiology and prognosis several types cancers, their roles development not extensively evaluated....
Abstract BACKGROUND: More reliable clinical outcome prediction is required to better guide more personalized treatment for patients with primary glioblastoma multiforme (GBM). The objective of this study was identify a microRNA expression signature improve GBM. METHODS: A cohort Chinese GBM (n = 82) analyzed using whole‐genome profiling divided into training set and testing set. Cox regression risk‐score analyses were used develop 5‐microRNA 41 samples. validated in other test samples, an...
Hepatitis B virus (HBV) infection remains a major health problem worldwide. The role played by microRNAs (miRNAs) in HBV replication and pathogenesis is being increasingly recognized. In this study, we found that miR-15b, an important miRNA during hepatocellular carcinoma development, directly binds hepatocyte nuclear factor 1α (HNF1α) mRNA, negative regulator of Enhancer I, to attenuate HNF1α expression, resulting transactivation turn causing the enhancement expression antigens, including...
Notch pathway plays critical role in stem cell maintenance and angiogenesis, as well fate decisions of cancer. However, concrete mechanisms notch regulation glioma were not known, especially mediated by microRNAs. In this study, we identified a brain-specific miRNA, miR-524–5p, which was associated with the pathological grade overall survival gliomas. Restorated expression miR-524–5p suppressed proliferation invasion both vitro vivo . Using bioinformatics biological approaches, found that...
Abstract Emerging evidence has shown the association of aberrantly expressed miR‐106a with cancer development, however, little is known about its potential role in gastric carcinogenesis. In our present study, obviously overexpressed was found tissues compared their nontumor counterparts. Suppression significantly inhibited cell proliferation and triggered apoptosis. Bioinformatic analysis combining validation experiments identified FAS as a direct target miR‐106a. Rescue examination...
The miR-17-92 cluster has long been recognized as an oncogenic microRNA (miRNA) and is amplified in multiple cancers. However, the individual roles of its members carcinogenesis are largely undetermined. After transfection miR‑18a mimics, antisense oligonucleotides inhibitor, siRNAs a luciferase reporter plasmid, MTT assay, colony formation semi-quantitative RT-PCR, assay Western blot analysis were conducted bladder cancer cells. In present study, we showed that miR‑18a, member cluster,...
MicroRNA is a type of endogenous non-coding RNA implicated in various cellular processes, and has been intensely investigated the field cancer research for many years. Here, we functions mechanisms miR-124 prostate cancer, which putative tumor suppressor reported carcinomas.Using bioinformatics, talin 1 was indicated as potential target miR-124. We examined expression levels tissue specimens cell lines. To explore relationship between 1, mimics, inhibitors, small interfering (siRNA) were...
// Wei Yan 1,2,* , Rui Li 2,* Yanwei Liu 1,4,* Pei Yang 1,4 Zheng Wang Chuanbao Zhang Zhaoshi Bao Yongping You 2 and Tao Jiang 1,3,4 1 Beijing Neurosurgical Institute, Capital Medical University, Beijing, PR China Department of Neurosurgery, First Affiliated Hospital Nanjing Nanjing, 3 Institute for Brain Disorders Tumor Center, 4 Tiantan Hospital, * These authors contributed equally to this work Correspondence: Jiang, email: You, Keywords : Anaplastic Gliomas; Secondary Glioblastomas;...
// Ling Xiao 1, 2, 3 , Hui Zhou 4 Xiang-Ping Li 2 Juan Chen Chao Fang Chen-Xue Mao Jia-Jia Cui Wei Zhang Hong-Hao Ji-Ye Yin Zhao-Qian Liu 1 Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Hunan 410078, P.R. China Institute Key Laboratory Pharmacogenetics, Changsha, Histology and Embryology, School Basic Medical Sciences, 410013, The Affiliated Cancer XiangYa Medicine, 410014, Correspondence to: Liu, email: liuzhaoqian63@126.com Yin, yinjiye@csu.edu.cn...
Purpose: MicroRNAs (miRNAs) are key regulators of the growth and development a wide range cancer types such as colorectal (CRC). A number previously studies have observed that levels miR-365a-3p expression dysregulated in many cancers, but specific role this miRNA CRC its association with patient prognosis remains unclear. Methods: The tissues cell lines was detected by Real-time Quantitative polymerase chain reaction (RT-qPCR), while relationship between clinicopathological characteristics...
Alzheimer's disease (AD) is an age-related irreversible neurodegenerative disorder characterized by extracellular β Amyloid(Aβ) deposition, intracellular neurofibrillary tangles and neuronal loss. The dysfunction of neurogenesis increased degeneration neurons contribute to the pathogenesis AD. We now report that miR-211-5p, a small non-coding RNA, can impair neurite differentiation directly targeting NUAK1, decrease viability accelerate progression Aβ-induced pathologies. In this study, we...