A5100753252- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Genetics, Aging, and Longevity in Model Organisms
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Birth, Development, and Health
- RNA Research and Splicing
- Microbial infections and disease research
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Muscle metabolism and nutrition
- Cancer therapeutics and mechanisms
- Cancer-related gene regulation
- BRCA gene mutations in cancer
- Extracellular vesicles in disease
- Lung Cancer Research Studies
- Tannin, Tannase and Anticancer Activities
- Oral and Maxillofacial Pathology
- Dietary Effects on Health
- Urban Transport and Accessibility
Fudan University Shanghai Cancer Center
2018-2025
Shanghai Medical College of Fudan University
2018-2025
Second Xiangya Hospital of Central South University
2017-2024
Huazhong University of Science and Technology
2024
Central Hospital of Wuhan
2024
Central South University
2017-2024
Northwestern University
2024
Southwest Petroleum University
2024
Berry Oncology (China)
2022-2023
Wuhan Polytechnic University
2022-2023
Food restriction has long been known to prolong life in rodents, and recent studies have shown it antiaging effects regard a variety of physiologic pathologic processes. It suggested that these actions food relate the reduction metabolic rate per unit body mass brought about by this dietary regimen. Data are presented report showing can marked life-prolonging action rats without reducing caloric intake gram weight. Moreover, food-restricted consumed greater number calories weight during...
Most modern theories of aging have centered around the notion that age-related deterioration is primarily due to structural and functional modifications cellular constituents. Among them are three currently popular hypotheses — free radical, Glycation, Maillard Theories Aging. The first proposes effects radical reactions damage constituents, while latter propose induced by nonenzymatic gly cation other maillard consequent modification macromolecules as primary cause aging. Although these...
Metabolic rate was determined by measuring O2 consumption in two groups of 6-mo-old male rats fed ad libitum (group 1) or maintained on a life-prolonging food-restriction regimen for 4.5 mo 2). These measurements were made continuously 23.75 h under conditions nearly identical to those the daily life rats. The metabolic per kilogram lean body mass same both groups, finding contrary hypothesis that food restriction retards aging process and prolongs slowing unit mass. This our previous work...
Abstract Human colorectal cancer stem cells (CSCs) are tumour initiating that can self-renew and highly tumorigenic chemoresistant. While genetic mutations associated with human development well-known, little is known about how whether epigenetic factors specifically contribute to the functional properties of CSCs. Here we report KDM3 family histone demethylases plays an important role in potential survival CSCs by epigenetically activating Wnt target gene transcription. The depletion...
Abstract Lithium–sulfur (Li–S) battery is a promising next‐generation energy storage system. However, the poor cyclability caused by shuttle effect still key challenge for its practical application. Here, polypropylene separator modified with α‐MnO 2 /RuO heterostructure presented to facilitate transformation of lithium polysulfides (LiPSs) and optimize rate‐determining step in both reduction oxidation processes sulfur electrode. The unique effectively suppresses dissolution shuttling...
Abstract Cancer‐associated fibroblasts (CAFs) play a crucial role in the progression of pancreatic ductal adenocarcinoma (PDAC). Here, integrated single‐cell RNA sequencing analysis is utilized to comprehensively map CAFs human PDAC tumor microenvironment (TME). Normal (NFs) and nine distinct CAF subtypes are identified including newly subtypes, CDCP1 + FTL CAFs, transitional (tCAFs), interferon simulated genes (ISG) myofibroblastic (myCAFs), proliferative (pCAFs). pCAFs, ISG myCAFs...
Accumulating evidences have demonstrated that long non-coding RNAs (lncRNAs) are involved in the pathophysiology of diabetic nephropathy (DN). lncRNA SOX2OT plays an essential role many diseases, including diabetes. Herein, we aim to investigate underlying mechanism DN pathogenesis. Streptozotocin-induced mouse models and high glucose-induced mesangial cells were constructed examine expression pattern SOX2OT. The activation autophagy was evaluated using immunohistochemistry,...
Long non-coding RNAs (lncRNAs) have proved to act as crucial biomarkers in tumors. Novel non-small cell lung cancer (NSCLC) need be investigated badly. To identify the differentially expressed lncRNAs between NSCLC tissue and adjacent tissue, microarray analysis was performed. lncRNA SLC16A1-AS1 significantly less than that tissue. Gain-of-function experiments performed determine biological functions of SLC16A1-AS. In situhybridization survival were applied samples prognostic role...
Pulp capping, or placing dental materials directly onto the vital pulp tissues of affected teeth, is a procedure that aims to regenerate reparative dentin. Several capping are clinically being used, and calcium ion (Ca 2+ ) released from these known mediate dentin formation. ORAI1 an essential pore subunit store-operated Ca entry (SOCE), which major influx pathway in most nonexcitable cells. Here, we evaluated role mediating odontogenic differentiation mineralization stem cells (DPSCs)....
Hematologic and biochemical data are useful for indicating disease diagnosis growth performance in swine. However, the assessment of these parameters healthy commercial pigs is rare China. Thus, blood samples were collected from 107 nursery 87 sows analyzed 25 hematologic 14 variables. After rejection outliers detection distribution, correlations between hematologic/biochemical RIs preliminarily established using 95% percentile RI. Correlation analysis showed that albumin was hub parameter...
Chemotherapy is one of the common treatment methods for breast cancer, but chemoresistance a severe challenge. Caffeic acid phenethyl ester (CAPE) an active ingredient propolis extract and has been shown to have variety beneficial effects, its potential as cancer worth exploring. The effects CAPE on doxorubicin (DOX) resistance were determined by cell counting kit-8 (CCK-8) assay, colony-formation flow cytometry. Oil Red O staining detection free fatty acids, triglycerides, phospholipids,...
MicroRNAs (miRNAs) are small, non-coding RNAs that key regulators of gene expression by directly binding to the 3'‑untranslated region their target mRNAs, resulting in translational repression or degradation mRNA. It has been demonstrated miRNAs have roles a variety human malignancies, including osteosarcoma. The present study aimed assess molecular mechanism miR‑93 regulation osteosarcoma cell proliferation. Reverse‑transcription quantitative PCR and western blot assays were used examine...
Studies have shown that microRNAs (miRNAs) play a vital role in tumor progression and patients' prognosis. Therefore, we aimed to construct miRNA model for forecasting the survival of hepatocellular carcinoma (HCC) patients. The gene expression data 433 patients with HCC from Cancer Genome Atlas (TCGA) Gene Expression Omnibus public databases were remined by analysis receptor manipulation characteristic curve (ROC). A prognostic including six miRNAs (hsa-mir-26a-1-3p, hsa-mir-188-5p,...
microRNA miR-126 was among the early discovered miRNAs that are expressed specifically in vasculature and have critical functions vascular development. Recent studies started to unveil potentially important function of diseases, including atherosclerosis, coronary artery disease, stroke diabetic vasculopathy. The action reflects its angiogenesis inflammation. expression is downregulated a variety overexpression appears beneficial for most disease models. In minireview, we summarize historic...
Better biomarkers are needed to improve the efficacy of immune checkpoint inhibitors in lung adenocarcinoma (LUAD) treatment. We investigated plasma extracellular vesicle (EV)-derived long RNAs (exLRs) unresectable/advanced LUAD explore for immunochemotherapy. Seventy-four patients without targetable mutations receiving first-line anti-programmed cell death 1 (PD-1) immunochemotherapy were enrolled. Their exLRs profiled through EV transcriptome sequencing. Biomarkers analyzed against...
Abstract The abnormal expression of microRNAs (miRNAs) or protein‐coding genes (PCGs) have been found to be associated with the prognosis hepatocellular carcinoma (HCC) patients. Using bioinformatics analysis methods including Cox’s proportional hazards regression analysis, random survival forest algorithm, Kaplan–Meier, and receiver operating characteristic (ROC) curve we mined gene profiles 469 HCC patients from Cancer Genome Atlas ( n = 379) Gene Expression Omnibus (GSE14520; 90) public...
In an effort to identify human endothelial cell (EC)-enriched lncRNAs,~500 lncRNAs were shown be highly restricted in primary ECs. Among them, lncEGFL7OS, located the opposite strand of EGFL7/miR-126 gene, is regulated by ETS factors through a bidirectional promoter It enriched vascularized tissues, and upregulated hearts dilated cardiomyopathy patients. LncEGFL7OS silencing impairs angiogenesis as EC/fibroblast co-culture, vitro/in vivo ex choroid sprouting assays, while lncEGFL7OS...